INT51561

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Context Info
Confidence 0.09
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.68
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Pigm)
Anatomy Link Frequency
spinal cord 2
nerve 2
neurons 2
Pigm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 9 100.00 Very High Very High Very High
Sciatic nerve 1 95.96 Very High Very High Very High
Root ganglion neuron 1 95.00 High High
inferior alveolar nerve 6 90.80 High High
Trigeminal ganglion neurons 2 89.44 High High
sodium channel 8 86.80 High High
trigeminal ganglion 3 82.44 Quite High
Stimulus evoked pain 4 80.96 Quite High
projection neuron 2 77.04 Quite High
Inflammation 37 75.84 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 3 100.00 Very High Very High Very High
Frailty 7 99.18 Very High Very High Very High
Nervous System Injury 9 96.24 Very High Very High Very High
Ganglion Cysts 9 94.68 High High
Injury 7 85.92 High High
Pain 23 80.96 Quite High
Hypersensitivity 5 80.56 Quite High
Nociception 15 79.64 Quite High
INFLAMMATION 38 75.84 Quite High
Neurodegenerative Disease 1 57.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that expression of PPENK mRNA is more widespread than expression of enkephalin peptides and develops postnatally.
Negative_regulation (develops) of Gene_expression (expression) of PPENK mRNA associated with enkephalin
1) Confidence 0.09 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7700580 Disease Relevance 0.24 Pain Relevance 0.17
RESULTS: After IT administration of SHPZ expression of HPPE mRNA was detected in the spinal cord.
Negative_regulation (administration) of Gene_expression (expression) of HPPE mRNA in spinal cord
2) Confidence 0.03 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 19080437 Disease Relevance 0.16 Pain Relevance 0
We further show that the expression of ankyrin(G) mRNA also is downregulated after nerve lesion and that these changes persist for at least 13 weeks.
Negative_regulation (downregulated) of Gene_expression (expression) of ) mRNA in nerve
3) Confidence 0.02 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10915577 Disease Relevance 1.08 Pain Relevance 0.85
Our results suggest that L-ARG plays an important role in inhibiting KA-induced proENK or proDYN mRNA expression, and its inhibitory action may be mediated through reducing the proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, c-Jun, JunD, and JunB.
Negative_regulation (inhibiting) of Gene_expression (expression) of proDYN mRNA
4) Confidence 0.02 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.07
The link between the ERK activation and proDYN expression was investigated in a study by Woolf et al. in which they used a MEK Inhibitor U0126, which is a chemically synthesized organic compound that inhibits the kinase activity of MAP kinase, to block ERK activation and subsequently found a decrease in the CFA-induced proDYN mRNA expression[17].
Negative_regulation (decrease) of Gene_expression (expression) of proDYN mRNA
5) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978219 Disease Relevance 0.75 Pain Relevance 0.39
where IC50_DR(N) represents the concentration of DR(N) at which the production rate of mRNA is reduced to 50% of its baseline level and ?
Negative_regulation (reduced) of Gene_expression (production) of mRNA
6) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
The IC50_ET1 represents the concentration of TCn at which the production rate of mRNA is reduced to 50% of its baseline level under the inhibition of itself and ?
Negative_regulation (reduced) of Gene_expression (production) of mRNA
7) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
The IC50_DR(N) represents the concentration of DR(N) at which the production rate of mRNA is reduced to 50% of its baseline level under the inhibition of DR(N).
Negative_regulation (reduced) of Gene_expression (production) of mRNA
8) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.09
GDNF selectively prevented: (i) the loss of a subpopulation of striatonigral neurons expressing GAD and PPTA; (ii) the atrophy of PPTA-positive neurons; and (iii) the decrease in GAD, PPTA and DYN mRNA expression, after QUIN injection.
Negative_regulation (decrease) of Gene_expression (expression) of DYN mRNA in neurons associated with generalized anxiety disorder and frailty
9) Confidence 0.01 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 9987028 Disease Relevance 0.44 Pain Relevance 0.04

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