INT51603

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Context Info
Confidence 0.73
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.33
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm5) cytoplasm (Grm5) signal transducer activity (Grm5)
Anatomy Link Frequency
neuronal 1
spinal cord dorsal horn 1
synapses 1
Grm5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 54 100.00 Very High Very High Very High
Glutamate receptor 9 100.00 Very High Very High Very High
Spinal cord 21 99.08 Very High Very High Very High
Dorsal horn 12 98.60 Very High Very High Very High
antagonist 16 96.32 Very High Very High Very High
tetrodotoxin 9 95.16 Very High Very High Very High
Dopamine 6 94.58 High High
nMDA receptor 23 89.52 High High
IPN 1 86.00 High High
c fibre 1 85.36 High High
Disease Link Frequency Relevance Heat
Inflammatory Pain 1 86.00 High High
Nociception 16 75.00 Quite High
Hypoxia 144 61.84 Quite High
Depression 4 54.16 Quite High
Ganglion Cysts 13 31.04 Quite Low
Stress 5 6.92 Low Low
Pain 10 5.00 Very Low Very Low Very Low
Decapitation 5 5.00 Very Low Very Low Very Low
Diabetic Retinopathy 4 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We detected an intermittent colocalization of PAM and ubiquitin with TSC2, a known substrate of PAM, and the glutamate receptors mGluR5 and GLUR1.
Localization (colocalization) of mGluR5 associated with glutamate receptor
1) Confidence 0.73 Published 2008 Journal Mol. Cell Proteomics Section Abstract Doc Link 18753128 Disease Relevance 0.16 Pain Relevance 0.22
Immunometal labelling revealed that mGluR5a-ir is concentrated at the periphery of postsynaptic densities of asymmetrical synapses or localized extrasynaptically at dendritic and somatic membranes.
Localization (localized) of mGluR5a-ir in synapses
2) Confidence 0.70 Published 1994 Journal Neuroreport Section Abstract Doc Link 7703417 Disease Relevance 0 Pain Relevance 0.33
Although the synaptic localization of mGluR1 and mGluR5 has been known in the spinal cord dorsal horn [20,21], it has not been clearly demonstrated in the Vo.
Localization (localization) of mGluR5 in spinal cord dorsal horn associated with dorsal horn and spinal cord
3) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0.05 Pain Relevance 0.37
Taken together, these results indicate that mGluR1 and mGluR5 additively contribute to the glutamate release at presynaptic terminals in the Vo, while two subtypes compensate each other for the potentiation of postsynaptic responses.
Localization (release) of mGluR5 associated with glutamate
4) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0 Pain Relevance 0.37
DHPG-induced rise of extracellular dopamine was reversed by tetrodotoxin and by the selective mGlu1 and mGlu5 receptor antagonists 7(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate (CPCCOEt) and 2-methyl-6-(phenylethynyl)pyridine (MPEP) either ICV or into the ventrotegmental area (VTA), suggesting that neuronal release and both mGlu1 and mGlu5 receptors were involved.
Localization (release) of mGlu5 in neuronal associated with tetrodotoxin, dopamine and antagonist
5) Confidence 0.25 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17176263 Disease Relevance 0 Pain Relevance 0.46
We found 22 of these genes were represented on our focused array (GPR51, GRIA3, GRIA4, GRID2, GRIK 1, GRIK3, GRIK4, GRIN1, GRIN2A GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, and GUCY2F).
Localization (array) of GRM5
6) Confidence 0.16 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.11 Pain Relevance 0.13

General Comments

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