INT51625

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Context Info
Confidence 0.60
First Reported 1994
Last Reported 2010
Negated 5
Speculated 5
Reported most in Abstract
Documents 12
Total Number 17
Disease Relevance 3.28
Pain Relevance 11.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
brain 8
spinal cord 4
CeA 3
cerebellar granule cells 2
spinal cord dorsal horn 2
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 198 100.00 Very High Very High Very High
Glutamate 74 100.00 Very High Very High Very High
Morphine 22 100.00 Very High Very High Very High
substance P 14 100.00 Very High Very High Very High
Glutamate receptor 12 100.00 Very High Very High Very High
Intracerebroventricular 6 100.00 Very High Very High Very High
butorphanol 9 99.84 Very High Very High Very High
Spinal cord 44 99.68 Very High Very High Very High
Nucleus accumbens 17 99.40 Very High Very High Very High
nMDA receptor antagonist 19 99.06 Very High Very High Very High
Disease Link Frequency Relevance Heat
Brain Hemorrhage 38 98.24 Very High Very High Very High
Injury 27 98.12 Very High Very High Very High
Pain 17 94.32 High High
Urological Neuroanatomy 3 93.84 High High
Stress 3 93.80 High High
Hyperalgesia 15 93.00 High High
INFLAMMATION 35 89.56 High High
Brain Injury 2 88.72 High High
Drug Dependence 3 87.64 High High
Neuropathic Pain 21 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activity-dependent regulation of N-methyl-D-aspartate receptor subunit expression in rat cerebellar granule cells.
Regulation (regulation) of Gene_expression (expression) of N-methyl-D-aspartate receptor subunit in cerebellar granule cells associated with nmda receptor
1) Confidence 0.60 Published 1994 Journal Eur. J. Neurosci. Section Title Doc Link 7704293 Disease Relevance 0 Pain Relevance 0.22
These results provide evidence that the expression of the NR2A and B subunits is regulated through an activity-dependent mechanism leading to the formation of NMDA receptors with different pharmacological properties.
Regulation (regulated) of Gene_expression (expression) of NR2A associated with nmda receptor
2) Confidence 0.60 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7704293 Disease Relevance 0 Pain Relevance 0.29
We have used rat cerebellar slice cultures to test the involvement of bioelectrical activity and synaptic transmission in the changes in NR2A-C expression observed in developing granule cells.
Regulation (changes) of Gene_expression (expression) of NR2A in granule cells
3) Confidence 0.60 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7704293 Disease Relevance 0 Pain Relevance 0.16
In this study we examined the effects of chronic morphine administration on gene and protein expression of three major NMDA receptors subunits (NR1, NR2A, and NR2B) in NAcc and CeA.
Spec (examined) Regulation (effects) of Gene_expression (expression) of NR2A in CeA associated with nucleus accumbens, nmda receptor, amygdala and morphine
4) Confidence 0.47 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16453311 Disease Relevance 0.09 Pain Relevance 1.50
Under these conditions, mRNA and protein levels of NR1, NR2A and NR2B subunits did not change in the spinal cord of chronic ethanol-fed rats.
Neg (not) Regulation (change) of Gene_expression (levels) of NR2A in spinal cord associated with spinal cord
5) Confidence 0.42 Published 2007 Journal Life Sci. Section Abstract Doc Link 17156796 Disease Relevance 0.49 Pain Relevance 0.79
We have examined the effect of intracerebroventricular injections of SP(1-7) on the expression of the NMDA receptor subunits NR1, NR2A and NR2B mRNAs in the spinal cord and in discrete areas of the male rat brain.
Spec (examined) Regulation (effect) of Gene_expression (expression) of NR2A in brain associated with nmda receptor, intracerebroventricular, spinal cord and substance p
6) Confidence 0.41 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10978586 Disease Relevance 0.26 Pain Relevance 1.04
Intracerebroventricular injection of the N-terminal substance P fragment SP(1-7) regulates the expression of the N-methyl-D-aspartate receptor NR1, NR2A and NR2B subunit mRNAs in the rat brain.
