INT51485

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.18
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TAT) mitochondrion (TAT) small molecule metabolic process (TAT)
biosynthetic process (TAT) cellular nitrogen compound metabolic process (TAT) cellular_component (TAT)
Anatomy Link Frequency
T cells 1
TAT (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 93.68 High High
nMDA receptor 2 93.24 High High
excitatory amino acid 4 90.96 High High
tetrodotoxin 2 85.60 High High
Freund adjuvant 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 59 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 6 98.84 Very High Very High Very High
Infection 14 98.68 Very High Very High Very High
Encephalopathy 2 96.32 Very High Very High Very High
Shock 2 95.56 Very High Very High Very High
Apoptosis 1 64.96 Quite High
Viremia 19 5.00 Very Low Very Low Very Low
Immunization 13 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that Tat, released from HIV-1-infected cells, may be an important mediator of neurotoxicity observed in HIV-1 encephalopathy.
Localization (released) of Tat associated with drug induced neurotoxicity, encephalopathy and acquired immune deficiency syndrome or hiv infection
1) Confidence 0.78 Published 1995 Journal Ann. Neurol. Section Abstract Doc Link 7695237 Disease Relevance 0.86 Pain Relevance 0.31
The human immunodeficiency virus type 1 (HIV-1) protein Tat is known to be released from HIV-1-infected cells.
Localization (released) of Tat associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.78 Published 1995 Journal Ann. Neurol. Section Abstract Doc Link 7695237 Disease Relevance 0.50 Pain Relevance 0.25
However, Tat differs from other HIV-1 regulatory proteins because it is rapidly secreted by CD4+ T cells following HIV-1 infection, and extra-cellular Tat is suspected to be directly involved in the collapse of the cellular immune response against HIV-infected cells [2] and directly contributes to the pathology of AIDS [5].
Localization (secreted) of Tat in T cells associated with shock, acquired immune deficiency syndrome or hiv infection and infection
3) Confidence 0.68 Published 2006 Journal Retrovirology Section Body Doc Link PMC1434768 Disease Relevance 0.82 Pain Relevance 0

General Comments

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