INT51722

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Context Info
Confidence 0.05
First Reported 1995
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.37
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (HELLS) nucleus (HELLS) helicase activity (HELLS)
cell cycle (HELLS) DNA binding (HELLS) cell division (HELLS)
Anatomy Link Frequency
neuronal 2
HELLS (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 1 100.00 Very High Very High Very High
nMDA receptor 5 99.98 Very High Very High Very High
Abstinence syndrome 2 96.84 Very High Very High Very High
Dextromethorphan 5 96.08 Very High Very High Very High
opiate 2 90.00 High High
addiction 1 88.92 High High
withdrawal 1 38.00 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 2 96.40 Very High Very High Very High
Death 1 94.56 High High
Opiate Addiction 2 88.92 High High
Nicotine Addiction 1 25.00 Low Low
Diarrhoea 1 25.00 Low Low
Sleep Disorders 1 25.00 Low Low
Akathisia 1 25.00 Low Low
Vomiting 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the stimulation of NMDA receptors modulates the release of neurotransmitters and hormones such as NE, D, ACh, GH, LH, LSH, ACTH etc., all of which have been found responsible for the manifestation of abstinence syndrome signs including craving and neuronal death by excessive stimulation of NMDA receptors, the incomplete blockade of the NMDA receptors minimizes the intensity of the abstinence syndrome and provides the downregulation of the receptors.
Positive_regulation (modulates) of Localization (release) of LSH in neuronal associated with neurotransmitter, syndrome, nmda receptor, death and abstinence syndrome
1) Confidence 0.05 Published 1995 Journal Int J Clin Pharmacol Ther Section Abstract Doc Link 7711985 Disease Relevance 0.37 Pain Relevance 0.76

General Comments

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