INT5166

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Context Info
Confidence 0.48
First Reported 1988
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 14
Total Number 19
Disease Relevance 11.95
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ldlr) transport (Ldlr) aging (Ldlr)
plasma membrane (Ldlr) lipid metabolic process (Ldlr) lysosome (Ldlr)
Anatomy Link Frequency
hepatocytes 3
plasma 2
Blood 1
heart 1
ankle 1
Ldlr (Rattus norvegicus)
Ldlr - G188E (1) Ldlr - N291S (1)
Pain Link Frequency Relevance Heat
Paracetamol 6 99.84 Very High Very High Very High
Migraine 18 98.76 Very High Very High Very High
Restless leg syndrome 17 98.20 Very High Very High Very High
Angina 27 95.76 Very High Very High Very High
Pain 6 93.52 High High
cytokine 4 89.84 High High
antagonist 2 89.20 High High
Inflammation 8 86.96 High High
alcohol 1 81.36 Quite High
Serotonin 1 61.20 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 67 100.00 Very High Very High Very High
Nicotine Addiction 6 100.00 Very High Very High Very High
Obesity 4 100.00 Very High Very High Very High
Cardiovascular Disease 16 99.36 Very High Very High Very High
Cv Unclassified Under Development 4 99.28 Very High Very High Very High
Hyperlipoproteinemia Type Ii 10 99.24 Very High Very High Very High
Thrombosis 5 99.24 Very High Very High Very High
Coronary Artery Disease 35 99.08 Very High Very High Very High
Headache 6 98.76 Very High Very High Very High
Adhesions 2 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Picroliv from root and rhizome of Picrorhiza kurroa showed reversal of low density lipoprotein (LDL) binding to paracetamol-induced damaged hepatocytes of rats.
low density lipoprotein Binding (binding) of in hepatocytes associated with paracetamol
1) Confidence 0.48 Published 1992 Journal Indian J. Biochem. Biophys. Section Abstract Doc Link 1289234 Disease Relevance 0 Pain Relevance 0.17
Effect of picroliv on low density lipoprotein receptor binding of rat hepatocytes in hepatic damage induced by paracetamol.
low density lipoprotein Binding (binding) of in hepatocytes associated with paracetamol
2) Confidence 0.48 Published 1992 Journal Indian J. Biochem. Biophys. Section Title Doc Link 1289234 Disease Relevance 0 Pain Relevance 0.19
The effect of picroliv on enzyme levels, LDL receptor binding and lipids in damaged hepatocytes was found to be comparable to silymarin, a known hepatoprotective agent.
LDL receptor Binding (binding) of in hepatocytes
3) Confidence 0.48 Published 1992 Journal Indian J. Biochem. Biophys. Section Abstract Doc Link 1289234 Disease Relevance 0 Pain Relevance 0.16
Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine.
low-density lipoprotein receptor Binding (Investigation) of associated with migraine
4) Confidence 0.36 Published 2004 Journal J. Neurol. Sci. Section Title Doc Link 15546598 Disease Relevance 0.80 Pain Relevance 0.49
We performed a genetic association study with the LDL receptor gene (LDLR) on chromosome 19p13.2 in 360 migraine patients, 220 with migraine without aura (MO) and 140 with migraine with aura (MA), and 200 controls, by analysing two polymorphic markers, a G142A transition in exon 10 and a triallelic (TA)n repeat in exon 18.
LDLR Spec (analysing) Binding (association) of associated with migraine with aura, migraine and migraine without aura
5) Confidence 0.36 Published 2003 Journal J. Neurol. Sci. Section Abstract Doc Link 12873747 Disease Relevance 0.90 Pain Relevance 0.51
We performed a genetic association study with the LDL receptor gene (LDLR) on chromosome 19p13.2 in 360 migraine patients, 220 with migraine without aura (MO) and 140 with migraine with aura (MA), and 200 controls, by analysing two polymorphic markers, a G142A transition in exon 10 and a triallelic (TA)n repeat in exon 18.
LDL receptor gene Spec (analysing) Binding (association) of associated with migraine with aura, migraine and migraine without aura
6) Confidence 0.36 Published 2003 Journal J. Neurol. Sci. Section Abstract Doc Link 12873747 Disease Relevance 0.90 Pain Relevance 0.51
Recent evidence suggests that lowering low-density lipoprotein (LDL)-cholesterol favorably influences pathophysiological mechanisms that may be intimately involved in the genesis of acute coronary syndromes [3,4,5].
low-density lipoprotein Binding (lowering) of associated with acute coronary syndrome
7) Confidence 0.19 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59635 Disease Relevance 0.54 Pain Relevance 0.09
In this study we examined the association of lipid parameters and in particular low density lipoprotein (LDL) particle size, with the presence of PVD in subjects with and without NIDDM. 41 NIDDM patients and 31 non-diabetic subjects with PVD in the absence of rest pain or ulceration, defined by ankle-brachial index measurements and duplex scanning, were compared with 41 NIDDM and 31 euglycemic control subjects of comparable age and sex, without PVD.
low density lipoprotein Spec (examined) Binding (association) of in ankle associated with pain, diabetes mellitus and peripheral arterial disease
8) Confidence 0.16 Published 1998 Journal Atherosclerosis Section Abstract Doc Link 9544725 Disease Relevance 1.84 Pain Relevance 0.09
Previous studies documented that serum LDL-C reduction is due to inhibition of hepatic apoB secretion, which is the main apolipoprotein in LDL particles that is recognized by the LDL receptor, and that cholesterol ester availability may be important in regulating apo B secretion.
LDL receptor Binding (recognized) of associated with disorder of lipid metabolism
9) Confidence 0.13 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC1266394 Disease Relevance 0.59 Pain Relevance 0
The second is assigning a target for LDL-cholesterol that is appropriate to the level of risk identified by the clinical data.
LDL-cholesterol Binding (target) of
10) Confidence 0.10 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988621 Disease Relevance 0.15 Pain Relevance 0
Data tabulated from charts for routine care were analyzed by DZ to assign a level of risk and a target for LDL-cholesterol according to NCEP guidelines.


