INT51626

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Context Info
Confidence 0.68
First Reported 1994
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 1.65
Pain Relevance 10.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
brain 2
striatum 2
spinal cord 1
caudate putamen 1
forebrain 1
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 99 100.00 Very High Very High Very High
Dopamine 17 100.00 Very High Very High Very High
substance P 8 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
Neuropeptide 4 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
Morphine 50 99.92 Very High Very High Very High
antagonist 24 99.12 Very High Very High Very High
Somatostatin 6 98.92 Very High Very High Very High
Central grey 2 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Schizophrenia 12 98.88 Very High Very High Very High
Drug Dependence 10 96.36 Very High Very High Very High
Pain 16 94.32 High High
Urological Neuroanatomy 5 93.84 High High
Stress 1 93.80 High High
Hyperalgesia 15 93.00 High High
Cognitive Disorder 14 92.76 High High
Neuropathic Pain 18 84.72 Quite High
Non-diabetic Peripheral Neuropathy 1 72.28 Quite High
Anxiety Disorder 47 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the genetic section, the mRNA expression of NMDA receptor subunits (NR1 and NR2A) was measured in certain areas of the male rat brain (striatum, prefrontal cortex, hippocampus, hypothalamus and amygdala).
Transcription (expression) of NR2A in prefrontal associated with nmda receptor, hippocampus and amygdala
1) Confidence 0.68 Published 2008 Journal Pharmacology Section Abstract Doc Link 18391508 Disease Relevance 0 Pain Relevance 0.64
In order to investigate whether early VH lesion in rats alters the expression of genes implicated in schizophrenia pre- and post-puberty, we studied the mRNA expression of neuropeptides (substance P, dynorphin and enkephalin), dopamine D1, dopamine D2, and NMDA (subunits NR1 and NR2A) receptors in this animal model.
Transcription (expression) of NR2A associated with dopamine, dynorphin, neuropeptide, enkephalin, hippocampus, schizophrenia and substance p
2) Confidence 0.67 Published 2009 Journal Schizophr. Res. Section Abstract Doc Link 19500946 Disease Relevance 0.27 Pain Relevance 0.64
Under these conditions, mRNA and protein levels of NR1, NR2A and NR2B subunits did not change in the spinal cord of chronic ethanol-fed rats.
Transcription (levels) of NR2A in spinal cord associated with spinal cord
3) Confidence 0.66 Published 2007 Journal Life Sci. Section Abstract Doc Link 17156796 Disease Relevance 0.49 Pain Relevance 0.78
The acute effects of subcutaneously injected morphine on transcripts of the NMDA receptor subunits NR1, NR2A and NR2B in certain areas of the central nervous system of male rats were examined by Northern blot analysis.
Transcription (transcripts) of NR2A in central nervous system associated with nmda receptor, central nervous system and morphine
4) Confidence 0.66 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543234 Disease Relevance 0 Pain Relevance 0.61
Bath application of the NR2A relatively selective antagonist NVP-AAM077 (0.3 ?
Transcription (application) of NR2A associated with antagonist
5) Confidence 0.57 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0 Pain Relevance 0.51
Cellular distribution of the NMDA receptor NR2A/2B subunits in the rat striatum.
Transcription (distribution) of NR2A in striatum associated with nmda receptor and enkephalin
6) Confidence 0.54 Published 1996 Journal Brain Res. Section Title Doc Link 9017267 Disease Relevance 0 Pain Relevance 0.45
Granule cells grown under standard culture conditions expressed mainly NR2A mRNA when examined after 15-40 days in vitro.
Transcription (expressed) of NR2A in Granule cells
7) Confidence 0.52 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7704293 Disease Relevance 0 Pain Relevance 0.24
To analyze NR1 and NR2 protein a sample of the denaturing buffer containing 20 ?
Spec (analyze) Transcription (analyze) of NR2 protein
8) Confidence 0.52 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0 Pain Relevance 0
Continuous intracerebroventricular (i.c.v.) infusion with butorphanol (26 nmol/microl/h) resulted in significant modulations in the NRI, NR2A, and NR2B mRNA levels.
Transcription (levels) of NR2A associated with butorphanol and intracerebroventricular
9) Confidence 0.50 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11152389 Disease Relevance 0 Pain Relevance 1.31
Intracerebroventricular injection of the N-terminal substance P fragment SP(1-7) regulates the expression of the N-methyl-D-aspartate receptor NR1, NR2A and NR2B subunit mRNAs in the rat brain.
Transcription (expression) of NR2A in brain associated with nmda receptor, intracerebroventricular and substance p
10) Confidence 0.48 Published 2000 Journal Neurosci. Lett. Section Title Doc Link 10978586 Disease Relevance 0.26 Pain Relevance 1.04
In this study, we determined whether prenatal morphine exposure altered the synaptic complex association between PSD-95 and three major NMDAR subunits (NR1, NR2A, and NR2B), at the mRNA and protein levels, within the hippocampal CA1 subregion (an important integration area for mammalian learning and memory) of rat offspring along with the performance of long-term cognitive functions.
Transcription (mRNA) of NR2A associated with cognitive disorder and morphine
11) Confidence 0.43 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.17 Pain Relevance 0.51
NMDAR2A mRNA was present at moderate levels in all striatal neurons except those containing ChAT.
Transcription (present) of NMDAR2A in neurons
12) Confidence 0.42 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9889300 Disease Relevance 0 Pain Relevance 0.38
MDMA increased mRNA expression levels of glutamatergic NMDA receptor subunits NR1, NR2A and NR2B in the forebrain cortex, NR2A and 2B in the CPU, and NR1 and NR2A (lower dose) in the hypothalamus.
Transcription (levels) of NR2A in forebrain associated with nmda receptor
13) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0.29
In the caudate putamen, mRNA levels of GluR3, NR2A, and NR2B receptor subunits were significantly increased.
Transcription (levels) of NR2A in caudate putamen
14) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2358913 Disease Relevance 0.13 Pain Relevance 0.38
In the genetic section, the mRNA expression of NMDA receptor subunits (NR1 and NR2A) was measured in certain areas of the male rat brain (striatum, prefrontal cortex, hippocampus, hypothalamus and amygdala).
Transcription (expression) of NR2A in striatum associated with nmda receptor, hippocampus and amygdala
15) Confidence 0.23 Published 2008 Journal Pharmacology Section Abstract Doc Link 18391508 Disease Relevance 0 Pain Relevance 0.64
The expression of NR2A and NR2B subunit mRNAs did not change after morphine treatment in any brain region.
Transcription (expression) of NR2A in brain associated with morphine
16) Confidence 0.11 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9988122 Disease Relevance 0.17 Pain Relevance 1.18
Using in situ hybridization techniques, the effects of chronic morphine treatment on the expression of mRNAs encoding the NMDA receptor subunits NRI, NR2A, and NR2B were investigated.
Transcription (expression) of NR2A associated with nmda receptor and morphine
17) Confidence 0.11 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9988122 Disease Relevance 0.17 Pain Relevance 0.91

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