INT51468

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Context Info
Confidence 0.48
First Reported 1993
Last Reported 2008
Negated 0
Speculated 3
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 1.50
Pain Relevance 4.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)
Anatomy Link Frequency
medial 2
sensory nerves 1
brain stem 1
Adora2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 144 100.00 Very High Very High Very High
agonist 69 100.00 Very High Very High Very High
Clonidine 10 100.00 Very High Very High Very High
qutenza 7 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
medulla 10 99.20 Very High Very High Very High
antagonist 53 98.76 Very High Very High Very High
Rostral ventrolateral medulla 6 96.64 Very High Very High Very High
Catecholamine 1 89.76 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 3 99.48 Very High Very High Very High
Hypoxia 8 99.08 Very High Very High Very High
Hypertension 1 98.68 Very High Very High Very High
Asthma 1 94.08 High High
Urological Neuroanatomy 2 90.16 High High
Schizophrenia 2 84.48 Quite High
Disease 9 84.44 Quite High
Attention Deficit Hyperactivity Disorder 4 83.72 Quite High
Parkinson's Disease 2 75.00 Quite High
Cognitive Disorder 2 74.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Testosterone treatment, that activates copulatory behaviour in castrates, down regulated alpha2A-AR mRNA levels in the brainstem and 3H-clonidine binding sites densities in the cortex, where terminals of the brain stem neurones are situated.
Regulation (regulated) of alpha2A-AR in brain stem associated with medulla and clonidine
1) Confidence 0.48 Published 2002 Journal Psychoneuroendocrinology Section Abstract Doc Link 11965356 Disease Relevance 0.09 Pain Relevance 0.40
Effects of adenosine A2 receptor agonists on the excitation of capsaicin-sensitive afferent sensory nerves in airway tissues.
Regulation (Effects) of adenosine A2 receptor in sensory nerves associated with adenocard, qutenza and agonist
2) Confidence 0.42 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 7694854 Disease Relevance 0.09 Pain Relevance 1.21
When adenosine concentrations rise, as during anoxia, likely also time appears to be important in regulating A2A receptor activity, which means A2A receptors are “active” under prolonged stimulation [49].
Regulation (regulating) of A2A associated with adenocard and hypoxia
3) Confidence 0.32 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.16 Pain Relevance 0.58
To investigate whether neuroprotection exerted by the A2A antagonist 8-(3-chlorostyryl)caffeine (CSC) correlates with a diminution of the striatopallidal pathway activity, we have examined the changes in the mRNA encoding for enkephalin, dynorphin, and adenosine A2A receptors by in situ hybridization induced by subacute systemic pretreatment with CSC in rats with striatal 6-hydroxydopamine(6-OHDA) administration.
Regulation (changes) of adenosine A2A associated with adenocard, dynorphin, antagonist and enkephalin
4) Confidence 0.32 Published 2005 Journal Exp Brain Res Section Abstract Doc Link 15968457 Disease Relevance 0.31 Pain Relevance 0.50
During postnatal development, alpha-2 adrenergic receptors (A2AR) change in both density and distribution.
Regulation (change) of A2AR
5) Confidence 0.27 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.07
One subtype of imidazoline receptors (IR1) is similar to alpha 2-adrenoceptors (alpha 2 AR) based on their high affinity for clonidine and related imidazoline compounds.
Regulation (affinity) of alpha 2 AR associated with clonidine
6) Confidence 0.17 Published 1997 Journal Life Sci. Section Abstract Doc Link 9364202 Disease Relevance 0 Pain Relevance 0.27
Effect of the A2A agonist CGS 21680 and the A2A antagonist ZM 241385
Regulation (Effect) of A2A associated with antagonist and agonist
7) Confidence 0.17 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC139982 Disease Relevance 0 Pain Relevance 0.34
It is also the main target of alpha2-adrenoceptor (alpha2-AR) agonists used for treatment of hypertension.
Regulation (target) of alpha2-AR associated with hypertension and agonist
8) Confidence 0.15 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10484430 Disease Relevance 0.10 Pain Relevance 0.34
Antisense strategy was used to investigate the role of alpha2A-adrenoceptor (alpha2A-AR) subtype in anxiety-related behavior.
Spec (investigate) Regulation (role) of alpha2A-AR associated with anxiety disorder
9) Confidence 0.09 Published 2002 Journal Psychoneuroendocrinology Section Abstract Doc Link 11965357 Disease Relevance 0.10 Pain Relevance 0.14
In the present study, we recorded field excitatory post-synaptic potential (fEPSP) and evoked excitatory post-synaptic current (eEPSC) in the medial prefrontal cortex (mPFC) of rats, using in vivo field-potential recording and in vitro whole-cell patch-clamp recording techniques, and examined the effects of the alpha2-AR agonist clonidine and the selective alpha2A-AR agonist guanfacine on fEPSP and eEPSC.
Spec (examined) Regulation (effects) of alpha2A-AR in medial associated with agonist and clonidine
10) Confidence 0.09 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17957212 Disease Relevance 0.33 Pain Relevance 0.49
In the present study, we recorded field excitatory post-synaptic potential (fEPSP) and evoked excitatory post-synaptic current (eEPSC) in the medial prefrontal cortex (mPFC) of rats, using in vivo field-potential recording and in vitro whole-cell patch-clamp recording techniques, and examined the effects of the alpha2-AR agonist clonidine and the selective alpha2A-AR agonist guanfacine on fEPSP and eEPSC.
Spec (examined) Regulation (effects) of alpha2A-AR in medial associated with agonist and clonidine
11) Confidence 0.09 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17957212 Disease Relevance 0.33 Pain Relevance 0.49

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