INT51591

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Context Info
Confidence 0.11
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 2.62
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (GLUL) small molecule metabolic process (GLUL) lyase activity (GLUL)
Golgi apparatus (GLUL) intracellular (GLUL) ligase activity (GLUL)
Anatomy Link Frequency
chondrocytes 2
GLUL (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 17 100.00 Very High Very High Very High
gABA 29 99.96 Very High Very High Very High
Osteoarthritis 81 94.52 High High
Enkephalin 2 91.12 High High
cytokine 24 90.84 High High
Inflammation 24 90.56 High High
Opioid 7 90.04 High High
Neurotransmitter 6 79.84 Quite High
agonist 26 70.28 Quite High
Serotonin 8 41.68 Quite Low
Disease Link Frequency Relevance Heat
Glioma 7 98.78 Very High Very High Very High
Spasticity 20 98.40 Very High Very High Very High
Cerebral Palsy 43 98.08 Very High Very High Very High
Stress 27 97.44 Very High Very High Very High
Generalized Anxiety Disorder 17 96.84 Very High Very High Very High
Syndrome 14 96.12 Very High Very High Very High
Ceroid Lipofuscinosis 3 95.76 Very High Very High Very High
Ataxia 5 95.00 High High
Osteoarthritis 81 94.52 High High
Epilepsy 10 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A number of previous reports have described the positive modulation of GS on ER proteins, including GRP78 expression [52], but this is the first time that such modulation was found to arise from GS treatment in chondrocytes; thus interestingly suggesting an specific mechanism of action for the putative anti-inflammatory effect of GS in OA.
Regulation (modulation) of GS in chondrocytes associated with inflammation and osteoarthritis
1) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.62 Pain Relevance 0.27
The aim of this work is to explore the utility of a pharmacoproteomic approach for the identification of specific molecules involved in the pharmacological effect of GS and CS.


Regulation (effect) of GS
2) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945029 Disease Relevance 0.18 Pain Relevance 0.09
To assess the influence of GS and CS on the intracellular pathways of human particularcz chondrocytes, we compared five different conditions: cells before treatment (basal), IL-1?
Regulation (influence) of GS in chondrocytes
3) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0 Pain Relevance 0
Unfortunately, the efficacy of the ligand-induced Gs response was also significantly compromised, diminishing the utility of these receptors.


Regulation (response) of Gs
4) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.07 Pain Relevance 0.04
This effect on phenotypes of glioma C-6 cells was determined using some biochemical parameters: changes in the activity of glutamine synthetase (astrocytic marker) and cyclic nucleotide phosphorohydrolase (oligodendrocytic marker) in the culture of glioma C-6 cells in the early and late passages.
Spec (determined) Regulation (changes) of glutamine synthetase associated with glioma
5) Confidence 0.01 Published 1994 Journal Tsitologiia Section Abstract Doc Link 7701617 Disease Relevance 0.37 Pain Relevance 0.38
Further investigation seems merited of the possibility that variation in the GAD1 sequence, potentially affecting glutamate/GABA ratios, may underlie this form of spastic CP, given the presence of anti-GAD antibodies in SPS and the recognised excitotoxicity of glutamate in various contexts.



Regulation (affecting) of glutamate associated with gaba, glutamate, spasticity, syndrome, generalized anxiety disorder and cerebral palsy
6) Confidence 0.00 Published 2004 Journal BMC Neurol Section Abstract Doc Link PMC544830 Disease Relevance 1.38 Pain Relevance 0.38

General Comments

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