INT5160

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Context Info
Confidence 0.80
First Reported 1986
Last Reported 2010
Negated 2
Speculated 7
Reported most in Body
Documents 61
Total Number 77
Disease Relevance 42.60
Pain Relevance 19.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (PTAFR) plasma membrane (PTAFR) nucleus (PTAFR)
signal transducer activity (PTAFR)
Anatomy Link Frequency
platelet 14
macrophages 7
neutrophils 7
basophils 4
epithelial cell 3
PTAFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1359 100.00 Very High Very High Very High
cytokine 969 100.00 Very High Very High Very High
substance P 273 99.92 Very High Very High Very High
rheumatoid arthritis 164 99.76 Very High Very High Very High
calcitonin gene related peptide 160 99.64 Very High Very High Very High
bradykinin 87 99.48 Very High Very High Very High
chemokine 286 99.20 Very High Very High Very High
agonist 123 99.12 Very High Very High Very High
Antihistamine 16 99.08 Very High Very High Very High
antagonist 574 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1688 100.00 Very High Very High Very High
Myocardial Infarction 7 99.84 Very High Very High Very High
Rheumatoid Arthritis 176 99.76 Very High Very High Very High
Hypoxia 24 99.68 Very High Very High Very High
Neonatal Necrotizing Enterocolitis 170 99.54 Very High Very High Very High
Congenital Anomalies 22 99.36 Very High Very High Very High
Infection 115 99.32 Very High Very High Very High
Coronary Artery Disease 9 99.24 Very High Very High Very High
Esophageal Disease 220 98.94 Very High Very High Very High
Cv General 3 Under Development 5 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, on the intradermal injection of PAF histamine release and the skin responses, the wheal and the flare, are differentially regulated by neurogenic components.


Localization (release) of PAF histamine in skin
1) Confidence 0.80 Published 1997 Journal J. Allergy Clin. Immunol. Section Body Doc Link 9155831 Disease Relevance 0 Pain Relevance 0
PAF did not release histamine from blood basophils.
Neg (not) Localization (release) of PAF in basophils
2) Confidence 0.80 Published 1997 Journal J. Allergy Clin. Immunol. Section Body Doc Link 9155831 Disease Relevance 0 Pain Relevance 0
However, PAF does not release histamine from human dispersed skin mast cells in vitro.
Neg (not) Localization (release) of PAF in mast cells
3) Confidence 0.80 Published 1997 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 9155831 Disease Relevance 0.10 Pain Relevance 0.05
Platelet-activating factor (PAF) is a phospholipid which is released from a wide range of cell types and also from vascular endothelium.
Localization (released) of Platelet-activating factor in Platelet
4) Confidence 0.80 Published 1996 Journal Clin. Exp. Dermatol. Section Abstract Doc Link 8689766 Disease Relevance 0.81 Pain Relevance 0.57
Platelet-activating factor (PAF) is a phospholipid which is released from a wide range of cell types and also from vascular endothelium.
Localization (released) of PAF in Platelet
5) Confidence 0.80 Published 1996 Journal Clin. Exp. Dermatol. Section Abstract Doc Link 8689766 Disease Relevance 0.80 Pain Relevance 0.54
Clearly, PAF receptor antagonists represent useful therapeutic agents to combat ocular surface disorders where PAF may be released into the tear film.



