INT51646

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Context Info
Confidence 0.37
First Reported 1994
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.26
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL3) extracellular region (IL3) cell-cell signaling (IL3)
Anatomy Link Frequency
granulocyte 1
nasal 1
IL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 3 100.00 Very High Very High Very High
cytokine 10 98.42 Very High Very High Very High
Pain 3 92.96 High High
psoriasis 2 60.36 Quite High
Disease Link Frequency Relevance Heat
Headache 3 100.00 Very High Very High Very High
Exanthema 2 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 2 100.00 Very High Very High Very High
Ovarian Cancer 2 98.80 Very High Very High Very High
Toxicity 9 97.88 Very High Very High Very High
Myelodysplastic Syndromes 7 96.84 Very High Very High Very High
Capillary Leak Syndrome 2 94.56 High High
Pain 3 92.96 High High
Fever 2 92.40 High High
Sepsis 1 87.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A phase I trial of cyclosphosphamide and carboplatinum combined with interleukin-3 in women with advanced-stage ovarian cancer.
interleukin-3 Binding (combined) of associated with ovarian cancer
1) Confidence 0.37 Published 1995 Journal Gynecol. Oncol. Section Title Doc Link 7705673 Disease Relevance 0.41 Pain Relevance 0.06
We believe that sequential therapy with IL-3 and GM-CSF at these dose levels causes unacceptable toxicity in patients with MDS.
IL-3 Binding (therapy) of associated with toxicity and myelodysplastic syndromes
2) Confidence 0.08 Published 1994 Journal Blood Section Abstract Doc Link 8286736 Disease Relevance 1.19 Pain Relevance 0.09
A number of cytokines are used as haemopoietic growth factors and this review focuses on toxicities associated with granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), interleukin (IL)-1, IL-3, IL-4, IL-6 and macrophage colony-stimulating factor (M-CSF).
IL-3 Binding (associated) of in granulocyte associated with cytokine
3) Confidence 0.02 Published 1995 Journal Drug Saf Section Abstract Doc Link 8652081 Disease Relevance 0.40 Pain Relevance 0.17
More specific adverse events, also frequently considered as dose-limiting toxicities, include hypotension with IL-1, severe headache or skin rash with IL-3, and nasal congestion and gastroduodenal lesions with IL-4.
IL-3 Binding (hypotension) of in nasal associated with exanthema, pressure volume 2 under development and headache
4) Confidence 0.02 Published 1995 Journal Drug Saf Section Abstract Doc Link 8652081 Disease Relevance 1.27 Pain Relevance 0.25

General Comments

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