INT51540

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Context Info
Confidence 0.47
First Reported 1994
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 1.19
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
caudate nucleus 5
plasma 2
posterior pituitary 2
raphe magnus nucleus 1
spinal cord 1
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 2 100.00 Very High Very High Very High
narcan 2 99.82 Very High Very High Very High
agonist 3 99.80 Very High Very High Very High
Pain 4 99.74 Very High Very High Very High
opiate 2 99.46 Very High Very High Very High
Intracerebroventricular 1 98.58 Very High Very High Very High
Locus ceruleus 4 97.56 Very High Very High Very High
Raphe magnus 4 96.88 Very High Very High Very High
Pain threshold 8 96.00 Very High Very High Very High
Spinal cord 4 95.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 12 99.74 Very High Very High Very High
Opiate Addiction 1 52.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pain stimulation induced oxytocin concentration decrease in the hypothalamic supraoptic nucleus, and increase in the locus coeruleus, raphe magnus nucleus, caudate nucleus and spinal cord, but no change in the hypothalamic paraventricular nucleus and plasma.
Positive_regulation (induced) of Negative_regulation (decrease) of oxytocin in caudate nucleus associated with raphe magnus, pain, locus ceruleus and spinal cord
1) Confidence 0.47 Published 2007 Journal Peptides Section Abstract Doc Link 17420069 Disease Relevance 0.29 Pain Relevance 0.72
Stimulus-induced depletion of pro-enkephalins, oxytocin and vasopressin and pro-enkephalin interaction with posterior pituitary hormone release in vitro.
Positive_regulation (induced) of Negative_regulation (depletion) of oxytocin in posterior pituitary associated with narcan and enkephalin
2) Confidence 0.47 Published 1994 Journal Neuroendocrinology Section Title Doc Link 7700499 Disease Relevance 0.05 Pain Relevance 0.92
Intracerebroventricular (i.c.v.) administration of the kappa-opiate receptor agonist U 69.593 induces a rapid and short lasting suppression of oxytocin (OXT) levels in plasma of water deprived rats, whereas only a tendency towards a suppression of vasopressin (AVP) levels in plasma is observed.
Positive_regulation (induces) of Negative_regulation (suppression) of OXT in plasma associated with agonist, opiate and intracerebroventricular
3) Confidence 0.38 Published 1996 Journal Neuropeptides Section Abstract Doc Link 8923507 Disease Relevance 0 Pain Relevance 0.31
Pain stimulation induced oxytocin concentration decrease in the hypothalamic supraoptic nucleus, and increase in the locus coeruleus, raphe magnus nucleus, caudate nucleus and spinal cord, but no change in the hypothalamic paraventricular nucleus and plasma.
Positive_regulation (induced) of in raphe magnus nucleus Negative_regulation (decrease) of oxytocin in caudate nucleus associated with raphe magnus, pain, locus ceruleus and spinal cord
4) Confidence 0.16 Published 2007 Journal Peptides Section Abstract Doc Link 17420069 Disease Relevance 0.29 Pain Relevance 0.72
Pain stimulation induced oxytocin concentration decrease in the hypothalamic supraoptic nucleus, and increase in the locus coeruleus, raphe magnus nucleus, caudate nucleus and spinal cord, but no change in the hypothalamic paraventricular nucleus and plasma.
Positive_regulation (induced) of in spinal cord Negative_regulation (decrease) of oxytocin in caudate nucleus associated with raphe magnus, pain, locus ceruleus and spinal cord
5) Confidence 0.16 Published 2007 Journal Peptides Section Abstract Doc Link 17420069 Disease Relevance 0.29 Pain Relevance 0.72
Pain stimulation induced oxytocin concentration decrease in the hypothalamic supraoptic nucleus, and increase in the locus coeruleus, raphe magnus nucleus, caudate nucleus and spinal cord, but no change in the hypothalamic paraventricular nucleus and plasma.
Positive_regulation (induced) of in locus coeruleus Negative_regulation (decrease) of oxytocin in caudate nucleus associated with raphe magnus, pain, locus ceruleus and spinal cord
6) Confidence 0.16 Published 2007 Journal Peptides Section Abstract Doc Link 17420069 Disease Relevance 0.29 Pain Relevance 0.72

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