INT51576

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 42
Total Number 43
Disease Relevance 20.12
Pain Relevance 16.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
neutrophil 6
neurons 3
IB4 2
PGE2 2
blood 2
Cxcl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 202 100.00 Very High Very High Very High
chemokine 150 100.00 Very High Very High Very High
ischemia 46 100.00 Very High Very High Very High
Inflammatory mediators 39 100.00 Very High Very High Very High
metalloproteinase 67 99.92 Very High Very High Very High
dorsal root ganglion 103 99.68 Very High Very High Very High
Spinal nerve ligature 10 99.68 Very High Very High Very High
Hyperalgesia 33 99.60 Very High Very High Very High
Pain 136 99.52 Very High Very High Very High
Inflammation 344 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 419 100.00 Very High Very High Very High
Necrosis 26 100.00 Very High Very High Very High
Cancer 25 100.00 Very High Very High Very High
Cv General 4 Under Development 11 100.00 Very High Very High Very High
Urological Neuroanatomy 7 100.00 Very High Very High Very High
Ganglion Cysts 103 99.68 Very High Very High Very High
Hyperalgesia 36 99.60 Very High Very High Very High
Pain 146 99.52 Very High Very High Very High
Adult Respiratory Distress Syndrome 60 99.52 Very High Very High Very High
Disease 11 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The development of intestinal lesions in response to indomethacin was dose-dependently prevented by lansoprazole at a dose of 5 mg/kg together with significant suppression of the increased level of TBARS, MPO activities and CINC-1 in the small bowel.
Positive_regulation (increased) of CINC-1 in bowel associated with urological neuroanatomy
1) Confidence 0.69 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16328016 Disease Relevance 0.63 Pain Relevance 0.25
The hyperalgesia at the site coincided with significant increases in TNF-alpha, IL-1beta, IL-6 and CINC-1 tissue concentrations, peaking 6 h after carrageenan injection (P<0.01, ANOVA).
Positive_regulation (increases) of CINC-1 associated with hyperalgesia
2) Confidence 0.66 Published 2007 Journal Physiol. Behav. Section Abstract Doc Link 17692348 Disease Relevance 0.61 Pain Relevance 0.64
RESULTS: The area (mm2) of macroscopic visible lesions, the concentrations of thiobarbituric acid-reactive substances (TBARS) as an index of lipid peroxidation, myeloperoxidase (MPO) activity as an index of neutrophil accumulation, and the content of cytokine-induced neutrophil chemoattractant-1 (CINC-1) were significantly increased in indomethacin-treated groups compared with the sham groups.
Positive_regulation (increased) of CINC-1 in neutrophil
3) Confidence 0.60 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19148791 Disease Relevance 0.08 Pain Relevance 0
RESULTS: The area (mm2) of macroscopic visible lesions, the concentrations of thiobarbituric acid-reactive substances (TBARS) as an index of lipid peroxidation, myeloperoxidase (MPO) activity as an index of neutrophil accumulation, and the content of cytokine-induced neutrophil chemoattractant-1 (CINC-1) were significantly increased in indomethacin-treated groups compared with the sham groups.
Positive_regulation (increased) of cytokine-induced neutrophil chemoattractant-1 in neutrophil
4) Confidence 0.60 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19148791 Disease Relevance 0.08 Pain Relevance 0
This leads to prolonged mechanical pain behaviors, and a rapid increase in levels of GRO/KC and other pro-inflammatory cytokines [5] in the DRG.
Positive_regulation (increase) of GRO/KC associated with dorsal root ganglion, pain, inflammation and cytokine
5) Confidence 0.60 Published 2009 Journal Mol Pain Section Body Doc Link PMC2698898 Disease Relevance 1.37 Pain Relevance 1.03
The comparison of these two studies suggests that GRO/KC elevations in the localized inflammation model provide one plausible explanation for some, but not all of the changes in ion currents and excitability observed in this model.
Positive_regulation (elevations) of GRO/KC associated with inflammation
6) Confidence 0.60 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0.53 Pain Relevance 0.40
The CINC was induced up to 20 ng/ml from basal 1-2 ng/ml in lipopolysaccharide (LPS)-activated peritoneal macrophages.
Positive_regulation (induced) of CINC in peritoneal macrophages
7) Confidence 0.53 Published 1995 Journal Planta Med. Section Abstract Doc Link 7700986 Disease Relevance 0.23 Pain Relevance 0.21
Thereafter, cytokine concentrations remained elevated for 4 (IL-1beta and IL-6) to 8 days (CINC-1, TNF-alpha) after surgery.