Regulation (regulates) of Gene_expression (expression) of NR2A in brain associated with nmda receptor, intracerebroventricular and substance p
7) Confidence 0.41 Published 2000 Journal Neurosci. Lett. Section Title Doc Link 10978586 Disease Relevance 0.26 Pain Relevance 1.04
Altered expression of NR2A and NR2B, which depends on the duration of focal cerebral ischemia, could play variable roles in secondary brain cell injury in the penumbra
Regulation (Altered) of Gene_expression (expression) of NR2A in brain associated with brain hemorrhage, ischemia and injury
8) Confidence 0.41 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.45 Pain Relevance 0.25
Western blot and immunohistochemistry were performed to determine changes in Sig-1R expression and to examine the effect of BD1047 on N-methyl-D-aspartate receptor subunit 1 expression and phosphorylation in spinal cord dorsal horn from neuropathic rats.
Spec (examine) Regulation (effect) of Gene_expression (expression) of N-methyl-D-aspartate receptor subunit 1 in spinal cord dorsal horn
9) Confidence 0.37 Published 2008 Journal Anesthesiology Section Body Doc Link 18946301 Disease Relevance 0.16 Pain Relevance 0
Regarding the NR2 subunit expression in controls, NR2B exhibited the highest expression, followed by decreasing proportions of NR2C, NR2A, and NR2D.
Regulation (controls) of Gene_expression (expression) of NR2
10) Confidence 0.35 Published 2002 Journal Amino Acids Section Abstract Doc Link 12373534 Disease Relevance 0.09 Pain Relevance 0.41
However, no change in the levels of NR1, NR2A, and NR2B subunits was observed in slices treated with 1 µM UCB for 24 h.
Neg (no) Regulation (change) of Gene_expression (levels) of NR2A
11) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0 Pain Relevance 0.36
Simultaneous treatment of slices with UCB (10 µM) and the NMDA receptor antagonist D-APV (50 µM) for 48 h induced no significant changes in the levels of NR1, NR2A, and NR2B subunits (Figure 8A–D).
Neg (no) Regulation (changes) of Gene_expression (levels) of NR2A associated with nmda receptor antagonist
12) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.45 Pain Relevance 0.51
The effects of continuous infusion of butorphanol on the modulation of NMDA receptor subunit NR1, NR2A, NR2B, and NR2C gene expression were investigated by using in situ hybridization technique.
Regulation (modulation) of Gene_expression (expression) of NR2A associated with nmda receptor and butorphanol
13) Confidence 0.25 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11152389 Disease Relevance 0 Pain Relevance 1.00
In addition, these investigators reported no change in the expression of NR2 protein in the spinal cord following the CFA treatment.
Neg (no) Spec (investigators) Regulation (change) of Gene_expression (expression) of NR2 protein in spinal cord associated with spinal cord
14) Confidence 0.23 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.64 Pain Relevance 0.80
Expression of ionotropic glutamate receptor subunits NR2A, NR2B and GluR2, and of the vesicular glutamate transporter VGLUT1 was also previously shown not to be altered by CNTF [12].
Regulation (altered) of Gene_expression (Expression) of NR2A associated with glutamate and glutamate receptor
15) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0.13 Pain Relevance 0.53
In this study we examined the effects of chronic morphine administration on gene and protein expression of three major NMDA receptors subunits (NR1, NR2A, and NR2B) in NAcc and CeA.
Spec (examined) Regulation (effects) of in NAcc Gene_expression (expression) of NR2A in CeA associated with nucleus accumbens, nmda receptor, amygdala and morphine
16) Confidence 0.16 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16453311 Disease Relevance 0.09 Pain Relevance 1.50
The expression of NR2A and NR2B subunit mRNAs did not change after morphine treatment in any brain region.
Neg (not) Regulation (change) of Gene_expression (expression) of NR2A in brain associated with morphine
17) Confidence 0.09 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9988122 Disease Relevance 0.17 Pain Relevance 1.19

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