INT51722

Context Info Confidence 0.05 First Reported 1995 Last Reported 1995 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.37 Pain Relevance 0.76

mitosis (HELLS) nucleus (HELLS) helicase activity (HELLS) cell cycle (HELLS) DNA binding (HELLS) cell division (HELLS)

Anatomy Link Frequency neuronal 2 HELLS (Homo sapiens)

Pain Link Frequency Relevance Heat Neurotransmitter 1 100.00 nMDA receptor 5 99.98 Abstinence syndrome 2 96.84 Dextromethorphan 5 96.08 opiate 2 90.00 addiction 1 88.92 withdrawal 1 38.00

Disease Link Frequency Relevance Heat Syndrome 2 96.40 Death 1 94.56 Opiate Addiction 2 88.92 Nicotine Addiction 1 25.00 Diarrhoea 1 25.00 Sleep Disorders 1 25.00 Akathisia 1 25.00 Vomiting 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As the stimulation of NMDA receptors modulates the release of neurotransmitters and hormones such as NE, D, ACh, GH, LH, LSH, ACTH etc., all of which have been found responsible for the manifestation of abstinence syndrome signs including craving and neuronal death by excessive stimulation of NMDA receptors, the incomplete blockade of the NMDA receptors minimizes the intensity of the abstinence syndrome and provides the downregulation of the receptors.

Positive_regulation (modulates) of Localization (release) of LSH in neuronal associated with neurotransmitter, syndrome, nmda receptor, death and abstinence syndrome

1) Confidence 0.05 Published 1995 Journal Int J Clin Pharmacol Ther Section Abstract Doc Link 7711985 Disease Relevance 0.37 Pain Relevance 0.76

General Comments

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