INT51461

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 7
Total Number 10
Disease Relevance 5.48
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgb2) plasma membrane (Itgb2)
Anatomy Link Frequency
leukocyte 2
macrophages 1
endothelial cells 1
jejunum 1
developmental stages 1
Itgb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 18 99.64 Very High Very High Very High
Etanercept 12 99.04 Very High Very High Very High
COX2 2 92.16 High High
anesthesia 7 91.56 High High
Chronic pancreatitis 3 89.72 High High
cINOD 6 78.08 Quite High
cytokine 2 75.00 Quite High
Inflammation 22 74.32 Quite High
allodynia 1 72.44 Quite High
Peripheral nerve injury 1 71.28 Quite High
Disease Link Frequency Relevance Heat
Adhesions 25 100.00 Very High Very High Very High
Injury 13 99.56 Very High Very High Very High
Diabetes Mellitus 6 99.38 Very High Very High Very High
INFLAMMATION 27 93.88 High High
Targeted Disruption 4 91.88 High High
Necrosis 2 90.36 High High
Cancer 2 90.00 High High
Pancreatitis 4 89.72 High High
Death 3 88.56 High High
Stress 52 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the expression of CD44, of the integrin component CD18, and of MHC class II was determined.
Spec (determined) Gene_expression (expression) of CD18
1) Confidence 0.75 Published 2002 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 12030436 Disease Relevance 0.33 Pain Relevance 0.29
These results demonstrate that indomethacin-induced leukocyte adherence and mucosal injury are dependent on the expression of CD18 and ICAM-1.
Gene_expression (expression) of CD18 in leukocyte associated with injury
2) Confidence 0.58 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 7694504 Disease Relevance 0.79 Pain Relevance 0.25
High-dose aspirin also reduced the expression of CD11a, CD11b, and CD18, whereas meloxicam and etanercept did not.
Gene_expression (expression) of CD18 associated with aspirin and etanercept
3) Confidence 0.57 Published 2002 Journal FASEB J. Section Abstract Doc Link 11821258 Disease Relevance 1.01 Pain Relevance 0.73
Following one week of diabetes, neutrophil CD11a, CD11b, and CD18 expression was increased significantly, as were retinal ICAM-1 levels.
Gene_expression (expression) of CD18 in neutrophil associated with diabetes mellitus
4) Confidence 0.57 Published 2002 Journal FASEB J. Section Abstract Doc Link 11821258 Disease Relevance 1.12 Pain Relevance 0.44
Minocycline significantly reduced microglial migration to cellular debris, astrocyte-conditioned medium, ADP, and algesic mediators and significantly reduced the expression of CD29 (beta(1)-integrin) but not CD18 (beta(2)-integrin).
Gene_expression (expression) of CD18 in astrocyte
5) Confidence 0.54 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17868321 Disease Relevance 0.44 Pain Relevance 0.20
Expression of adhesion molecules (CD62L, CD49d, CD18), in vitro migration in the Boyden chamber, and infiltrating leukocytes were analyzed by flow cytometry.
Spec (analyzed) Gene_expression (Expression) of CD18 in leukocytes
6) Confidence 0.49 Published 2004 Journal Anesthesiology Section Body Doc Link 14695736 Disease Relevance 0.09 Pain Relevance 0
The developmental stages in females modulate phagocytosis and beta 2-integrin expression in PMNs.
Gene_expression (expression) of beta 2-integrin in developmental stages
7) Confidence 0.40 Published 1996 Journal Inflammation Section Abstract Doc Link 8894713 Disease Relevance 0 Pain Relevance 0.19
Twenty-four hours after the administration of oral antigen a decreased number of cells expressed the CD18 marker in the smooth muscle of the jejunum (Table 2).
Gene_expression (expressed) of CD18 in jejunum
8) Confidence 0.35 Published 2002 Journal BMC Physiol Section Body Doc Link PMC126222 Disease Relevance 0.28 Pain Relevance 0.06
On the other hand, NO reduces MCP-1 expression in macrophages and endothelial cells [19,20] and leads to decreased expressions of cell adhesion molecules such as CD11, CD18, VCAM-1 (vascular cell adhesion molecule-1), and ICAM-1 (intercellular adhesion molecule-1) [21,22], counteracting an adhesion of monocytes to the activated endothelial lining.
Gene_expression (expressions) of CD18 in macrophages associated with adhesions
9) Confidence 0.13 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2949609 Disease Relevance 0.71 Pain Relevance 0.03
On the other hand, NO reduces MCP-1 expression in macrophages and endothelial cells [19,20] and leads to decreased expressions of cell adhesion molecules such as CD11, CD18, VCAM-1 (vascular cell adhesion molecule-1), and ICAM-1 (intercellular adhesion molecule-1) [21,22], counteracting an adhesion of monocytes to the activated endothelial lining.
Gene_expression (expressions) of CD18 in endothelial cells associated with adhesions
10) Confidence 0.05 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2949609 Disease Relevance 0.71 Pain Relevance 0.03

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