INT51698

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Context Info
Confidence 0.68
First Reported 1994
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 44
Total Number 50
Disease Relevance 14.02
Pain Relevance 32.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
spinal cord 8
lamina 6
neurons 4
spinal cord dorsal horn 4
dorsal horn 3
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 948 100.00 Very High Very High Very High
Spinal cord 122 100.00 Very High Very High Very High
Morphine 121 100.00 Very High Very High Very High
Dorsal horn 40 100.00 Very High Very High Very High
Glutamate 31 100.00 Very High Very High Very High
excitatory amino acid 26 100.00 Very High Very High Very High
Root ganglion neuron 3 100.00 Very High Very High Very High
Thermal hyperalgesia 30 99.82 Very High Very High Very High
Endep 14 99.70 Very High Very High Very High
intrathecal 42 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 37 100.00 Very High Very High Very High
Hydrocephalus 22 100.00 Very High Very High Very High
Ganglion Cysts 3 100.00 Very High Very High Very High
Hyperalgesia 41 99.82 Very High Very High Very High
Nociception 70 99.80 Very High Very High Very High
Poisoning 63 99.70 Very High Very High Very High
Syndrome 14 99.62 Very High Very High Very High
Neuropathic Pain 41 99.44 Very High Very High Very High
Coronary Heart Disease 16 98.00 Very High Very High Very High
Bordatella Infection 19 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of epsilon and gamma PKC and the contributions of these isozymes in formalin-induced nociception was examined in postnatal day 7, 15, and 21 rats. epsilonPKC expression in dorsal root ganglion neurons and gammaPKC expression in lamina II of the spinal cord increased from the first to the third postnatal week.
Positive_regulation (increased) of Gene_expression (expression) of gammaPKC in lamina associated with ganglion cysts, nociception, kinase c, root ganglion neuron and spinal cord
1) Confidence 0.68 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14762097 Disease Relevance 0.45 Pain Relevance 0.60
Expression of epsilon and gamma PKC and the contributions of these isozymes in formalin-induced nociception was examined in postnatal day 7, 15, and 21 rats. epsilonPKC expression in dorsal root ganglion neurons and gammaPKC expression in lamina II of the spinal cord increased from the first to the third postnatal week.
Positive_regulation (increased) of Gene_expression (expression) of epsilonPKC in lamina associated with ganglion cysts, nociception, kinase c, root ganglion neuron and spinal cord
2) Confidence 0.68 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14762097 Disease Relevance 0.45 Pain Relevance 0.61
Infusion of NMDA antagonist D-AP5 prevented both the thermal hyperalgesia and the increase in PKC gamma expression in PTX-treated rats.
Positive_regulation (increase) of Gene_expression (expression) of PKC associated with kinase c, thermal hyperalgesia and antagonist
3) Confidence 0.67 Published 2003 Journal Acta Anaesthesiol. Sin. Section Abstract Doc Link 14768516 Disease Relevance 0.90 Pain Relevance 1.99
Culturing steroidogenic cells collected from the Day -6 CL spontaneously induced the expression of PKC?
Positive_regulation (induced) of Gene_expression (expression) of PKC associated with kinase c
4) Confidence 0.67 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.20
We previously reported that the levels of metabotropic glutamate 5 (mGlu5) receptor and phosphorylated-protein kinase C (PKC) were significantly increased in the spinal cord following chronic ethanol consumption.
Positive_regulation (increased) of Gene_expression (levels) of PKC in spinal cord associated with kinase c, glutamate and spinal cord
5) Confidence 0.63 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17349994 Disease Relevance 0.41 Pain Relevance 0.64
These results show that i.t. injection of PTX induced thermal hyperalgesia accompanied by a selective increase in PKCgamma expression in both the synaptosomal membrane and cytosolic fractions of the dorsal horn of the rat lumbar spinal cord, and both effects were inhibited by the NMDA receptor antagonist, D-AP5.
Positive_regulation (increase) of Gene_expression (expression) of PKCgamma in spinal cord associated with nmda receptor antagonist, thermal hyperalgesia, dorsal horn and spinal cord
6) Confidence 0.63 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560106 Disease Relevance 0.63 Pain Relevance 0.85
Infusion of the NMDA antagonist, D-AP5, prevented both the thermal hyperalgesia and the increase in PKCgamma isoform expression in PTX-treated rats, and had no effect on these values in nai;ve rats.
Positive_regulation (increase) of Gene_expression (expression) of PKCgamma isoform associated with thermal hyperalgesia and antagonist
7) Confidence 0.63 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560106 Disease Relevance 0.76 Pain Relevance 0.94
I.t. morphine infusion, but not saline, produced a 2-fold increase in dorsal horn PKC phosphorylating activity and in the expression of PKCalpha/gamma.
Positive_regulation (increase) of Gene_expression (expression) of PKC in dorsal horn associated with kinase c, dorsal horn and morphine
8) Confidence 0.50 Published 2000 Journal Pain Section Abstract Doc Link 10781912 Disease Relevance 0 Pain Relevance 1.89
The phorbol ester and protein kinase C (PKC) activator, phorbol dibutyrate (PDBU), was observed to produce an over 100% elevation of Iscc but only a small yet significant 20-30% decrease of TER across rat distal colon.
Positive_regulation (elevation) of Gene_expression (produce) of PKC in colon associated with kinase c
9) Confidence 0.49 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539661 Disease Relevance 0 Pain Relevance 0.33
PTX-induced neuropathic pain syndrome is accompanied by increasing of EAAs, decreasing of IAA release, and a selective increasing of PKC gamma expression in the spinal cord.
Positive_regulation (increasing) of Gene_expression (expression) of PKC in spinal cord associated with kinase c, syndrome, neuropathic pain, spinal cord and excitatory amino acid
10) Confidence 0.49 Published 2003 Journal Acta Anaesthesiol. Sin. Section Abstract Doc Link 14768516 Disease Relevance 0.85 Pain Relevance 2.08
PTX-induced neuropathic pain syndrome is accompanied by increasing of EAAs, decreasing of IAA release, and a selective increasing of PKC gamma expression in the spinal cord.
Positive_regulation (increasing) of Gene_expression (expression) of PKC in spinal cord associated with kinase c, syndrome, neuropathic pain, spinal cord and excitatory amino acid
11) Confidence 0.49 Published 2003 Journal Acta Anaesthesiol. Sin. Section Abstract Doc Link 14768516 Disease Relevance 0.79 Pain Relevance 1.99
II, and there was no reduction in the amounts of these isozyme proteins even at 96 h after transfection with PKC?
Positive_regulation (transfection) of Gene_expression (transfection) of PKC associated with kinase c
12) Confidence 0.49 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.54
Additionally, there is evidence indicating that when bovine follicular theca cells are isolated and their luteinization is induced under in vitro tissue culture conditions, they express PKC?
Positive_regulation (induced) of Gene_expression (express) of PKC in theca cells associated with kinase c
13) Confidence 0.49 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.47
II, and there was no reduction in the amounts of these isozyme proteins even at 96 h after transfection with PKC?
Neg (no) Positive_regulation (after) of Gene_expression (transfection) of PKC associated with kinase c
14) Confidence 0.49 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.54
The expression of PKCmu and PKCbeta1, but not of other PKC isoforms, was also enhanced by butyrate treatment, suggesting the possibility that these two isoforms might contribute to the enhanced activity of rVR1.
Positive_regulation (enhanced) of Gene_expression (expression) of PKC
15) Confidence 0.49 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15471852 Disease Relevance 0.06 Pain Relevance 0.30
synthesis; whereas in PKC?
Positive_regulation (whereas) of Gene_expression (whereas) of PKC associated with kinase c
16) Confidence 0.49 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.46
Enriched steroidogenic cells (n = 4) transfected with PKC?
Positive_regulation (transfected) of Gene_expression (transfected) of PKC associated with kinase c
17) Confidence 0.49 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.53
PKC activity and protein expression did not change when assessed 1 h after bolus i.t. morphine in naive rats.
Neg (not) Positive_regulation (change) of Gene_expression (expression) of PKC associated with kinase c and morphine
18) Confidence 0.47 Published 2000 Journal Pain Section Abstract Doc Link 10781912 Disease Relevance 0 Pain Relevance 1.84
Coadministration of the PKC inhibitor chelerythrine (10-7M) or the O-2 scavenger polyethylene glycol superoxide dismutase and catalase (SODCAT) with NOC/oFQ (10-10M) partially prevented hypotensive pial dilation impairment (34I2 vs 28I1% for SODCAT).
Positive_regulation (Coadministration) of Gene_expression (Coadministration) of PKC
19) Confidence 0.43 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 11782666 Disease Relevance 0.17 Pain Relevance 0
In our previous studies, we found that intrathecal (i.t.) injection of pertussis toxin (PTX) produces thermal hyperalgesia, which is poorly responsive to morphine and is accompanied by an increase in cerebrospinal fluid (CSF) levels of excitatory amino acids (EAAs) and protein kinase C (PKC) activation.
Positive_regulation (increase) of Gene_expression (levels) of PKC in CSF associated with kinase c, bordatella infection, thermal hyperalgesia, excitatory amino acid, morphine and intrathecal
20) Confidence 0.43 Published 2006 Journal Life Sci. Section Abstract Doc Link 16271370 Disease Relevance 0.45 Pain Relevance 1.22

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