INT51577

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.87
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
bowel 2
Cxcl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 1 100.00 Very High Very High Very High
cINOD 3 99.44 Very High Very High Very High
Hyperalgesia 8 99.14 Very High Very High Very High
dexamethasone 1 98.08 Very High Very High Very High
antagonist 3 97.88 Very High Very High Very High
nociceptor 3 90.88 High High
cytokine 3 90.40 High High
Inflammation 8 82.16 Quite High
intrathecal 1 82.16 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 100.00 Very High Very High Very High
Cancer 1 100.00 Very High Very High Very High
Necrosis 1 100.00 Very High Very High Very High
INFLAMMATION 9 99.24 Very High Very High Very High
Hyperalgesia 8 99.14 Very High Very High Very High
Disease 1 81.12 Quite High
Enteritis 2 75.00 Quite High
Injury 1 52.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The development of intestinal lesions in response to indomethacin was dose-dependently prevented by lansoprazole at a dose of 5 mg/kg together with significant suppression of the increased level of TBARS, MPO activities and CINC-1 in the small bowel.
Negative_regulation (suppression) of Positive_regulation (increased) of CINC-1 in bowel associated with urological neuroanatomy
1) Confidence 0.43 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16328016 Disease Relevance 0.64 Pain Relevance 0.25
This CINC induction was significantly inhibited by steroidal anti-inflammatory drugs including dexamethasone, but not by non-steroidal drugs including indomethacin at all.
Negative_regulation (inhibited) of Positive_regulation (induction) of CINC associated with inflammation, cinod and dexamethasone
2) Confidence 0.33 Published 1995 Journal Planta Med. Section Abstract Doc Link 7700986 Disease Relevance 0.26 Pain Relevance 0.23
Co-administration of the selective P2X3,2/3 receptors antagonist A-317491, or the non-selective P2X3 receptor antagonist, TNP-ATP, with carrageenan blocked the mechanical hyperalgesia induced by carrageenan, and significantly reduced the increased concentration of tumor necrosis factor alpha (TNF-alpha) and chemokine-induced chemoattractant-1 (CINC-1) but not of interleukin-1 beta (IL-1 beta) induced by carrageenan.
Negative_regulation (reduced) of Neg (not) Positive_regulation (increased) of CINC-1 associated with chemokine, necrosis, hyperalgesia, cancer and antagonist
3) Confidence 0.17 Published 2009 Journal Pain Section Abstract Doc Link 19081189 Disease Relevance 0.97 Pain Relevance 0.98

General Comments

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