INT5156

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Context Info
Confidence 0.27
First Reported 1991
Last Reported 2008
Negated 4
Speculated 0
Reported most in Abstract
Documents 7
Total Number 10
Disease Relevance 2.64
Pain Relevance 5.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (ZC3H12D) nucleus (ZC3H12D) cytoplasm (ZC3H12D)
Anatomy Link Frequency
spinal 1
CPA 1
HPL 1
nerves 1
ZC3H12D (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 140 100.00 Very High Very High Very High
Analgesic 18 99.98 Very High Very High Very High
Antinociceptive 128 99.52 Very High Very High Very High
antagonist 22 99.06 Very High Very High Very High
antinociception 182 98.82 Very High Very High Very High
adenocard 20 98.66 Very High Very High Very High
Pain 22 98.28 Very High Very High Very High
agonist 132 97.92 Very High Very High Very High
withdrawal 6 94.92 High High
anesthesia 1 93.48 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 2 98.70 Very High Very High Very High
Pain 25 98.28 Very High Very High Very High
Middle Cerebral Artery Infarction 6 97.84 Very High Very High Very High
Shock 1 92.64 High High
Nociception 61 89.36 High High
Targeted Disruption 16 87.28 High High
Brain Hemorrhage 2 86.16 High High
Injury 1 74.32 Quite High
Paralysis 36 66.08 Quite High
Death 8 64.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bilateral transection of both the pelvic and hypogastric nerves eliminated the analgesic effects of VS on the TFL and Voc-T tests.
Regulation (effects) of TFL in nerves associated with analgesic
1) Confidence 0.27 Published 1991 Journal Brain Res. Section Abstract Doc Link 1794105 Disease Relevance 0.09 Pain Relevance 0.43
No significant differences were observed between MCAO and sham groups postoperatively, indicating focal ischemic insult induced by this model had no significant influence on TFL.
Neg (no) Regulation (influence) of TFL associated with middle cerebral artery infarction
2) Confidence 0.23 Published 1994 Journal Acta Anaesthesiol. Sin. Section Abstract Doc Link 8038972 Disease Relevance 0.90 Pain Relevance 0.38
The TFL was not affected, HPL was decreased (p < 0.01), and the thresholds of TF and VD were not affected, while, that of VA was significantly decreased.
Neg (not) Regulation (affected) of TFL in HPL
3) Confidence 0.23 Published 2008 Journal Electromagn Biol Med Section Abstract Doc Link 18821202 Disease Relevance 0.77 Pain Relevance 0.64
A low dose (1 mg/kg i.p.) of the dopaminergic agonist apomorphine caused an early mild hyperalgesic response while the high dose (10 mg/kg i.p.) had no significant effect on TFL.
Neg (no) Regulation (effect) of TFL associated with hyperalgesia and agonist
4) Confidence 0.08 Published 2000 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 10791293 Disease Relevance 0.17 Pain Relevance 0.81
The antinociceptive effect of CPA was reversed by classical albeit nonspecific adenosine receptor antagonist theophylline (5 mg/kg) at a dose which had no effect on TFL per se.
Neg (no) Regulation (effect) of TFL in CPA associated with adenocard, antagonist and antinociceptive
5) Confidence 0.08 Published 2000 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 10791293 Disease Relevance 0.17 Pain Relevance 0.83
A logistic curve fit allowed calculation of the ED50 for the spinal action of intrathecal carbachol on TFL (1.4 nmol, coefficient of variation = 5.6%; figure 5).


Regulation (calculation) of TFL in spinal associated with intrathecal
6) Confidence 0.03 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137595 Disease Relevance 0.25 Pain Relevance 0.44
In conclusion this study has shown that cholinergic agonists do produce spinally mediated antinociception affecting both electrical and thermal modalities shown by changes in ECT and TFL.
Regulation (changes) of TFL associated with antinociception and agonist
7) Confidence 0.02 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137595 Disease Relevance 0.15 Pain Relevance 1.03
The resultant line with 95% confidence limits was plotted against dose of drug administered superimposed on a scatter plot of the TFL and ECT responses that were used to calculate the regression lines.


Regulation (responses) of TFL
8) Confidence 0.02 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137595 Disease Relevance 0 Pain Relevance 0.19
Thus each time point after all doses of agonist given in an experiment where the lignocaine test was positive yielded three values, an ECT (n) with the corresponding ECT (t) and TFL values.
Regulation (values) of TFL associated with agonist
9) Confidence 0.02 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137595 Disease Relevance 0 Pain Relevance 0.35
The mean value of TFL was 2.44 +/- 0.11 sec (n = 20).
Regulation (value) of TFL
10) Confidence 0.01 Published 1992 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 1288933 Disease Relevance 0.15 Pain Relevance 0.44

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