INT517

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Context Info
Confidence 0.62
First Reported 1979
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 16
Total Number 19
Disease Relevance 5.43
Pain Relevance 6.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) cell proliferation (Mif) extracellular space (Mif)
aging (Mif) extracellular region (Mif) nucleus (Mif)
Anatomy Link Frequency
blood 3
ganglion 2
plasma 1
liver 1
smooth muscle 1
Mif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 51 100.00 Very High Very High Very High
Pain 10 100.00 Very High Very High Very High
Opioid 5 100.00 Very High Very High Very High
dorsal root ganglion 14 99.22 Very High Very High Very High
Spinal cord 70 98.68 Very High Very High Very High
Inflammation 186 98.64 Very High Very High Very High
tolerance 6 98.36 Very High Very High Very High
Hyperalgesia 10 98.20 Very High Very High Very High
analgesia 7 97.28 Very High Very High Very High
opiate 3 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 20 100.00 Very High Very High Very High
Malignant Neoplastic Disease 17 100.00 Very High Very High Very High
Ganglion Cysts 22 99.78 Very High Very High Very High
Cystitis 44 99.68 Very High Very High Very High
Injury 48 99.04 Very High Very High Very High
INFLAMMATION 189 98.64 Very High Very High Very High
Hyperalgesia 10 98.20 Very High Very High Very High
Nociception 2 96.76 Very High Very High Very High
Cancer 58 96.24 Very High Very High Very High
Inflammatory Pain 2 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test this hypothesis, we observed changes in MIF, cyclooxygenase-2 (COX-2) and c-fos in the bladder, L6-S1 spinal cord, dorsal root ganglion (DRG), and major pelvic ganglion (MPG) and MIF changes in the prostate following intravesical LPS.
Regulation (changes) of MIF in ganglion associated with ganglion cysts, dorsal root ganglion and spinal cord
1) Confidence 0.62 Published 2004 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 14980085 Disease Relevance 0.51 Pain Relevance 0.32
Experiment 2 was designed to investigate the possible synergistic effect of MIF-I and melatonin.
Spec (possible) Regulation (effect) of MIF-I
2) Confidence 0.60 Published 1982 Journal Peptides Section Abstract Doc Link 6126866 Disease Relevance 0 Pain Relevance 1.30
In addition, there were changes in the levels of MIF and cyclooxygenase-2 in the central and peripheral nervous tissues that innervate the bladder and other pelvic viscera.
Regulation (changes) of MIF in bladder
3) Confidence 0.45 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.46 Pain Relevance 0.36
To test this hypothesis, we observed changes in MIF, cyclooxygenase-2 (COX-2) and c-fos in the bladder, L6-S1 spinal cord, dorsal root ganglion (DRG), and major pelvic ganglion (MPG) and MIF changes in the prostate following intravesical LPS.
Regulation (changes) of MIF in ganglion associated with ganglion cysts, dorsal root ganglion and spinal cord
4) Confidence 0.45 Published 2004 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 14980085 Disease Relevance 0.54 Pain Relevance 0.34
The effects of MIF-I (Pro-Leu-Gly-NH2) were examined in three experimental conditions in which the opiate antagonist naloxone is active.
Regulation (effects) of MIF-I associated with antagonist, narcan and opiate
5) Confidence 0.44 Published 1979 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 43981 Disease Relevance 0 Pain Relevance 0.75
The effects of several analogs of melanotropin-release inhibiting factor (MIF, Pro-Leu-Gly-NH2) on the development of tolerance to the hyperthermic, hypothermic and cataleptic actions of morphine were investigated in male Sprague-Dawley rats.
Spec (investigated) Regulation (effects) of MIF associated with tolerance and morphine
6) Confidence 0.38 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6128692 Disease Relevance 0 Pain Relevance 0.48
As macrophage migration inhibitory factor (MIF), a pleiotropic cytokine produced mainly by nonneuronal tissue, has been involved in the regulation of neuronal functions, herein we examined the role for MIF in formalin-induced inflammatory pain model.
Regulation (produced) of MIF in neuronal associated with ipn and cytokine
7) Confidence 0.38 Published 2010 Journal Pain Section Abstract Doc Link 20005040 Disease Relevance 0.62 Pain Relevance 0.51
Therefore, our present results represent changes in tissue levels (or release) of MIF without the confounding presence of blood/serum MIF in the bladder or urine.


Regulation (changes) of MIF in urine
8) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.28 Pain Relevance 0.07
These data continue to support our hypothesis that MIF is a new target for intervention in pelvic viscera inflammation.


Regulation (target) of MIF in viscera
9) Confidence 0.27 Published 2004 Journal J. Urol. Section Body Doc Link 15371880 Disease Relevance 0.10 Pain Relevance 0
SP induced changes in MIF, cyclooxygenase-2, nerve growth factor, c-fos and edema were decreased by intraluminal anti-MIF.
Regulation (changes) of MIF in nerve
10) Confidence 0.27 Published 2004 Journal J. Urol. Section Body Doc Link 15371880 Disease Relevance 0.15 Pain Relevance 0
Finally, MIF immunoreactivity was also observed in the smooth muscle in the bladder, confirming our previous findings.
Regulation (immunoreactivity) of MIF in smooth muscle
11) Confidence 0.27 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0 Pain Relevance 0.07
In contrast, CA 125 and MIF were not affected by the conditions of blood collection; both markers discriminated between cases and controls irrespective of whether serum specimens were collected at surgery or in a short interval prior to surgery.
Neg (not) Regulation (not) of MIF in blood
12) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2093996 Disease Relevance 0.27 Pain Relevance 0.22
MIF immunoreactivity was observed over most of the neurons in the L6/S1 DRG of rats of either sex.
Regulation (immunoreactivity) of MIF in neurons
13) Confidence 0.24 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.08 Pain Relevance 0.04
Such associations, if present, would indicate another possible receptor target for MIF during cystitis, aside from the already described MIF-CD74 association [15].
Spec (possible) Regulation (target) of MIF associated with cystitis
14) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.64 Pain Relevance 0.28
Finally, while endotoxin can elicit MIF release it also results in MIF down-regulation [26], [33] which is opposite to the effect of up-regulation seen in our studies.
Regulation (regulation) of MIF
15) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0
Furthermore, HMGB1and MIF are more sensitive than liver enzymes to detect the additional mechanical damage inflicted on the organ graft during surgical manipulation.


1.

Regulation (sensitive) of MIF in liver
16) Confidence 0.18 Published 2010 Journal Mediators of Inflammation Section Abstract Doc Link PMC3010695 Disease Relevance 0.62 Pain Relevance 0.14
Gender-related effects of chronic non-malignant pain and opioid therapy on plasma levels of macrophage migration inhibitory factor (MIF).
Regulation (effects) of migration inhibitory factor in plasma associated with pain, malignant neoplastic disease and opioid
17) Confidence 0.13 Published 2005 Journal Pain Section Title Doc Link 15836977 Disease Relevance 0.85 Pain Relevance 1.43
In contrast, CA 125 and MIF were not affected by the conditions of blood collection; both markers discriminated between cases and controls irrespective of whether serum specimens were collected at surgery or in a short interval prior to surgery.
Neg (not) Regulation (affected) of MIF in blood
18) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2093996 Disease Relevance 0.27 Pain Relevance 0.22
In the regression models, CA 125 and MIF concentrations were not significantly affected by the conditions of blood collection (table 2, p?
Neg (not) Regulation (affected) of MIF in blood
19) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2093996 Disease Relevance 0.05 Pain Relevance 0

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