INT51685

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1993
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 87
Total Number 106
Disease Relevance 68.69
Pain Relevance 31.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LTB4R) signal transducer activity (LTB4R)
Anatomy Link Frequency
osteoblasts 10
macrophages 5
chondrocytes 4
neutrophils 4
leukocytes 4
LTB4R (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 102 99.92 Very High Very High Very High
Inflammation 1628 99.86 Very High Very High Very High
Osteoarthritis 2797 99.84 Very High Very High Very High
corticosteroid 598 99.64 Very High Very High Very High
licofelone 336 99.48 Very High Very High Very High
COX-2 inhibitor 156 99.48 Very High Very High Very High
dexamethasone 378 99.40 Very High Very High Very High
cINOD 546 99.36 Very High Very High Very High
diclofenac 29 98.60 Very High Very High Very High
cytokine 136 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1972 99.86 Very High Very High Very High
Osteoarthritis 2860 99.84 Very High Very High Very High
Occupational Lung Diseases 666 99.76 Very High Very High Very High
Asthma 1945 99.62 Very High Very High Very High
Hypersensitivity 45 99.08 Very High Very High Very High
Coagulation Disorder 4 98.88 Very High Very High Very High
Disease 892 98.64 Very High Very High Very High
Arthritis 64 98.56 Very High Very High Very High
Acute Coronary Syndrome 36 98.06 Very High Very High Very High
Nasal Polyps 240 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this study was therefore to investigate the presence of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in the masseter muscle and plasma and their relation to myalgia.
Spec (investigate) Gene_expression (presence) of LTB4 in muscle associated with myalgia
1) Confidence 0.58 Published 2001 Journal Acta Odontol. Scand. Section Abstract Doc Link 11831483 Disease Relevance 0.97 Pain Relevance 0.64
LTB(4) receptors BLT1 and BLT2 were present in normal and OA osteoblasts.
Gene_expression (present) of BLT1 in osteoblasts
2) Confidence 0.58 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12124864 Disease Relevance 0 Pain Relevance 0
LTB4 levels in the sinuses inoculated with bacteria tended to be higher; however, statistical analysis did not reveal significant differences between the experimental and control groups.
Gene_expression (levels) of LTB4
3) Confidence 0.56 Published 2001 Journal Am J Rhinol Section Abstract Doc Link 11258655 Disease Relevance 0.76 Pain Relevance 0.09
PGE2 and LTB4 were detectable in the plasma of all groups.
Gene_expression (detectable) of LTB4 in PGE2
4) Confidence 0.52 Published 2001 Journal Acta Odontol. Scand. Section Abstract Doc Link 11831483 Disease Relevance 1.33 Pain Relevance 1.00
In conclusion, both PGE2 and LTB4 were found in the human masseter muscle.
Gene_expression (found) of LTB4 in PGE2
5) Confidence 0.52 Published 2001 Journal Acta Odontol. Scand. Section Abstract Doc Link 11831483 Disease Relevance 1.26 Pain Relevance 0.94
Out of the other NSAIDs, diclofenac (which is chemically related to fenamates) suppressed degranulation as well as LTB4 and PAF production.
Gene_expression (production) of LTB4 associated with cinod and diclofenac
6) Confidence 0.52 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.13 Pain Relevance 0.80
Indomethacin inhibited LTB4 and PAF synthesis whereas ketoprofen reduced degranulation.
Gene_expression (synthesis) of LTB4
7) Confidence 0.52 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.13 Pain Relevance 0.81
In human peripheral blood leukocytes, neutrophils and eosinophils express significant amounts of both BLT1 and BLT2, whereas mononuclear cells express BLT2 but minimal BLT1 [8].
Gene_expression (express) of BLT1 in neutrophils
8) Confidence 0.49 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.74 Pain Relevance 0.26
BLT1 is expressed primarily in leukocytes, human BLT2 is present in most human tissues [7,8].
Gene_expression (expressed) of BLT1 in leukocytes
9) Confidence 0.49 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.74 Pain Relevance 0.28
although this effect is less potent than the LTB4 and PPAR?
Gene_expression (potent) of LTB4
10) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.52 Pain Relevance 0.16
well as leukotriene antagonists, because the 5-LOX products, leukotrienes (LTB4,
Gene_expression (products) of LTB4 associated with antagonist
11) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.57 Pain Relevance 0.18
Several synthetic LTB4 receptor
Gene_expression (synthetic) of LTB4
12) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.28 Pain Relevance 0.22
Several synthetic LTB4 receptor
Gene_expression (Several) of LTB4
13) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.28 Pain Relevance 0.22
However, there is also evidence in favor of BLT1 being the
Gene_expression (being) of BLT1
14) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.56 Pain Relevance 0.20
Separate lines of research have identified the 5-lipoxygenase/leukotriene B4 receptor pathway and the PPAR?
Gene_expression (pathway) of leukotriene B4 receptor
15) Confidence 0.46 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2631651 Disease Relevance 0.59 Pain Relevance 0.11
The aim of the present study was to compare the effects of chemically different NSAIDs (diclofenac, indomethacin, ketoprofen, paracetamol, piroxicam and four fenamates: flufenamic, meclofenamic, mefenamic and tolfenamic acids) on human polymorphonuclear leukocyte (PMN) functions, i.e. calcium ionophore A23187-triggered degranulation, leukotriene B4 (LTB4) release, platelet-activating factor (PAF) production and migration towards LTB4.
Gene_expression (production) of LTB4 in platelet associated with paracetamol, cinod and diclofenac
16) Confidence 0.45 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.16 Pain Relevance 0.57
In human peripheral blood leukocytes, neutrophils and eosinophils express significant amounts of both BLT1 and BLT2, whereas mononuclear cells express BLT2 but minimal BLT1 [8].
Gene_expression (express) of BLT1 in neutrophils
17) Confidence 0.43 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.73 Pain Relevance 0.26
The aim of the present study was to compare the effects of chemically different NSAIDs (diclofenac, indomethacin, ketoprofen, paracetamol, piroxicam and four fenamates: flufenamic, meclofenamic, mefenamic and tolfenamic acids) on human polymorphonuclear leukocyte (PMN) functions, i.e. calcium ionophore A23187-triggered degranulation, leukotriene B4 (LTB4) release, platelet-activating factor (PAF) production and migration towards LTB4.
Gene_expression (migration) of LTB4 in platelet associated with paracetamol, cinod and diclofenac
18) Confidence 0.39 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.16 Pain Relevance 0.57
However are in contrast with other reports showing increased levels of LTB4 and BLT receptors in allergic versus non-allergic nasal polyp patients [10].
Gene_expression (levels) of LTB4 in nasal associated with hypersensitivity and nasal polyps
19) Confidence 0.38 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.34 Pain Relevance 0.12
Concentrations of PGE2, LTC4/D4/E4, LTB4 and sol-IL-5R?
Gene_expression (Concentrations) of LTB4
20) Confidence 0.38 Published 2006 Journal Respir Res Section Abstract Doc Link PMC1481584 Disease Relevance 1.11 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox