INT51602

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2010
Negated 1
Speculated 6
Reported most in Abstract
Documents 59
Total Number 66
Disease Relevance 17.29
Pain Relevance 26.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm5) cytoplasm (Grm5) signal transducer activity (Grm5)
Anatomy Link Frequency
spinal cord 9
neurons 7
CeA 2
muscle 2
nociceptors 2
Grm5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 565 100.00 Very High Very High Very High
Glutamate receptor 215 100.00 Very High Very High Very High
antagonist 161 100.00 Very High Very High Very High
Spinal cord 71 100.00 Very High Very High Very High
Neuropathic pain 48 100.00 Very High Very High Very High
IPN 2 99.98 Very High Very High Very High
nociceptor 157 99.96 Very High Very High Very High
withdrawal 26 99.84 Very High Very High Very High
Nucleus accumbens 42 99.68 Very High Very High Very High
trigeminal ganglion 34 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 157 100.00 Very High Very High Very High
Inflammatory Pain 2 99.98 Very High Very High Very High
Ganglion Cysts 190 99.50 Very High Very High Very High
Pain 285 99.12 Very High Very High Very High
Arthritis 117 98.98 Very High Very High Very High
INFLAMMATION 47 98.64 Very High Very High Very High
Diabetes Mellitus 16 98.20 Very High Very High Very High
Nociception 125 96.76 Very High Very High Very High
Drug Dependence 8 94.92 High High
Hyperalgesia 43 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of mGluR5 receptors increased over pregnancy.
Gene_expression (Expression) of mGluR5
1) Confidence 0.75 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17304580 Disease Relevance 0.06 Pain Relevance 0.80
Many capsules also contained fine fibers that were labelled by markers associated with nociceptors (calcitonin gene-related peptide, Substance P, P2X3 receptors and TRPV1 receptors) and that expressed the metabotropic glutamate receptor, mGluR5.
Gene_expression (expressed) of mGluR5 in capsules
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link 20559566 Disease Relevance 0 Pain Relevance 0
To confirm group I mGluR expression in cultured neurons, both in situ hybridization and immunocytochemistry were performed, which detected moderate levels of mGluR1 and mGluR5 mRNAs and protein products in most neurons (>70%), respectively.
Gene_expression (levels) of mGluR5 in neurons
3) Confidence 0.75 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11165379 Disease Relevance 0 Pain Relevance 0.25
These findings suggest that increased mGluR5 expression on primary afferent neurons contributes to increased glutamatergic input to spinal dorsal horn neurons and nociceptive transmission in diabetic neuropathic pain.
Gene_expression (expression) of mGluR5 in dorsal horn associated with nociception, diabetes mellitus, neuropathic pain and dorsal horn neuron
4) Confidence 0.75 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 19840219 Disease Relevance 1.14 Pain Relevance 0.58
We previously reported that the levels of metabotropic glutamate 5 (mGlu5) receptor and phosphorylated-protein kinase C (PKC) were significantly increased in the spinal cord following chronic ethanol consumption.
Gene_expression (levels) of mGlu5 in spinal cord associated with kinase c, glutamate and spinal cord
5) Confidence 0.67 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17349994 Disease Relevance 0.39 Pain Relevance 0.62
Vocalizations were recorded in the same animals before arthritis, 6 h after arthritis induction and during administration of antagonists selective for mGluR1 (CPCCOEt) and mGluR5 (MPEP) into the CeA through stereotaxically implanted microdialysis probes.
Gene_expression (selective) of mGluR5 in CeA associated with antagonist, amygdala and arthritis
6) Confidence 0.66 Published 2005 Journal Pain Section Abstract Doc Link 15621382 Disease Relevance 1.04 Pain Relevance 1.17
Vocalizations were recorded in the same animals before arthritis, 6 h after arthritis induction and during administration of antagonists selective for mGluR1 (CPCCOEt) and mGluR5 (MPEP) into the CeA through stereotaxically implanted microdialysis probes.
Gene_expression (selective) of MPEP in CeA associated with antagonist, amygdala and arthritis
7) Confidence 0.65 Published 2005 Journal Pain Section Abstract Doc Link 15621382 Disease Relevance 1.05 Pain Relevance 1.17
These results suggest that NSIA depends on glutamate, released from the central terminals of the primary afferent nociceptors, acting primarily on NMDA and mGluR5 receptors.
Gene_expression (acting) of mGluR5 in nociceptors associated with antinociception, glutamate and nociceptor
