INT51635

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.17
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (LRTOMT) cytoplasm (LRTOMT)
Anatomy Link Frequency
neuronal 2
liver 1
brain 1
LRTOMT (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 9 100.00 Very High Very High Very High
Catechol-O-methyltransferase 4 100.00 Very High Very High Very High
withdrawal 2 99.14 Very High Very High Very High
antagonist 7 99.08 Very High Very High Very High
noradrenaline 2 98.92 Very High Very High Very High
Dopamine 8 98.76 Very High Very High Very High
tetrodotoxin 6 95.36 Very High Very High Very High
dopamine receptor 6 89.20 High High
agonist 5 68.08 Quite High
palliative 1 49.84 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 100.00 Very High Very High Very High
Parkinson's Disease 3 99.44 Very High Very High Very High
Parkinsonian Disorders 1 98.96 Very High Very High Very High
Tremor 4 94.60 High High
Muscle Rigidity 3 89.32 High High
Fever 6 88.56 High High
Syndrome 4 87.52 High High
Neuroleptic Malignant Syndrome 19 78.20 Quite High
Hemorrhage 14 76.04 Quite High
Hepatotoxicity 6 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
New approaches in Parkinsonian pharmacotherapy may be (1) inhibition of catechol-O-methyl-transferase influencing the metabolism of dopamine, (2) the use of budipine, which is assumed to be neuroprotective, with an effect especially on tremor, (3) the application of NADH with the postulated stimulation of the endogenous dopamine synthesis and (4) the revival of stereotaxic surgery with the lesion or the stimulation of certain brain areas, enabled by the development of new and more sensitive methods.
Negative_regulation (inhibition) of catechol-O-methyl-transferase in brain associated with tremor, parkinson's disease and dopamine
1) Confidence 0.41 Published 1997 Journal Fortschr Neurol Psychiatr Section Abstract Doc Link 9378450 Disease Relevance 0.32 Pain Relevance 0.09
OBJECTIVE: The aim of this investigation was to study the inhibition of 11 nonsteroidal anti-inflammatory drugs (NSAIDs) on the human liver phenol sulfotransferases (HL-PST) and catechol sulfotransferase (HL-CST).
Negative_regulation (inhibition) of catechol sulfotransferase in liver associated with inflammation and cinod
2) Confidence 0.13 Published 2000 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 10853883 Disease Relevance 0.17 Pain Relevance 0.28
It has also been described after the withdrawal of dopaminergic agents, such as L-dopa or inhibitors of catechol-o-methyl transferase, in patients affected by parkinsonian disorders (Friedman et al 1985; Iwuagwu et al 2000).
Negative_regulation (inhibitors) of catechol-o-methyl transferase associated with parkinsonian disorders and withdrawal
3) Confidence 0.08 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661629 Disease Relevance 0.67 Pain Relevance 0.16
Based on the model of the adrenergic neurone proposed earlier, the dynamics of nerve-pulse transmission after treatment with inhibitors of neuronal uptake and catechol-O-methyltransferase, alpha 1-adrenoceptor antagonists, changes in the concentration of Ca2+ ions in the external medium, the action of tetrodotoxin (TTX) and repetitive stimulation, are analysed.
Negative_regulation (inhibitors) of catechol-O-methyltransferase in neuronal associated with tetrodotoxin, catechol-o-methyltransferase and antagonist
4) Confidence 0.07 Published 1995 Journal Med Eng Phys Section Abstract Doc Link 7704341 Disease Relevance 0 Pain Relevance 0.45
The results of numerical simulation show that: the addition of drugs that inhibit neuronal uptake and catechol-O-methyltransferase cause the augmentation of noradrenaline action on post-synaptic structures and an increase in the amplitude of the generated inhibitory post-synaptic potential (IPSP); treatment with adrenergic antagonists reduces the amplitude of IPSP; decrease in the concentration of extracellular Ca2+ ions and application of TTX abolish the post-synaptic response.
Negative_regulation (inhibit) of catechol-O-methyltransferase in neuronal associated with tetrodotoxin, catechol-o-methyltransferase, antagonist and noradrenaline
5) Confidence 0.07 Published 1995 Journal Med Eng Phys Section Abstract Doc Link 7704341 Disease Relevance 0 Pain Relevance 0.51

General Comments

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