INT51679

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.29
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 7.21
Pain Relevance 4.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LTB4R) signal transducer activity (LTB4R)
Anatomy Link Frequency
macrophages 5
stomach 3
PMNs 2
blood 1
monocytes 1
LTB4R (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 65 99.40 Very High Very High Very High
diclofenac 4 99.12 Very High Very High Very High
cINOD 70 98.88 Very High Very High Very High
licofelone 4 98.36 Very High Very High Very High
Inflammation 128 97.40 Very High Very High Very High
Inflammatory response 6 94.32 High High
dexamethasone 42 90.88 High High
Paracetamol 4 86.16 High High
Osteoarthritis 315 82.72 Quite High
Eae 2 79.44 Quite High
Disease Link Frequency Relevance Heat
Occupational Lung Diseases 74 99.56 Very High Very High Very High
Coagulation Disorder 1 99.28 Very High Very High Very High
Acute Coronary Syndrome 9 98.72 Very High Very High Very High
INFLAMMATION 156 97.40 Very High Very High Very High
Asthma 209 96.64 Very High Very High Very High
Autoimmune Disease 1 89.00 High High
Injury 8 88.88 High High
Cardiovascular Disease 6 87.44 High High
Ulcers 8 86.40 High High
Osteoarthritis 318 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Out of the other NSAIDs, diclofenac (which is chemically related to fenamates) suppressed degranulation as well as LTB4 and PAF production.
Negative_regulation (suppressed) of Gene_expression (production) of LTB4 associated with cinod and diclofenac
1) Confidence 0.29 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.13 Pain Relevance 0.81
Indomethacin inhibited LTB4 and PAF synthesis whereas ketoprofen reduced degranulation.
Negative_regulation (inhibited) of Gene_expression (synthesis) of LTB4
2) Confidence 0.29 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.13 Pain Relevance 0.81
Thus, the inhibition of LTB4 synthesis demonstrates potential for targeting chronic, autoimmune-driven inflammation.
Negative_regulation (inhibition) of Gene_expression (synthesis) of LTB4 associated with inflammation
3) Confidence 0.11 Published 2009 Journal Curr Opin Investig Drugs Section Abstract Doc Link 19876785 Disease Relevance 0.88 Pain Relevance 0.24
Tolfenamic acid inhibited LTB4 production in PMNs as well as FMLP- and LTB4-induced PMN migration (IC50 values 23 +/- 3, 39 +/- 11, and 68 +/- 13 microM, respectively), whereas flunixin inhibited these cell functions only with the highest concentration tested (100 microM).
Negative_regulation (inhibited) of Gene_expression (production) of LTB4 in PMNs
4) Confidence 0.05 Published 1993 Journal Inflammation Section Abstract Doc Link 8406686 Disease Relevance 0.24 Pain Relevance 0.09
Basal levels of LTB4 were decreased in severe asthmatics compared to normal subjects (p < 0.05), but not to non-severe asthma.
Neg (not) Negative_regulation (decreased) of Gene_expression (levels) of LTB4 associated with asthma and occupational lung diseases
5) Confidence 0.02 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2894769 Disease Relevance 1.03 Pain Relevance 0.23
Decreased LXA4 and increased LTB4 generation plus impaired corticosteroid sensitivity of LPS-induced LTB4 but not of LXA4 support a role for AMs in establishing a pro-inflammatory balance in severe asthma.



Negative_regulation (Decreased) of Gene_expression (generation) of LTB4 associated with asthma, corticosteroid and inflammation
6) Confidence 0.02 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2894769 Disease Relevance 1.08 Pain Relevance 0.27
Our simulation showed that licofelone can maintain the balance between PGI2 and TXA2, and at the same time effectively reduce PGE2 and LTB4 production.


Negative_regulation (reduce) of Gene_expression (production) of LTB4 associated with licofelone
7) Confidence 0.01 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.23 Pain Relevance 0.43
The ACS trial demonstrated a statistically significant, dose-dependent inhibition of ex vivo-stimulated LTB4 production at 12 weeks.
Negative_regulation (inhibition) of Gene_expression (production) of LTB4 associated with acute coronary syndrome
8) Confidence 0.01 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817543 Disease Relevance 1.05 Pain Relevance 0.28
ML 3000 reduces gastric prostaglandin E2 synthesis in rat stomach and blood, although significant inhibition of gastric or blood leukotriene B4 synthesis was not detected [6].
Negative_regulation (inhibition) of Gene_expression (synthesis) of leukotriene B4 in stomach
9) Confidence 0.01 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC368434 Disease Relevance 0.39 Pain Relevance 0.37
Indeed, PGE2-driven IL-10 synthesis in monocytes/macrophages in vitro has been shown to inhibit LTB4 production by these cells [24], whereas in neutrophils IL-18 stimulates the synthesis of LTs [32].
Negative_regulation (inhibit) of Gene_expression (production) of LTB4 in macrophages
10) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.59 Pain Relevance 0.29
In macrophages, the shunt from the COX to the 5-LO pathway is linked with a variable production of IL-10; as PGE2 levels rise, IL-10 levels increase and inhibit the synthesis of LTB4 [24].
Negative_regulation (inhibit) of Gene_expression (synthesis) of LTB4 in macrophages
11) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.49 Pain Relevance 0.24
ML 3000 reduces gastric prostaglandin E2 synthesis in rat stomach and blood, although significant inhibition of gastric or blood leukotriene B4 synthesis was not detected [6].
Negative_regulation (inhibition) of in blood Gene_expression (synthesis) of leukotriene B4 in stomach
12) Confidence 0.00 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC368434 Disease Relevance 0.39 Pain Relevance 0.37
Indeed, PGE2-driven IL-10 synthesis in monocytes/macrophages in vitro has been shown to inhibit LTB4 production by these cells [24], whereas in neutrophils IL-18 stimulates the synthesis of LTs [32].
Negative_regulation (inhibit) of in monocytes Gene_expression (production) of LTB4 in macrophages
13) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.59 Pain Relevance 0.29

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox