INT5164

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Context Info
Confidence 0.58
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 83
Total Number 86
Disease Relevance 55.01
Pain Relevance 7.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ldlr) transport (Ldlr) aging (Ldlr)
plasma membrane (Ldlr) lipid metabolic process (Ldlr) lysosome (Ldlr)
Anatomy Link Frequency
plasma 6
blood 4
heart 4
smooth muscle 1
hepatocytes 1
Ldlr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 6 99.98 Very High Very High Very High
Angina 68 99.68 Very High Very High Very High
Paracetamol 2 99.28 Very High Very High Very High
tolerance 16 98.52 Very High Very High Very High
Migraine 7 97.98 Very High Very High Very High
Bile 38 97.52 Very High Very High Very High
agonist 17 97.20 Very High Very High Very High
Duloxetine 84 95.36 Very High Very High Very High
antagonist 18 94.52 High High
cva 121 94.28 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 490 100.00 Very High Very High Very High
Hyperlipidemia 312 100.00 Very High Very High Very High
Nicotine Addiction 26 99.90 Very High Very High Very High
Increased Venous Pressure Under Development 85 99.88 Very High Very High Very High
Stroke 257 99.80 Very High Very High Very High
Cv General 3 Under Development 181 99.68 Very High Very High Very High
Insulin Resistance 6 99.68 Very High Very High Very High
Coronary Artery Disease 473 99.60 Very High Very High Very High
Atherosclerosis 200 99.40 Very High Very High Very High
Acute Coronary Syndrome 82 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas it seems clear that these patients should give up smoking and reduce low-density lipoprotein (LDL) cholesterol, there is uncertainty about the optimal antiplatelet regimen and antithrombotic treatment.
Negative_regulation (reduce) of low-density lipoprotein associated with nicotine addiction
1) Confidence 0.58 Published 2004 Journal Scand. Cardiovasc. J. Section Abstract Doc Link 15204230 Disease Relevance 0.29 Pain Relevance 0.10
Patients with myocardial infarction on thrombolytic therapy (n = 63) and patients with unstable angina (n = 33) had a decrease in low-density lipoprotein (LDL) cholesterol levels < or = 24 hours after admission (-12 +/- 20% and -6 +/- 23%, respectively), but these levels returned to baseline before discharge.
Negative_regulation (decrease) of low-density lipoprotein associated with angina and myocardial infarction
2) Confidence 0.58 Published 2002 Journal Am. J. Cardiol. Section Abstract Doc Link 11779514 Disease Relevance 0.55 Pain Relevance 0.19
Standard treatment (statin) with a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (pravastatin 40 mg/day) resulted in a 22% reduction in LDL cholesterol levels at 30 days compared with a 51% reduction with intensive therapy (atorvastatin 80 mg/day).
Negative_regulation (reduction) of LDL cholesterol
3) Confidence 0.58 Published 2005 Journal Am. J. Med. Section Abstract Doc Link 16356805 Disease Relevance 0.91 Pain Relevance 0.08
Recent Canadian lipid guidelines recommend that all high-risk patients receive medication to reduce low density lipoprotein cholesterol (LDL-C) below 2.5 mmol/L.
Negative_regulation (reduce) of low density lipoprotein cholesterol
4) Confidence 0.57 Published 2005 Journal Can J Cardiol Section Abstract Doc Link 15685308 Disease Relevance 0.56 Pain Relevance 0.06
After 24 weeks and compared with baseline, there were no significant changes in blood pressures, blood hematological and biochemical profiles, or folate and homocysteine levels in both groups, but there was a mild decrease in low density lipoprotein (LDL) cholesterol in both groups (p < 0.05).
Negative_regulation (decrease) of low density lipoprotein in blood
5) Confidence 0.57 Published 2009 Journal J Altern Complement Med Section Body Doc Link 19388864 Disease Relevance 0 Pain Relevance 0
Although there was no apparent relation between low-density lipoprotein (LDL) cholesterol levels before or during randomized treatment and short-term (4-month) risk of recurrent events, the degree of LDL cholesterol reduction with statin treatment after ACS may be related to longer-term event reduction.
Negative_regulation (reduction) of LDL cholesterol associated with acute coronary syndrome
6) Confidence 0.51 Published 2005 Journal Am. J. Cardiol. Section Abstract Doc Link 16126023 Disease Relevance 0.60 Pain Relevance 0.11
Between admission and the following morning, total and LDL-cholesterol decreased significantly by 7 and 10% respectively for MI and by 5 and 6% for UA.
Negative_regulation (decreased) of LDL-cholesterol
7) Confidence 0.45 Published 2002 Journal Ital Heart J Section Body Doc Link 12478816 Disease Relevance 0.13 Pain Relevance 0
Serum levels of total and LDL-cholesterol decreased significantly after admission, both in MI and UA patients.
Negative_regulation (decreased) of LDL-cholesterol
8) Confidence 0.45 Published 2002 Journal Ital Heart J Section Body Doc Link 12478816 Disease Relevance 0.15 Pain Relevance 0
Reductions in systolic and diastolic blood pressure readings average 6 to 9 mm Hg; decreases in total and low-density lipoprotein (LDL) cholesterol approximate 5 to 10 mg/dL; and increases in high-density lipoprotein (HDL) cholesterol approximate 2 mg/dL.