LDL-cholesterol Binding (target) of
11) Confidence 0.09 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988621 Disease Relevance 0 Pain Relevance 0
The CLEOS® program collects historical information by direct interview of the patient and automatically analyzes these data to stratify risk and output a target for LDL-cholesterol appropriate for level of risk.
LDL-cholesterol Binding (target) of
12) Confidence 0.09 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988621 Disease Relevance 0.05 Pain Relevance 0
Lack of normal endothelial function results in diminished capacity to dilate, and sometimes even in a shift from dilator to constrictor effects, paralleled by an increased tendency for platelet adhesion, activation, and thrombosis, which is still enhanced when plasma low density lipoprotein (LDL) is augmented.
low density lipoprotein Binding (augmented) of in plasma associated with thrombosis and adhesions
13) Confidence 0.04 Published 1988 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 3154691 Disease Relevance 0.33 Pain Relevance 0.17
In the present study, the association of the heterozygous forms of low-density lipoprotein receptor gene mutations causing FH as well as of LPL gene mutations causing (P207L and G188E) or not causing (D9N and N291S) complete loss of LPL activity with angiographically assessed CAD was estimated in a cohort of 412 French Canadian men aged <60 years who consecutively underwent coronary angiography for the investigation of retrosternal pain.
low-density lipoprotein receptor gene (N291S, G188E) Binding (association) of associated with pain, coronary artery disease and hyperlipoproteinemia type ii
14) Confidence 0.04 Published 1998 Journal Am. J. Cardiol. Section Abstract Doc Link 9708657 Disease Relevance 1.07 Pain Relevance 0.09
Blood pressure, low density lipoprotein (LDL)-cholesterol and the apolipoproteins A1 and B rose while high density lipoprotein (HDL)-cholesterol, the HDL-cholesterol/apolipoprotein A1 and the LDL-cholesterol/apolipoprotein B ratios decreased significantly with increasing exposure.
low density lipoprotein Binding (rose) of in Blood associated with disorder of lipid metabolism
15) Confidence 0.04 Published 1992 Journal Int J Epidemiol Section Abstract Doc Link 1521980 Disease Relevance 1.32 Pain Relevance 0.23
Although there were no significant correlations between RI and %PA or %PV, and although %PA but not %PV in the P group was significantly higher than that in the NP group, %PV was significantly associated with plasma low-density lipoprotein cholesterol (LDL-C) and diastolic blood pressure, but not adiponectin, in all patients.
plasma low-density lipoprotein cholesterol Binding (associated) of in plasma
16) Confidence 0.03 Published 2008 Journal Hypertens. Res. Section Abstract Doc Link 19015595 Disease Relevance 0.22 Pain Relevance 0.14
like low-density lipoprotein (LDL) which can enter the vessel wall and deposit
low-density lipoprotein Binding (enter) of
17) Confidence 0.03 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.78 Pain Relevance 0.15
BACKGROUND: The relationship of lipoprotein (a) [Lp(a)] concentrations with risk of coronary heart disease needs clarification, especially for threshold values for increased risk and for possible interactions with LDL-cholesterol concentrations and apolipoprotein (a) [apo(a)] size polymorphism.
LDL-cholesterol Binding (interactions) of in heart associated with coronary artery disease and disorder of lipid metabolism
18) Confidence 0.00 Published 2004 Journal Clin. Chem. Section Abstract Doc Link 15155542 Disease Relevance 0.42 Pain Relevance 0.16
Total and LDL-cholesterol, smoking, body mass index, fibrinogen, coagulation factor VIIc, apolipoprotein A-I, apolipoprotein B and lipoprotein(a) were not associated with prevalent CVD.
LDL-cholesterol Binding (associated) of in body associated with nicotine addiction, cardiovascular disease, obesity and disorder of lipid metabolism
19) Confidence 0.00 Published 1993 Journal Atherosclerosis Section Abstract Doc Link 8141850 Disease Relevance 2.04 Pain Relevance 0.16

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