INT51728

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Context Info
Confidence 0.42
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.85
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cytoplasm (Tyr)
Anatomy Link Frequency
vesicles 1
Tyr (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 98.44 Very High Very High Very High
agonist 6 95.28 Very High Very High Very High
antagonist 3 95.04 Very High Very High Very High
sodium channel 3 75.00 Quite High
melanocortin 1 receptor 3 75.00 Quite High
Nav1.6 1 75.00 Quite High
Inflammation 2 67.36 Quite High
tetrodotoxin 1 59.08 Quite High
dorsal root ganglion 1 42.16 Quite Low
Neuronal excitability 1 28.32 Quite Low
Disease Link Frequency Relevance Heat
Hypopigmentation 2 100.00 Very High Very High Very High
Skin Cancer 3 98.76 Very High Very High Very High
Stress 4 97.68 Very High Very High Very High
INFLAMMATION 5 71.76 Quite High
Adhesions 5 56.64 Quite High
Ganglion Cysts 1 42.16 Quite Low
Disease 63 30.44 Quite Low
Targeted Disruption 11 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 6 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A multivariate analysis of repeated measures: linkage of the albinism gene (Tyr) to a QTL influencing ethanol-induced anesthesia in laboratory mice.
Tyr Binding (linkage) of associated with anesthesia and hypopigmentation
1) Confidence 0.42 Published 1994 Journal Psychiatr. Genet. Section Title Doc Link 7712116 Disease Relevance 0.18 Pain Relevance 0.18
Antagonist and agonist activities of chemically synthetized mouse agouti protein fragment (91-131) (AP91-131) at the melanocortin type-1 receptor (MC1-R) were assessed using B 16-F1 mouse melanoma cells in vitro and the following assay systems: (i) receptor binding, (ii) adenylate cyclase, (iii) tyrosinase, (iv) melanin production, and (v) cell proliferation.
tyrosinase Binding (binding) of associated with antagonist, agonist and skin cancer
2) Confidence 0.15 Published 2001 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 11693171 Disease Relevance 0.10 Pain Relevance 0.32
The data indicate that HS401 (Ac-Tyr-Lys-Pro-Val-NH2) and HS402 (Ac-Lys-Pro-Val-Tyr-NH2) selectively bound to the MC1 receptor and stimulated cAMP generation in a concentration dependent way while the other Tyr- and Trp-containing alpha-MSH11-13 analogues neither bound to MC receptors nor stimulated cAMP.
Tyr Binding (bound) of
3) Confidence 0.07 Published 2006 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 17040213 Disease Relevance 0.16 Pain Relevance 0.11
The data indicate that HS401 (Ac-Tyr-Lys-Pro-Val-NH2) and HS402 (Ac-Lys-Pro-Val-Tyr-NH2) selectively bound to the MC1 receptor and stimulated cAMP generation in a concentration dependent way while the other Tyr- and Trp-containing alpha-MSH11-13 analogues neither bound to MC receptors nor stimulated cAMP.
Tyr Binding (bound) of
4) Confidence 0.07 Published 2006 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 17040213 Disease Relevance 0.16 Pain Relevance 0.11
Indeed, a recent study demonstrated that PS deficiency resulted in mislocalization of post-Golgi tyrosinase-containing vesicles; and such an abnormal trafficking of tyrosinase is ?
tyrosinase Binding (trafficking) of in vesicles
5) Confidence 0.04 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.06 Pain Relevance 0
Thus, phosphorylation of the Pro-Gly-Ser-Pro motif within L1 of Na(v)1.6 is necessary for stress-induced current modulation, with positive or negative regulation depending upon the availability of the C-terminal Pro-Ser-Tyr motif to bind Nedd4-2.
Pro-Ser-Tyr motif Binding (bind) of associated with stress
6) Confidence 0.03 Published 2010 Journal J. Biol. Chem. Section Abstract Doc Link 20530479 Disease Relevance 0.19 Pain Relevance 0.17

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