INT51577

Context Info Confidence 0.43 First Reported 1995 Last Reported 2009 Negated 1 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.87 Pain Relevance 1.46

extracellular space (Cxcl1) extracellular region (Cxcl1)

Anatomy Link Frequency bowel 2 Cxcl1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat chemokine 1 100.00 cINOD 3 99.44 Hyperalgesia 8 99.14 dexamethasone 1 98.08 antagonist 3 97.88 nociceptor 3 90.88 cytokine 3 90.40 Inflammation 8 82.16 intrathecal 1 82.16

Disease Link Frequency Relevance Heat Urological Neuroanatomy 2 100.00 Cancer 1 100.00 Necrosis 1 100.00 INFLAMMATION 9 99.24 Hyperalgesia 8 99.14 Disease 1 81.12 Enteritis 2 75.00 Injury 1 52.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The development of intestinal lesions in response to indomethacin was dose-dependently prevented by lansoprazole at a dose of 5 mg/kg together with significant suppression of the increased level of TBARS, MPO activities and CINC-1 in the small bowel.

Negative_regulation (suppression) of Positive_regulation (increased) of CINC-1 in bowel associated with urological neuroanatomy

1) Confidence 0.43 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16328016 Disease Relevance 0.64 Pain Relevance 0.25

This CINC induction was significantly inhibited by steroidal anti-inflammatory drugs including dexamethasone, but not by non-steroidal drugs including indomethacin at all.

Negative_regulation (inhibited) of Positive_regulation (induction) of CINC associated with inflammation, cinod and dexamethasone

2) Confidence 0.33 Published 1995 Journal Planta Med. Section Abstract Doc Link 7700986 Disease Relevance 0.26 Pain Relevance 0.23

Co-administration of the selective P2X3,2/3 receptors antagonist A-317491, or the non-selective P2X3 receptor antagonist, TNP-ATP, with carrageenan blocked the mechanical hyperalgesia induced by carrageenan, and significantly reduced the increased concentration of tumor necrosis factor alpha (TNF-alpha) and chemokine-induced chemoattractant-1 (CINC-1) but not of interleukin-1 beta (IL-1 beta) induced by carrageenan.

Negative_regulation (reduced) of Neg (not) Positive_regulation (increased) of CINC-1 associated with chemokine, necrosis, hyperalgesia, cancer and antagonist

3) Confidence 0.17 Published 2009 Journal Pain Section Abstract Doc Link 19081189 Disease Relevance 0.97 Pain Relevance 0.98

General Comments

This test has worked.