8) Confidence 0.65 Published 2003 Journal Pain Section Abstract Doc Link 14581125 Disease Relevance 0 Pain Relevance 1.36
Group I metabotropic glutamate receptors (mGluR1 and mGluR5 subtypes) are positively coupled to phosphoinositide hydrolysis through G-proteins and are densely expressed in medium-sized projection neurons of striatum.
Gene_expression (expressed) of mGluR5 in striatum associated with glutamate receptor and projection neuron
9) Confidence 0.61 Published 2003 Journal Synapse Section Abstract Doc Link 12539198 Disease Relevance 0 Pain Relevance 0.17
The expression of mGluR5 protein increases in the spinal cord of morphine tolerant rats.
Gene_expression (expression) of mGluR5 protein in spinal cord
10) Confidence 0.60 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20058604 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To investigate the expression of metabotropic glutamate receptor 5 (mGluRS) in spinal cord of morphine tolerant rats and understand the influence of mGluR5 antagonist MPEP upon the expression of mGluRS.
Spec (investigate) Gene_expression (expression) of mGluRS in spinal cord associated with antagonist, glutamate receptor, morphine and spinal cord
11) Confidence 0.60 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 20058604 Disease Relevance 0 Pain Relevance 0.40
The expression of mGluR5 in every group was examined by immunofluorescence and Western blot.
Spec (examined) Gene_expression (expression) of mGluR5
12) Confidence 0.60 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20058604 Disease Relevance 0 Pain Relevance 0
The expression of mGluR5 was up-regulated in the dorsal horn of spinal cord in morphine tolerant rats.
Gene_expression (expression) of mGluR5 in spinal cord
13) Confidence 0.60 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20058604 Disease Relevance 0 Pain Relevance 0
At the electron microscopical level, mGluR5a-ir was present exclusively in neuronal somata and dendrites.
Gene_expression (present) of mGluR5a-ir in neuronal
14) Confidence 0.60 Published 1994 Journal Neuroreport Section Abstract Doc Link 7703417 Disease Relevance 0 Pain Relevance 0.31
The present study aimed at determining whether persistent inflammatory pain produces alterations in intracellular and plasma membrane-associated mGluR1alpha and mGluR5 in spinal cord dorsal horn.
Spec (whether) Gene_expression (produces) of mGluR5 in plasma associated with ipn, dorsal horn and spinal cord
15) Confidence 0.60 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17912745 Disease Relevance 0.45 Pain Relevance 0.74
A selective mGluR1 antagonist reduced transmission in CeA neurons from arthritic animals but not in control neurons, and increased levels of mGluR1 and mGluR5 protein were measured in the CeA of arthritic rats compared with controls.
Gene_expression (levels) of mGluR5 protein in neurons associated with antagonist, amygdala and arthritis
16) Confidence 0.59 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12514201 Disease Relevance 0.84 Pain Relevance 1.14
These findings support the idea that the increased levels of mGluR5 in the spinal cord may be, at least in part, involved in the induction of ethanol-dependent neuropathic pain-like state.
Gene_expression (levels) of mGluR5 in spinal cord associated with neuropathic pain and spinal cord
17) Confidence 0.58 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 17081689 Disease Relevance 0.39 Pain Relevance 0.54
OBJECTIVE: To investigate the expression changes of metabotropic glutamate receptor 5 (mGluR5) in neuropathic pain.
Spec (investigate) Gene_expression (expression) of mGluR5 associated with glutamate receptor and neuropathic pain
18) Confidence 0.58 Published 2007 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Abstract Doc Link 17380680 Disease Relevance 0.17 Pain Relevance 0.26
Our results showed that NMDAR1 (NR1), NMDAR2A (NR2A), NMDAR2B (NR2B), AMPAR1 (GluR1) and AMPAR2 (GluR2) subunits, and group I metabotropic glutamate receptor, mGluR5, are constitutively expressed in TG.
Gene_expression (expressed) of mGluR5 associated with glutamate receptor
19) Confidence 0.55 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17560028 Disease Relevance 0.62 Pain Relevance 0.52
MPEP plays its role in morphine tolerance by partly inhibiting the expression of mGluRS.


Gene_expression (expression) of mGluRS
20) Confidence 0.53 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20058604 Disease Relevance 0 Pain Relevance 0

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