INT51607

Context Info Confidence 0.67 First Reported 1994 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 33 Total Number 33 Disease Relevance 32.24 Pain Relevance 3.29

cytosol (DES) cytoskeleton (DES) intracellular (DES) cytoskeleton organization (DES) cytoplasm (DES)

Anatomy Link Frequency smooth muscle 8 muscle 6 neuron 2 PSC 1 globules 1 DES (Homo sapiens)

Pain Link Frequency Relevance Heat substance P 1 100.00 Enkephalin 1 100.00 Inflammatory marker 2 98.44 calcitonin gene related peptide 1 97.60 Inflammation 38 94.08 anesthesia 3 93.20 abdominal pain 8 91.64 cva 12 91.12 alcohol 2 91.12 Angina 8 88.64

Disease Link Frequency Relevance Heat Cancer 457 99.90 Primary Sclerosing Cholangitis 5 99.60 Necrosis 14 99.46 Gastrointestinal Stromal Tumor 108 98.92 INFLAMMATION 36 98.12 Fasciitis 34 97.72 Rhinitis 5 97.72 Carcinoma 83 97.56 Recurrence 48 97.28 Neurilemmoma 35 97.04

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Anatomy

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Muscle biopsy specimens showed myopathic changes, rimmed vacuoles, and accumulation of desmin, dystrophin, and other proteins.

Positive_regulation (accumulation) of desmin in Muscle

1) Confidence 0.67 Published 1999 Journal Ann. Neurol. Section Abstract Doc Link 10970245 Disease Relevance 1.12 Pain Relevance 0.09

Immunohistochemically the tumor stained positive for desmin and sm-actin and negative for CD34 and c-kit.

Positive_regulation (positive) of desmin associated with cancer

2) Confidence 0.49 Published 2006 Journal Dis. Esophagus Section Abstract Doc Link 17069596 Disease Relevance 1.39 Pain Relevance 0.06

Immunohistochemical examination showed proliferating spindle cells, which were positive for vimentin and smooth muscle actin, but negative for desmin, CD34, cytokeratin, epithelial membrane antigen, S100 protein, and neuron specific enolase.

Positive_regulation (negative) of desmin in neuron

3) Confidence 0.49 Published 2007 Journal Surg. Today Section Abstract Doc Link 17243033 Disease Relevance 0.79 Pain Relevance 0.19

Immunohistochemically, the tumor cells showed strong diffuse positivity for HMB-45 while they were negative for c-kit, smooth muscle actin, cytokeratin, S-100, vimentin, desmin, chromogranin, synaptophysin, EMA, and CD-34.

Positive_regulation (negative) of desmin in smooth muscle associated with cancer

4) Confidence 0.49 Published 2007 Journal Tumori Section Abstract Doc Link 17455882 Disease Relevance 0.56 Pain Relevance 0.13

The results showed spindle shaped tumor cells that were strongly positive for c-KIT by CD 117 immunohistochemical staining; other immunohistochemical staining was negative including actin, desmin, S-100 and CD 34 (Figures 2).

Positive_regulation (negative) of desmin associated with cancer

5) Confidence 0.49 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2936326 Disease Relevance 1.31 Pain Relevance 0.10

Immunohistochemical evaluation of the tumour showed a positive immunoreactivity for vimentin, alpha and beta subunits of S-100 protein, neurone-specific enolase (NSE), substance P, met-enkephalin and chromogranin but cytokeratins, desmin, actin, myosin, glial fibrillary acidic protein (GFAP) and calcitonin gene related peptide (CGRP) were negative.

Positive_regulation (immunoreactivity) of desmin associated with calcitonin gene related peptide, cancer, enkephalin and substance p

6) Confidence 0.49 Published 1994 Journal Eur. J. Cancer, B, Oral Oncol. Section Abstract Doc Link 7703807 Disease Relevance 0.76 Pain Relevance 0.20

Histological examination of this mediastinal mass revealed a thymolipoma containing numerous polygonal, striated myoid cells that were immunoreactive for desmin, muscle-specific actin and myoglobin.

Positive_regulation (immunoreactive) of desmin in muscle

7) Confidence 0.49 Published 2007 Journal Tumori Section Abstract Doc Link 17557569 Disease Relevance 0.47 Pain Relevance 0.09

In the present case, the IHC is positive for EMA and desmin, which are smooth muscle markers and CD-68 is an inflammatory marker, suggesting the tumor to be IMT.

Positive_regulation (positive) of desmin in smooth muscle associated with cancer and inflammatory marker

8) Confidence 0.49 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1276822 Disease Relevance 1.69 Pain Relevance 0.17

By immunohistochemical evaluation, the cells were: (a) positive for vimentin and ALK-1 (Fig 5); (b) focally positive for cytokeratins 8/18/19, muscle specific and smooth muscle actins, and desmin; (c) negative for S-100, CD34, c-Kit (CD117), h-caldesmon and MyoD1.

Positive_regulation (negative) of desmin in smooth muscle

9) Confidence 0.49 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2292680 Disease Relevance 0.81 Pain Relevance 0.06

Histological and Immunohistochemical studies in our patients showed a mean maximum diameter of the schwannomas of 12,7 cm (7–20 cm), with areas of degeneration (cases 2, 4 and 5) and atypia (cases 1 and 3), while all were positive for vimentin and S-100 and negative for desmin, smooth muscle actin and HHF35.

Positive_regulation (actin) of desmin in smooth muscle associated with neurilemmoma

10) Confidence 0.49 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2567322 Disease Relevance 1.29 Pain Relevance 0.03

Like the ICC, GISTs have a classic immunohistochemical (IHC) staining pattern (positive for CD34, S-100, DES, keratin, negative for desmin), and, also like the ICC, GIST cells strongly express two kinases, c-kit and platelet-derived growth factor receptor (PDGF-R).

Positive_regulation (negative) of desmin in platelet associated with gastrointestinal stromal tumor

11) Confidence 0.49 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886340 Disease Relevance 0.71 Pain Relevance 0

By immunohistochemistry, all tumors examined were positive for SMA, 1 was positive for desmin, and all were negative for caldesmon and S-100 protein; none showed nuclear staining for beta-catenin.

Positive_regulation (positive) of desmin associated with cancer

12) Confidence 0.49 Published 2006 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 16434899 Disease Relevance 1.23 Pain Relevance 0.13

The tumor cells were immunoreactive for vimentin, desmin, smooth muscle actin, and muscle-specific actin in three of the four cases and were negative for S-100 protein.

Positive_regulation (immunoreactive) of desmin in muscle associated with cancer

13) Confidence 0.49 Published 1999 Journal Mod. Pathol. Section Abstract Doc Link 9950156 Disease Relevance 2.26 Pain Relevance 0.07

Immunohistochemical study results showed that the tumor cells were positive for vimentin, alpha-1-antichymotrypsin (AACT) and desmin staining, and negative for alpha-fetoprotein (AFP), and eosinophilic hyaline globules in the cytoplasm of some giant cells were strongly positive for periodic acid-Schiff (PAS) staining.

Positive_regulation (positive) of desmin in globules associated with rhinitis and cancer

14) Confidence 0.49 Published 2005 Journal World J. Gastroenterol. Section Abstract Doc Link 15682496 Disease Relevance 0.87 Pain Relevance 0.08

In the immunohistochemical study, the tumor was negative for desmin, muscle-specific actin, estrogen, progesterone receptors and CD31, but was positive for vimentin.

Positive_regulation (negative) of desmin in muscle associated with cancer

15) Confidence 0.49 Published 2002 Journal Eur. J. Gynaecol. Oncol. Section Abstract Doc Link 12214741 Disease Relevance 0.59 Pain Relevance 0.12

Immunohistochemistry showed the spindle cells to be immunoreactive for vimentin, smooth muscle actin and muscle specific actin and, focally, for desmin; immunostaining for cytokeratin, epithelial membrane antigen, S-100 protein, factor VIII-related antigen, and CD34 was negative.

Positive_regulation (immunoreactive) of desmin in muscle

16) Confidence 0.49 Published 1997 Journal Tumori Section Abstract Doc Link 9428923 Disease Relevance 0.45 Pain Relevance 0.09

The tumor cells were all immunoreactive for vimentin, CD 34, and focally actin-positive in one case, but not for keratin, desmin, S-100 protein, carcinoembryonic antigen, alpha 1-ACT and F VIII-related antigen, supported a primitive mesenchymal origin. p53 protein was expressed in two of the malignant cases.

Positive_regulation (immunoreactive) of desmin associated with malignant neoplastic disease and cancer

17) Confidence 0.49 Published 1999 Journal Lung Cancer Section Abstract Doc Link 10100146 Disease Relevance 2.34 Pain Relevance 0.12

The glandular epithelium was decorated with antibodies to pan-cytokeratin, CK7, BER-EP4, ER, and PR, whereas the stromal cells showed positive staining for vimentin, actin, smooth muscle actin, desmin, ER, and PR.

Positive_regulation (staining) of desmin in epithelium

18) Confidence 0.49 Published 1998 Journal Hum. Pathol. Section Abstract Doc Link 9865838 Disease Relevance 0.54 Pain Relevance 0.20

The cells were focally positive for the muscle markers including h-caldesmon, desmin, actin and myoglobin.

Positive_regulation (positive) of desmin in muscle

19) Confidence 0.45 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2409332 Disease Relevance 0.79 Pain Relevance 0.03

Some cells were positive for desmin and myogenin (figure 2b, 2c).

Positive_regulation (positive) of desmin

20) Confidence 0.45 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1361803 Disease Relevance 0.70 Pain Relevance 0

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