INT51694

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Context Info
Confidence 0.37
First Reported 1993
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.67
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Es2)
Anatomy Link Frequency
raphe magnus nucleus 2
inhibitory interneurons 2
Es2 (Mus musculus)
Pain Link Frequency Relevance Heat
hyperexcitability 1 99.38 Very High Very High Very High
headache 6 98.80 Very High Very High Very High
Raphe magnus 1 98.16 Very High Very High Very High
aspirin 1 97.44 Very High Very High Very High
Central grey 1 94.96 High High
antagonist 1 93.16 High High
opioid receptor 1 92.24 High High
narcan 1 88.60 High High
Migraine 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Headache 6 98.80 Very High Very High Very High
Urological Neuroanatomy 1 94.96 High High
Migraine Without Aura 3 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They suggest that the changes observed in tension-type headache are due to hyperexcitability of the reticular nuclei which inhibit the medullary inhibitory interneurons mediating ES2.
Negative_regulation (inhibit) of Positive_regulation (mediating) of ES2 in inhibitory interneurons associated with headache and hyperexcitability
1) Confidence 0.37 Published 1994 Journal Pain Section Abstract Doc Link 7708406 Disease Relevance 0.58 Pain Relevance 0.49
These results suggest that inhibitory brain-stem interneurons mediating temporalis ES2 are inhibited by serotonergic afferents, probably from the raphe magnus nucleus, and that the latter receives an excitatory input from the periaqueductal gray matter and other limbic structures, in part via opioid receptors.
Negative_regulation (inhibited) of Positive_regulation (mediating) of ES2 in raphe magnus nucleus associated with raphe magnus, opioid receptor and central grey
2) Confidence 0.36 Published 1993 Journal Cephalalgia Section Abstract Doc Link 8448785 Disease Relevance 0.09 Pain Relevance 0.28

General Comments

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