INT51656

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Context Info
Confidence 0.06
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 7.66
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lymph nodes 1
macrophages 1
plasma 1
Hivan1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 12 99.86 Very High Very High Very High
chemokine 13 99.40 Very High Very High Very High
cytokine 4 98.44 Very High Very High Very High
agonist 1 88.48 High High
withdrawal 4 82.24 Quite High
Inflammation 5 68.72 Quite High
abdominal pain 1 67.16 Quite High
Central nervous system 4 46.96 Quite Low
opioid receptor 1 27.60 Quite Low
antagonist 20 26.32 Quite Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 336 100.00 Very High Very High Very High
Cancer 261 99.52 Very High Very High Very High
Targeted Disruption 6 99.04 Very High Very High Very High
Infection 42 96.88 Very High Very High Very High
Lymphatic System Cancer 104 96.82 Very High Very High Very High
Lymphadenopathy 4 96.48 Very High Very High Very High
Severe Combined Immunodeficiency 9 95.32 Very High Very High Very High
Disease Progression 4 94.16 High High
Dementia 4 93.92 High High
Toxicity 7 85.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunosuppressive effect of morphine in an HIV-1 transactivator of transcription (TAT)-transgenic mouse model was investigated in order to elucidate possible mechanisms of human immunodeficiency virus (HIV)-1 disease progression.
Positive_regulation (transactivator) of HIV-1 associated with targeted disruption, acquired immune deficiency syndrome or hiv infection, disease progression and morphine
1) Confidence 0.06 Published 1994 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 7705968 Disease Relevance 0.75 Pain Relevance 0.31
Virologic failure was defined by any of the following: HIV-1 RNA >400 copies/mL by week 24 of randomized treatment or repeated detection (>400 copies/mL) after initial suppression to undetectable levels (<400 copies/mL) or a 3-fold or greater increase in plasma HIV-1 RNA level from the nadir at week 8 or later not attributable to intercurrent infection or vaccination.
Positive_regulation (increase) of HIV-1 in plasma associated with acquired immune deficiency syndrome or hiv infection and infection
2) Confidence 0.01 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1090576 Disease Relevance 1.41 Pain Relevance 0.11
Chemokine analogs can be engineered to enhance their anti-HIV activity (reviewed in (Hartley and Offord 2005)).
Positive_regulation (enhance) of HIV associated with chemokine and acquired immune deficiency syndrome or hiv infection
3) Confidence 0.01 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.56 Pain Relevance 0.22
Because HIV positive TAM typically express IL-10 and IL-6, cytokines not generally expressed by other forms of HIV infected macrophages (i.e. macrophages in HIV-associated dementia), the finding suggests that HIV indirectly contributes to lymphoma pathogenesis through the creation of tumorigenic microenvironments.
Positive_regulation (positive) of HIV in macrophages associated with lymphatic system cancer, dementia, acquired immune deficiency syndrome or hiv infection and cytokine
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780293 Disease Relevance 2.37 Pain Relevance 0.11
Similar results were found in both patients: 1) high-resolution phylogenetic analysis showed a significant degree of compartmentalization between lymphoma and non-lymphoma viral sub-populations while viral sub-populations from lymph nodes appeared to be intermixed within sequences from tumor and non-tumor tissues, 2) a 100-fold increase in the effective HIV population size in tumor versus non-tumor tissues was associated with the emergence of lymphadenopathy and aggressive metastatic ARL, and 3) HIV gene flow among lymph nodes, normal and metastatic tissues was non-random.
Positive_regulation (increase) of HIV in lymph nodes associated with lymphatic system cancer, lymphadenopathy, cancer and acquired immune deficiency syndrome or hiv infection
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2780293 Disease Relevance 2.39 Pain Relevance 0
Thus, in this trial, subjects in the GM-CSF group, irrespective of their initial CD4+ count, tended to have a modest increase in HIV RNA levels at the end of the 16-week randomized period.
Positive_regulation (increase) of HIV RNA associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.00 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 0.18 Pain Relevance 0

General Comments

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