INT51627

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Context Info
Confidence 0.76
First Reported 1994
Last Reported 2010
Negated 2
Speculated 4
Reported most in Abstract
Documents 82
Total Number 90
Disease Relevance 25.09
Pain Relevance 47.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
brain 8
NAcc 4
spinal cord 3
granule cells 3
neuron 3
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 1201 100.00 Very High Very High Very High
Glutamate 400 100.00 Very High Very High Very High
antagonist 190 100.00 Very High Very High Very High
Nucleus accumbens 93 100.00 Very High Very High Very High
Glutamate receptor 74 100.00 Very High Very High Very High
Kinase C 32 100.00 Very High Very High Very High
Inflammation 271 99.92 Very High Very High Very High
long-term potentiation 934 99.84 Very High Very High Very High
butorphanol 27 99.84 Very High Very High Very High
ischemia 366 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 17 100.00 Very High Very High Very High
INFLAMMATION 265 99.92 Very High Very High Very High
Brain Hemorrhage 232 99.76 Very High Very High Very High
Teratocarcinoma 2 99.56 Very High Very High Very High
Neuropathic Pain 114 99.44 Very High Very High Very High
Nociception 171 99.40 Very High Very High Very High
Hyperalgesia 84 98.92 Very High Very High Very High
Anxiety Disorder 259 98.68 Very High Very High Very High
Morphine Dependence 2 98.28 Very High Very High Very High
Injury 201 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activity-dependent regulation of N-methyl-D-aspartate receptor subunit expression in rat cerebellar granule cells.
Gene_expression (expression) of N-methyl-D-aspartate receptor subunit in cerebellar granule cells associated with nmda receptor
1) Confidence 0.76 Published 1994 Journal Eur. J. Neurosci. Section Title Doc Link 7704293 Disease Relevance 0 Pain Relevance 0.22
These results provide evidence that the expression of the NR2A and B subunits is regulated through an activity-dependent mechanism leading to the formation of NMDA receptors with different pharmacological properties.
Gene_expression (expression) of NR2A associated with nmda receptor
2) Confidence 0.76 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7704293 Disease Relevance 0 Pain Relevance 0.29
We have used rat cerebellar slice cultures to test the involvement of bioelectrical activity and synaptic transmission in the changes in NR2A-C expression observed in developing granule cells.
Gene_expression (expression) of NR2A in granule cells
3) Confidence 0.76 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7704293 Disease Relevance 0 Pain Relevance 0.16
Transient expression of the rat NR1a/NR2A complex in human embryonic kidney 293 cells confirmed a coexpression of (125)I-(des-tyrosyl) dynorphin A(2-17), [(3)H]CGP39,653, and [(3)H]MK-801 binding.
Gene_expression (expression) of NR2A in embryonic kidney associated with dynorphin
4) Confidence 0.75 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10525097 Disease Relevance 0 Pain Relevance 0.61
We also report a reduced expression of NR2A following peripheral nerve lesion.
Gene_expression (expression) of NR2A in peripheral nerve
5) Confidence 0.74 Published 2002 Journal Neuroscience Section Abstract Doc Link 12088745 Disease Relevance 0.16 Pain Relevance 0.68
Following nerve lesion, fewer neurones expressed NR2A compared to the control.
Gene_expression (expressed) of NR2A in nerve
6) Confidence 0.74 Published 2002 Journal Neuroscience Section Abstract Doc Link 12088745 Disease Relevance 0.29 Pain Relevance 0.79
The effects of continuous infusion of butorphanol on the modulation of NMDA receptor subunit NR1, NR2A, NR2B, and NR2C gene expression were investigated by using in situ hybridization technique.
Gene_expression (expression) of NR2A associated with nmda receptor and butorphanol
7) Confidence 0.73 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11152389 Disease Relevance 0 Pain Relevance 1.00
Under these conditions, mRNA and protein levels of NR1, NR2A and NR2B subunits did not change in the spinal cord of chronic ethanol-fed rats.
Gene_expression (levels) of NR2A in spinal cord associated with spinal cord
8) Confidence 0.72 Published 2007 Journal Life Sci. Section Abstract Doc Link 17156796 Disease Relevance 0.49 Pain Relevance 0.78
Our results showed that NMDAR1 (NR1), NMDAR2A (NR2A), NMDAR2B (NR2B), AMPAR1 (GluR1) and AMPAR2 (GluR2) subunits, and group I metabotropic glutamate receptor, mGluR5, are constitutively expressed in TG.
Gene_expression (xpressed ) of NR2A associated with glutamate receptor
9) Confidence 0.72 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17560028 Disease Relevance 0.62 Pain Relevance 0.53
Our results showed that NMDAR1 (NR1), NMDAR2A (NR2A), NMDAR2B (NR2B), AMPAR1 (GluR1) and AMPAR2 (GluR2) subunits, and group I metabotropic glutamate receptor, mGluR5, are constitutively expressed in TG.
Gene_expression (xpressed ) of NMDAR2A associated with glutamate receptor
10) Confidence 0.72 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17560028 Disease Relevance 0.62 Pain Relevance 0.53
Western blot analysis indicated that the protein translation products of the NR2A subunit were also increased (P < 0.01).
Gene_expression (products) of NR2A subunit
11) Confidence 0.71 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11826044 Disease Relevance 0.85 Pain Relevance 0.93
We have examined the effect of intracerebroventricular injections of SP(1-7) on the expression of the NMDA receptor subunits NR1, NR2A and NR2B mRNAs in the spinal cord and in discrete areas of the male rat brain.
Gene_expression (expression) of NR2A in brain associated with nmda receptor, intracerebroventricular, spinal cord and substance p
12) Confidence 0.70 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10978586 Disease Relevance 0.26 Pain Relevance 1.03
We further investigated the expression of NR1 splice variants, NR2A and NR2B protein.
Spec (investigated) Gene_expression (expression) of NR2A
13) Confidence 0.67 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.64 Pain Relevance 0.22
Previous studies have shown that in the neonatal brain, NMDA receptors are composed nearly all by NR2B subunits and that the expression of NR2A starts at 6–10 days postnatal age.
Gene_expression (expression) of NR2A in brain associated with nmda receptor
14) Confidence 0.66 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.20 Pain Relevance 0.30
A correlation between the functional properties of the NMDA receptors and expression of the NR2A-C mRNAs was obtained in single granule cells by coupling patch-clamp recording and reverse transcription followed by polymerase chain reaction.
Gene_expression (expression) of NR2A in granule cells associated with nmda receptor
15) Confidence 0.66 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7704293 Disease Relevance 0 Pain Relevance 0.22
Granule cells grown under standard culture conditions expressed mainly NR2A mRNA when examined after 15-40 days in vitro.
Gene_expression (expressed) of NR2A in Granule cells
16) Confidence 0.66 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7704293 Disease Relevance 0 Pain Relevance 0.24
Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio.
Gene_expression (expression) of NR2A associated with withdrawal and morphine
17) Confidence 0.65 Published 2008 Journal Brain Res. Section Title Doc Link 18374314 Disease Relevance 0.07 Pain Relevance 0.99
Here, we examined whether and how morphine withdrawal influenced delayed-escape behaviour and NR2A/2B expression ratio of hippocampal synaptosomes.
Gene_expression (expression) of NR2A associated with withdrawal and morphine
18) Confidence 0.65 Published 2008 Journal Brain Res. Section Abstract Doc Link 18374314 Disease Relevance 0.07 Pain Relevance 0.84
We found that both delayed-escape behaviour and NR2A/2B expression ratio showed an inverted-U curve and peaked on 4-day withdrawal during a 20-day withdrawal period.
Gene_expression (expression) of NR2A associated with withdrawal
19) Confidence 0.65 Published 2008 Journal Brain Res. Section Abstract Doc Link 18374314 Disease Relevance 0.07 Pain Relevance 0.87
Consistently, genetic over-expression of NR2B C-terminal in the BLA, which interferes with the C-terminal mediated intracellular signaling, produced a severe deficit in auditory fear memory for five but not one CS-US pairing protocol, whereas over-expression of NR2A C-terminal produced a deficient memory for both protocols.
Gene_expression (expression) of NR2A in BLA associated with anxiety disorder and amygdala
20) Confidence 0.65 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.37 Pain Relevance 0.43

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