INT516

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 17
Disease Relevance 6.69
Pain Relevance 6.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) cell proliferation (Mif) extracellular space (Mif)
aging (Mif) extracellular region (Mif) nucleus (Mif)
Anatomy Link Frequency
bladder 9
macrophage 2
spinal 1
vas deferens 1
urine 1
Mif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 6 99.96 Very High Very High Very High
Inflammation 295 99.86 Very High Very High Very High
Analgesic 4 99.80 Very High Very High Very High
cytokine 61 99.78 Very High Very High Very High
antagonist 6 99.16 Very High Very High Very High
Enkephalin 2 98.96 Very High Very High Very High
opiate 6 98.72 Very High Very High Very High
Morphine 2 98.12 Very High Very High Very High
tail-flick 2 97.68 Very High Very High Very High
Spinal cord 43 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 319 99.86 Very High Very High Very High
Cystitis 92 99.20 Very High Very High Very High
Ovarian Cancer 21 98.48 Very High Very High Very High
Malignant Neoplastic Disease 6 96.72 Very High Very High Very High
Nociception 2 96.72 Very High Very High Very High
Inflammatory Pain 2 94.76 High High
Asthma 3 93.20 High High
Bacterial Infection 2 92.68 High High
Hyperplasia 8 92.40 High High
Frailty 3 89.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we had shown that a chemical cystitis model (intravesical hydrochloric acid) decreased the overall MIF protein content in the bladder.
Negative_regulation (decreased) of MIF protein in bladder associated with cystitis
1) Confidence 0.59 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.50 Pain Relevance 0.07
We cannot rule out a contribution of renal or ureteral MIF release to increased urine MIF levels observed in this study after CYP-treatment, Yet our current findings of increased urine MIF with concomitant decrease in bladder MIF protein levels are consistent with earlier findings where, in animals with bladders isolated from the kidneys (thus removing potential renal and ureteral contributions), we observed similar results [7], [9]).
Negative_regulation (decrease) of MIF protein in urine
2) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.48 Pain Relevance 0.27
Our previous studies reported the anatomical localization for MIF only in the bladder, while the location of MIF in the peripheral ganglia (MPG; DRG) and in the lumbosacral spinal cord was not determined since the focus was on the change in MIF amounts in these tissues following bladder inflammation [10,11].
Negative_regulation (location) of MIF in bladder associated with inflammation and spinal cord
3) Confidence 0.43 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.51 Pain Relevance 0.42
Unlike naloxone, MIF-I did not seem to reduce food intake in VMH-lesioned rats.
Negative_regulation (reduce) of MIF-I associated with narcan
4) Confidence 0.42 Published 1979 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 43981 Disease Relevance 0 Pain Relevance 0.82
MIF-I was found to block the analgesic effects of enkephalins and also morphine in the tail-flick test but not in the vas deferens assay.
Negative_regulation (block) of MIF-I in vas deferens associated with analgesic, tail-flick, enkephalin and morphine
5) Confidence 0.42 Published 1979 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 43981 Disease Relevance 0 Pain Relevance 0.82
Specifically, spinal administration of a MIF inhibitor (ISO-1) prevented and reversed flinching responses in rats.
Negative_regulation (inhibitor) of MIF in spinal
6) Confidence 0.41 Published 2010 Journal Pain Section Abstract Doc Link 20005040 Disease Relevance 0.59 Pain Relevance 0.59
Thrombin evokes MIF release from rat bladder and upregulates bladder MIF mRNA
Negative_regulation (bladder) of MIF in bladder
7) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0.05
Blocking activation of PAR1 receptors, blocking MIF or receptors for MIF should thus lead to decreased bladder inflammation.


Negative_regulation (blocking) of MIF in bladder associated with inflammation
8) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.24 Pain Relevance 0.34
Blocking activation of PAR1 receptors, blocking MIF or receptors for MIF should thus lead to decreased bladder inflammation.


Negative_regulation (blocking) of MIF in bladder associated with inflammation
9) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.24 Pain Relevance 0.34
Cyclophosphamide treatment caused: 1) significant redistribution of CXCR4 immunostaining to all urothelial layers (especially apical surface of superficial cells) and increased bladder CXCR4 expression; 2) increased urine MIF with decreased bladder MIF; 3) increased bladder SDF-1; 4) increased CXCR4-MIF associations.


Negative_regulation (decreased) of MIF in bladder
10) Confidence 0.36 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2588654 Disease Relevance 0.41 Pain Relevance 0.16
Compared to saline treatment, CYP treatment increased urinary MIF levels (as measured by ELISA; Figure 1E; 22.2±2.8 vs. 57.3±20.5 in saline vs CYP, respectively; p<0.0464) while decreasing bladder MIF levels (Fig 1F; 244.1±39.7 vs 136.0±38.1 ng MIF/mg protein in saline vs CYP treatment respectively; p?
Negative_regulation (decreasing) of MIF in bladder
11) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.47 Pain Relevance 0.12
Therefore, luminal MIF may contribute to bladder inflammation through binding to at least these two urothelial cell-surface receptors and suggests that blocking MIF or cell-surface receptors associated with MIF may prevent or ameliorate bladder inflammation.
Negative_regulation (blocking) of MIF in bladder associated with inflammation
12) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.49 Pain Relevance 0.21
We have demonstrated that released MIF is pro-inflammatory since blocking MIF or receptors for MIF reduce morphological and physiological signs of cystitis as well as decrease bladder production of pro-inflammatory cytokines, including MIF [6], [11], [39].
Negative_regulation (blocking) of MIF in bladder associated with inflammation, cystitis and cytokine
13) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 1.11 Pain Relevance 0.66
We found that one marker, prolactin, was dramatically affected by collection conditions, while CA 125 and MIF were unaffected.
Neg (unaffected) Negative_regulation (unaffected) of MIF
14) Confidence 0.18 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2093996 Disease Relevance 0.31 Pain Relevance 0.09
Composite images showed that PAR1 and MIF immunostaining was limited to basal and occasional intermediate cells (Fig. 2I).
Negative_regulation (limited) of MIF
15) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0
Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.
Negative_regulation (inhibition) of migration inhibitory factor in macrophage associated with cytokine
16) Confidence 0.11 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Title Doc Link 20534506 Disease Relevance 0.44 Pain Relevance 0.30
Inhibition of tautomerization activity of MIF (macrophage migration inhibitory factor), which is shown to be released from ovarian cancer, and which is necessary for proper ovulation; IV.
Negative_regulation (Inhibition) of migration inhibitory factor in macrophage associated with ovarian cancer
17) Confidence 0.06 Published 2004 Journal Neoplasma Section Abstract Doc Link 15254653 Disease Relevance 0.91 Pain Relevance 0.81

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