INT51680

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Context Info
Confidence 0.64
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 3.69
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (PTAFR) plasma membrane (PTAFR) nucleus (PTAFR)
signal transducer activity (PTAFR)
Anatomy Link Frequency
platelet 2
embryos 1
PTAFR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 13 100.00 Very High Very High Very High
Potency 51 99.92 Very High Very High Very High
diclofenac 2 98.90 Very High Very High Very High
cINOD 8 98.66 Very High Very High Very High
ischemia 2 97.48 Very High Very High Very High
antagonist 38 90.92 High High
Angina 6 90.44 High High
cytokine 54 86.64 High High
Crohn's disease 2 86.00 High High
Inflammation 38 83.68 Quite High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 2 97.48 Very High Very High Very High
Neonatal Necrotizing Enterocolitis 68 96.48 Very High Very High Very High
Cv General 3 Under Development 6 90.44 High High
Inflammatory Bowel Disease 4 87.16 High High
Disease 8 86.00 High High
Ulcers 2 85.16 High High
Asthma 4 84.16 Quite High
INFLAMMATION 42 83.68 Quite High
Mucositis 4 83.52 Quite High
Injury 20 82.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAF or its stabilized analog, methyl carbamyl (mc)PAF (EC50=0.8 nM), rapidly mobilized [Ca2+]i, which peaked within 30–60 s and remained elevated for 3 min.
Protein_catabolism (stabilized) of PAF associated with potency
1) Confidence 0.64 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2693427 Disease Relevance 0 Pain Relevance 0.38
We have also shown that giving the PAF-degrading enzyme PAF-acetylhydrolase (PAF-AH) with enteral feedings prevents the initiation of experimental NEC in this rat model [7].
Protein_catabolism (degrading) of PAF associated with neonatal necrotizing enterocolitis
2) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 1.58 Pain Relevance 0.21
We have also shown that giving the PAF-degrading enzyme PAF-acetylhydrolase (PAF-AH) with enteral feedings prevents the initiation of experimental NEC in this rat model [7].
Protein_catabolism (degrading) of PAF associated with neonatal necrotizing enterocolitis
3) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 1.58 Pain Relevance 0.21
PAF or its stabilized analog, methyl carbamyl (mc)PAF (EC50=0.8 nM), rapidly mobilized [Ca2+]i, which peaked within 30–60 s and remained elevated for 3 min.
Protein_catabolism (stabilized) of PAF associated with potency
4) Confidence 0.55 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2693427 Disease Relevance 0 Pain Relevance 0.38
Out of the other NSAIDs, diclofenac (which is chemically related to fenamates) suppressed degranulation as well as LTB4 and PAF production.
Protein_catabolism (degranulation) of PAF associated with cinod and diclofenac
5) Confidence 0.38 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.13 Pain Relevance 0.81
Platelet-activating factor (PAF) is a potent platelet agonist which is degraded and inactivated by PAF-acetylhydrolase (PAF-AH).
Protein_catabolism (degraded) of PAF in platelet associated with agonist
6) Confidence 0.17 Published 1999 Journal Cardiovasc. Res. Section Abstract Doc Link 10536703 Disease Relevance 0.16 Pain Relevance 0.30
Platelet-activating factor (PAF) is a potent platelet agonist which is degraded and inactivated by PAF-acetylhydrolase (PAF-AH).
Protein_catabolism (degraded) of PAF in platelet associated with agonist
7) Confidence 0.17 Published 1999 Journal Cardiovasc. Res. Section Abstract Doc Link 10536703 Disease Relevance 0.17 Pain Relevance 0.30
Human embryos likewise release PAF in vitro, and human oviducts synthesize both the PAF receptor and PAF acetylhydrolase, which degrades PAF, further supporting a role for PAF in the embryo-oviductal dialogue [90].
Protein_catabolism (degrades) of PAF in embryos
8) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266059 Disease Relevance 0.07 Pain Relevance 0

General Comments

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