INT51547

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Context Info
Confidence 0.50
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.23
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HCN1) transmembrane transport (HCN1)
Anatomy Link Frequency
HCN-2 1
heart 1
HCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
HCN1 15 100.00 Very High Very High Very High
Potency 4 93.92 High High
Opioid 2 92.56 High High
Nerve growth factor 2 70.08 Quite High
Pain 2 54.32 Quite High
gABA 1 45.60 Quite Low
Glutamate 1 45.12 Quite Low
Somatostatin 1 44.24 Quite Low
Cholecystokinin 1 43.12 Quite Low
Enkephalin 1 40.48 Quite Low
Disease Link Frequency Relevance Heat
Viral Meningitis 2 99.96 Very High Very High Very High
Pain 1 54.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The known HCN blocker ZD7288 was also found to be more selective for HCN1 over HCN4, while the HCN blocker DK-AH269 was equipotent on HCN4 and HCN1.
Positive_regulation (selective) of HCN1 associated with hcn1
1) Confidence 0.50 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18162181 Disease Relevance 0 Pain Relevance 0.47
The known HCN blocker ZD7288 was also found to be more selective for HCN1 over HCN4, while the HCN blocker DK-AH269 was equipotent on HCN4 and HCN1.
Positive_regulation (equipotent) of HCN1 associated with hcn1
2) Confidence 0.50 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18162181 Disease Relevance 0 Pain Relevance 0.48
The depolarizing membrane ionic current I(h) (also known as I(f), "f" for funny), encoded by the hyperpolarization-activated cyclic-nucleotide-modulated (HCN1-4) channel gene family, was first discovered in the heart over 25 years ago.
Positive_regulation (hyperpolarization-activated) of HCN1 in heart associated with hcn1
3) Confidence 0.49 Published 2006 Journal J. Membr. Biol. Section Abstract Doc Link 17558529 Disease Relevance 0.05 Pain Relevance 0.10
Continuous cerebral cortical cell lines have been developed from two patients, an 11-month-old with unilateral megalencephaly and a seven-year-old with Rasmussen's encephalitis, designated HCN-1 and HCN-2, respectively.
Positive_regulation (designated) of HCN-1 in HCN-2 associated with viral meningitis
4) Confidence 0.34 Published 1994 Journal Neuroscience Section Abstract Doc Link 7700510 Disease Relevance 0.17 Pain Relevance 0.07

General Comments

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