Localization (released) of PAF in tear associated with antagonist
6) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0.69 Pain Relevance 0.39
PAF-induced cytokine release
Localization (release) of PAF-induced associated with cytokine
7) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0 Pain Relevance 0.09
Platelet activating factor (PAF; 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a potent bioactive phospholipid released from platelets, neutrophils, basophils and macrophages that has been proposed as a mediator of anaphylaxis, acute lung injury and other disorders.
Localization (released) of Platelet activating factor in neutrophils associated with anaphylaxis and adult respiratory distress syndrome
8) Confidence 0.75 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3947392 Disease Relevance 0.19 Pain Relevance 0
Platelet activating factor (PAF; 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a potent bioactive phospholipid released from platelets, neutrophils, basophils and macrophages that has been proposed as a mediator of anaphylaxis, acute lung injury and other disorders.
Localization (released) of PAF in neutrophils associated with anaphylaxis and adult respiratory distress syndrome
9) Confidence 0.75 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3947392 Disease Relevance 0.19 Pain Relevance 0
We hypothesized that PAF, which is released due to hypoxia, infection, or local injury, induces an upregulation of TLR4 at the intestinal epithelium that predisposes to excessive bacterial activation of the intestinal inflammatory response, leading to intestinal necrosis and NEC.
Localization (released) of PAF in intestinal epithelium associated with neonatal necrotizing enterocolitis, necrosis, inflammatory response, hypoxia, injury and infection
10) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 1.31 Pain Relevance 0.17
The purpose of this study was to investigate the extent and possible mechanisms of PAF-induced histamine release in human skin in vivo with the use of dermal microdialysis.
Localization (release) of PAF in skin
11) Confidence 0.71 Published 1997 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 9155831 Disease Relevance 0.09 Pain Relevance 0.05
To determine how platelet-activating factor stimulates colonic anion secretion and increases epithelial permeability, epithelial sheets of rabbit distal colon excluding the submucosal neural plexus were mounted in Ussing chambers.
Localization (secretion) of platelet-activating factor in colon
12) Confidence 0.70 Published 1995 Journal Clin. Sci. Section Abstract Doc Link 7705001 Disease Relevance 0 Pain Relevance 0
Activation of its G protein-coupled receptor, PAF-receptor (PAFR), leads to activation of several signal transduction pathways including the signal transducers and activators of transcription (STATs) and NF?
Localization (receptor) of PAFR
13) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 1.13 Pain Relevance 0.03
In light of PAF's ability to activate NF-?
Localization (ability) of PAF
14) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.32 Pain Relevance 0.12
The aim of the present study was to compare the effects of chemically different NSAIDs (diclofenac, indomethacin, ketoprofen, paracetamol, piroxicam and four fenamates: flufenamic, meclofenamic, mefenamic and tolfenamic acids) on human polymorphonuclear leukocyte (PMN) functions, i.e. calcium ionophore A23187-triggered degranulation, leukotriene B4 (LTB4) release, platelet-activating factor (PAF) production and migration towards LTB4.
Localization (release) of platelet-activating factor in platelet associated with paracetamol, cinod and diclofenac
15) Confidence 0.69 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.16 Pain Relevance 0.56
The aim of the present study was to compare the effects of chemically different NSAIDs (diclofenac, indomethacin, ketoprofen, paracetamol, piroxicam and four fenamates: flufenamic, meclofenamic, mefenamic and tolfenamic acids) on human polymorphonuclear leukocyte (PMN) functions, i.e. calcium ionophore A23187-triggered degranulation, leukotriene B4 (LTB4) release, platelet-activating factor (PAF) production and migration towards LTB4.
Localization (release) of PAF in platelet associated with paracetamol, cinod and diclofenac
16) Confidence 0.69 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.16 Pain Relevance 0.56
The potencies (IC50s) of CV-3988 and PCA-42481 for blocking the PAF-induced cytokine release from HCECs were 4.6–8.6 µM (p<0.05–0.001).


Localization (release) of PAF-induced associated with cytokine
17) Confidence 0.68 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0.08 Pain Relevance 0.18
PAF-induced cytokine synthesis and secretion has the potential to amplify acute inflammatory responses and to lead to the chemosis of neutrophils, basophils, and T-lymphocytes and the potentiation of expression of adhesion molecules, proinflammatory enzymes, and to cause the release of additional cytokines [28-30].
Localization (secretion) of PAF-induced in T-lymphocytes associated with inflammatory response, adhesions and cytokine
18) Confidence 0.68 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0.39 Pain Relevance 0.38
Indeed, in terms of specific ocular effects, PAF has been found in the cornea, iris, ciliary body, and retina and is released into the tear film upon conjunctival provocation [5-7].
Localization (released) of PAF in retina
19) Confidence 0.68 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 1.96 Pain Relevance 0.31
PAF-induced cytokine release
Localization (release) of PAF-induced associated with cytokine
20) Confidence 0.68 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0 Pain Relevance 0.13

General Comments

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