Positive_regulation (elevated) of CINC-1 associated with cytokine
8) Confidence 0.49 Published 2007 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 17823623 Disease Relevance 0.69 Pain Relevance 0.86
Levels of tumor necrosis factor (TNF), interleukin (IL)-1 and IL-6 in the pleural exudate were determined by biological assays, while prostaglandin E2 (PGE2), leukotriene B4 (LTB4) and cytokine-induced chemoattractant-1 (CINC-1) levels were quantified by enzyme immunoassays.
Positive_regulation (cytokine-induced) of CINC-1 in PGE2 associated with necrosis, cancer and cytokine
9) Confidence 0.48 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10361883 Disease Relevance 0.77 Pain Relevance 0.41
Intraplantar injection of CCL2 or CXCL1 produced hyperalgesia to thermal and mechanical stimulation in rats.
Positive_regulation (injection) of CXCL1 associated with hyperalgesia
10) Confidence 0.47 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.77 Pain Relevance 1.13
Expression of each CINC was regulated differently; the production of CINC-1 reached a maximum at 12 h and then slightly decreased after lipopolysaccharide stimulation, whereas that of CINC-2 and CINC-3 increased up to 24 h.
Positive_regulation (increased) of CINC
11) Confidence 0.47 Published 2000 Journal Inflamm. Res. Section Body Doc Link 10738946 Disease Relevance 0.06 Pain Relevance 0
The development of intestinal lesions in response to indomethacin was prevented in Ws/Ws rats compared with W+/W+ rats, together with significant suppression of the increased levels of TBARS, MPO activities, and CINC-1 levels.
Positive_regulation (increased) of CINC-1
12) Confidence 0.46 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19148791 Disease Relevance 0.07 Pain Relevance 0
and CXCR2 ligands (CXCL1/KC in mice or CINC-1 in rats) and they are activated in the site of inflammation by IL-1?
Positive_regulation (activated) of CXCL1 associated with inflammation
13) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.48 Pain Relevance 0.24
The CINC-1 in plasma, muscle, and hind paw was elevated from 3 h to 24 h after carrageenan injection (P < .01).
Positive_regulation (elevated) of CINC-1 in paw
14) Confidence 0.45 Published 2007 Journal J Pain Section Abstract Doc Link 16949880 Disease Relevance 1.20 Pain Relevance 1.04
The finding that GRO/KC enhanced the magnitude of Na+ currents without marked shifts in voltage dependence activation or kinetics (Figure 2, 3), and was observed only after a period of incubation, suggested that the primary effect was an increased number of Na+ channels, and hence that protein synthesis might be required.
Positive_regulation (enhanced) of GRO/KC associated with addiction
15) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.05
Compound 1 also inhibited the hypernociception induced by cytokines (e.g., TNFalpha and CXCL1), but not by inflammatory mediators that directly sensitize the nociceptor such as PGE2 and dopamine.
Neg (not) Positive_regulation (induced) of CXCL1 in nociceptor associated with dopamine, inflammatory mediators, nociceptor and cytokine
16) Confidence 0.43 Published 2009 Journal J. Nat. Prod. Section Abstract Doc Link 19899776 Disease Relevance 0.61 Pain Relevance 0.87
Levels of tumor necrosis factor (TNF), interleukin (IL)-1 and IL-6 in the pleural exudate were determined by biological assays, while prostaglandin E2 (PGE2), leukotriene B4 (LTB4) and cytokine-induced chemoattractant-1 (CINC-1) levels were quantified by enzyme immunoassays.
Positive_regulation (cytokine-induced) of cytokine-induced chemoattractant-1 in PGE2 associated with necrosis, cancer and cytokine
17) Confidence 0.42 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10361883 Disease Relevance 0.77 Pain Relevance 0.41
In this study we found that overnight incubation with GRO/KC (CXCL1), a chemokine that is rapidly upregulated in the DRG in several different models of chronic pain, caused upregulation of K current amplitudes in acutely isolated small diameter IB4-negative DRG neurons in short-term culture.
Positive_regulation (upregulated) of GRO/KC in IB4 associated with dorsal root ganglion, chemokine and lasting pain
18) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2698898 Disease Relevance 0.43 Pain Relevance 0.39
We observed similar large increases of GRO/KC in the spinal nerve ligation model [9].
Positive_regulation (increases) of GRO/KC in spinal nerve associated with spinal nerve ligature
19) Confidence 0.40 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0.90 Pain Relevance 0.90
This caused abnormal spontaneous activity, along with markedly increased sodium currents in small diameter, primarily nociceptive DRG neurons, an overall increase in excitability [7], and a very striking early increase (15-fold after one day) in the chemokine GRO/KC (growth-related oncogene/keratine-derived chemokine; CXCL1) [8].
Positive_regulation (increase) of GRO/KC in neurons associated with nociception and chemokine
20) Confidence 0.40 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0.99 Pain Relevance 0.88

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