INT51683

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Context Info
Confidence 0.60
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 5.06
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (PTAFR) plasma membrane (PTAFR) nucleus (PTAFR)
signal transducer activity (PTAFR)
Anatomy Link Frequency
platelet 14
eosinophils 4
paneth cells 2
PTAFR (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 28 100.00 Very High Very High Very High
diclofenac 4 100.00 Very High Very High Very High
Paracetamol 4 100.00 Very High Very High Very High
addiction 2 100.00 Very High Very High Very High
agonist 2 96.80 Very High Very High Very High
Inflammation 81 95.92 Very High Very High Very High
adenocard 4 86.92 High High
Kinase C 5 81.84 Quite High
cytokine 14 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 44 100.00 Very High Very High Very High
Hypotension 2 98.68 Very High Very High Very High
INFLAMMATION 98 97.88 Very High Very High Very High
Common Cold 6 96.92 Very High Very High Very High
Hypoxia 4 96.00 Very High Very High Very High
Endotoxemia 2 95.64 Very High Very High Very High
Injury 21 94.96 High High
Disease 37 94.88 High High
Influenza Virus Infection 23 92.40 High High
Infection 43 91.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to compare the effects of chemically different NSAIDs (diclofenac, indomethacin, ketoprofen, paracetamol, piroxicam and four fenamates: flufenamic, meclofenamic, mefenamic and tolfenamic acids) on human polymorphonuclear leukocyte (PMN) functions, i.e. calcium ionophore A23187-triggered degranulation, leukotriene B4 (LTB4) release, platelet-activating factor (PAF) production and migration towards LTB4.
Regulation (effects) of Gene_expression (production) of PAF in platelet associated with paracetamol, cinod and diclofenac
1) Confidence 0.60 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.17 Pain Relevance 0.60
Andrographolide, an active principle of the Chinese drug Andrographis paniculata, used for prevention and treatment of common cold in Scandinavia and known as an antiinflammatory, antiviral, antithrombotic, hypotensive and antiatherosclerotic drug, was investigated for its suggested influence on the biosynthesis of eicosanoids and the platelet-activating factor (PAF).
Regulation (influence) of Gene_expression (biosynthesis) of PAF in platelet associated with common cold, inflammation and hypotension
2) Confidence 0.45 Published 1999 Journal Phytomedicine Section Abstract Doc Link 10228608 Disease Relevance 0.37 Pain Relevance 0.07
Andrographolide, an active principle of the Chinese drug Andrographis paniculata, used for prevention and treatment of common cold in Scandinavia and known as an antiinflammatory, antiviral, antithrombotic, hypotensive and antiatherosclerotic drug, was investigated for its suggested influence on the biosynthesis of eicosanoids and the platelet-activating factor (PAF).
Regulation (influence) of Gene_expression (biosynthesis) of platelet-activating factor in platelet associated with common cold, inflammation and hypotension
3) Confidence 0.45 Published 1999 Journal Phytomedicine Section Abstract Doc Link 10228608 Disease Relevance 0.36 Pain Relevance 0.07
The aim of the present study was to compare the effects of chemically different NSAIDs (diclofenac, indomethacin, ketoprofen, paracetamol, piroxicam and four fenamates: flufenamic, meclofenamic, mefenamic and tolfenamic acids) on human polymorphonuclear leukocyte (PMN) functions, i.e. calcium ionophore A23187-triggered degranulation, leukotriene B4 (LTB4) release, platelet-activating factor (PAF) production and migration towards LTB4.
Regulation (effects) of Gene_expression (production) of platelet-activating factor in platelet associated with paracetamol, cinod and diclofenac
4) Confidence 0.44 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.17 Pain Relevance 0.60
The effect of salmeterol and nimesulide on chemotaxis and synthesis of PAF and LTC4 by human eosinophils.
Regulation (effect) of Gene_expression (synthesis) of PAF in eosinophils
5) Confidence 0.44 Published 1996 Journal Eur Respir J Suppl Section Title Doc Link 8871060 Disease Relevance 0.09 Pain Relevance 0.21
In the present study, we have, therefore, measured the effect of salmeterol and nimesulide on two important human eosinophil functions: chemotaxis; and synthesis of PAF and leukotriene C4 (LTC4).
Regulation (effect) of Gene_expression (synthesis) of PAF in eosinophil
6) Confidence 0.44 Published 1996 Journal Eur Respir J Suppl Section Abstract Doc Link 8871060 Disease Relevance 0.08 Pain Relevance 0.19
B binding sites [29], it is not surprising that we observed a dependence of PAF-induced TLR4 gene expression on NF-?
Regulation (dependence) of Gene_expression (expression) of PAF-induced associated with addiction
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.37 Pain Relevance 0.13
The secreted form of PLA2-II, responsible for the extracellular production of PAF, is expressed by many cell types including intestinal paneth cells and its release is triggered by hypoxia, endotoxemia, and trauma among other stimuli.
Regulation (responsible) of Gene_expression (production) of PAF in paneth cells associated with endotoxemia, hypoxia and injury
8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 1.18 Pain Relevance 0.07
Current therapies include NSAIDs' that inhibit cyclooxygenases (COX-1, COX-2) but have no effect on the production of leukotrienes or platelet activating factor (PAF).
Neg (no) Regulation (effect) of Gene_expression (production) of PAF in platelet associated with cinod
9) Confidence 0.28 Published 2005 Journal Curr. Med. Chem. Section Abstract Doc Link 16378502 Disease Relevance 0.55 Pain Relevance 0.27
Current therapies include NSAIDs' that inhibit cyclooxygenases (COX-1, COX-2) but have no effect on the production of leukotrienes or platelet activating factor (PAF).
Neg (no) Regulation (effect) of Gene_expression (production) of platelet activating factor in platelet associated with cinod
10) Confidence 0.28 Published 2005 Journal Curr. Med. Chem. Section Abstract Doc Link 16378502 Disease Relevance 0.55 Pain Relevance 0.27
Similar results were obtained with NF177 (Fig. 5), reaching higher inhibition effects using PAF and IL-1-?
Regulation (effects) of Gene_expression (using) of PAF
11) Confidence 0.06 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.19 Pain Relevance 0.11
More recently, it was shown that URT viruses can induce up-regulated expression of carcinoembryonic antigen-related cell adhesion molecule 1, ICAM1, and platelet-activating receptor, additional eukaryotic receptors known to be used for adherence by multiple human mucosal pathogens [242526].
Regulation (regulated) of Gene_expression (expression) of platelet-activating receptor in platelet associated with adhesions
12) Confidence 0.00 Published 2010 Journal J Leukoc Biol Section Body Doc Link PMC2812561 Disease Relevance 0.97 Pain Relevance 0

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