Negative_regulation (decreases) of low-density lipoprotein in blood associated with disorder of lipid metabolism
9) Confidence 0.43 Published 1997 Journal Ann Behav Med Section Abstract Doc Link 9603697 Disease Relevance 1.02 Pain Relevance 0.14
Picroliv from root and rhizome of Picrorhiza kurroa showed reversal of low density lipoprotein (LDL) binding to paracetamol-induced damaged hepatocytes of rats.
Negative_regulation (reversal) of low density lipoprotein in hepatocytes associated with paracetamol
10) Confidence 0.43 Published 1992 Journal Indian J. Biochem. Biophys. Section Abstract Doc Link 1289234 Disease Relevance 0 Pain Relevance 0.17
Guggulipid decreased the total cholesterol level by 11.7%, the low density lipoprotein cholesterol (LDL) by 12.5%, triglycerides by 12.0%, and the total cholesterol/high density lipoprotein (HDL) cholesterol ratio by 11.1% from the postdiet levels, whereas the levels were unchanged in the placebo group.
Negative_regulation (decreased) of low density lipoprotein cholesterol associated with disorder of lipid metabolism
11) Confidence 0.42 Published 1994 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 7848901 Disease Relevance 0.62 Pain Relevance 0
Cuban studies claim that 1 to 20 mg/day of the original PC supplement are effective at producing significant reductions in total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C).
Negative_regulation (reductions) of low density lipoprotein cholesterol associated with disorder of lipid metabolism
12) Confidence 0.42 Published 2010 Journal Crit Rev Food Sci Nutr Section Abstract Doc Link 20301014 Disease Relevance 0.27 Pain Relevance 0.08
Small reductions in plasma levels of total cholesterol, low density lipoprotein-cholesterol and triglycerides have been reported with rilmenidine.
Negative_regulation (reductions) of low density lipoprotein-cholesterol in plasma associated with disorder of lipid metabolism
13) Confidence 0.39 Published 2000 Journal Drugs Aging Section Abstract Doc Link 10984201 Disease Relevance 0.49 Pain Relevance 0.26
Catecholamines suppress the LDL receptor activity, thus leading to an increase in plasma cholesterol concentration.
Negative_regulation (suppress) of LDL receptor in plasma associated with catecholamine
14) Confidence 0.34 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455133 Disease Relevance 0.15 Pain Relevance 0.50
Colesevelam hydrochloride is a nonabsorbed lipid-lowering agent approved for use alone or in combination with hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors for the reduction of low-density-lipoprotein (LDL) cholesterol in patients with primary hypercholesterolemia.
Negative_regulation (reduction) of low-density-lipoprotein associated with hyperlipidemia
15) Confidence 0.33 Published 2002 Journal Am J Health Syst Pharm Section Abstract Doc Link 12040732 Disease Relevance 0.10 Pain Relevance 0.08
Policosanol significantly reduced total cholesterol (p < 0.0001) (15.8%), low-density lipoprotein (LDL)-cholesterol (21%) and the ratios of LDL-cholesterol to high-density lipoprotein (HDL)-cholesterol (15.8%) and cholesterol to HDL-cholesterol (11.5%).
Negative_regulation (reduced) of low-density lipoprotein associated with disorder of lipid metabolism
16) Confidence 0.32 Published 1999 Journal Int J Tissue React Section Abstract Doc Link 10645516 Disease Relevance 0.53 Pain Relevance 0
The plant stanol ester margarine BenecolĀ® (Raisio Group, Raisio, Finland), launched in Finland in 1995, is an example of a functional food that has been shown to lower effectively serum total and LDL-cholesterol levels in several interventions [5,6].
Negative_regulation (lower) of LDL-cholesterol
17) Confidence 0.32 Published 2005 Journal Nutr J Section Body Doc Link PMC1177987 Disease Relevance 0.21 Pain Relevance 0
Low-density lipoprotein cholesterol reduction to Week 26 [mean (SD)] in the amlodipine cohort was ?
Negative_regulation (reduction) of Low-density lipoprotein
18) Confidence 0.29 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2966969 Disease Relevance 0.50 Pain Relevance 0.08
Low-density lipoprotein reduction in high-risk patients: how low do you go?
Negative_regulation (reduction) of Low-density lipoprotein
19) Confidence 0.28 Published 2004 Journal Curr Atheroscler Rep Section Title Doc Link 15296700 Disease Relevance 0.52 Pain Relevance 0.12
Consequently, it is reasonable to assume that more aggressive reductions of low-density lipoprotein (LDL) cholesterol might result in even greater reductions of cardiovascular event rates and atheromatous plaque progression than heretofore observed.
Negative_regulation (reductions) of low-density lipoprotein in plaque associated with atherosclerosis
20) Confidence 0.28 Published 2004 Journal Curr Atheroscler Rep Section Abstract Doc Link 15296700 Disease Relevance 0.80 Pain Relevance 0.11

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