INT51739

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Context Info
Confidence 0.42
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.21
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apob) extracellular space (Apob) endoplasmic reticulum (Apob)
enzyme binding (Apob) lipid metabolic process (Apob)
Apob (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 261 96.64 Very High Very High Very High
Inflammation 42 92.76 High High
rheumatoid arthritis 2 50.00 Quite Low
Chronic pancreatitis 1 50.00 Quite Low
Inflammatory response 1 6.52 Low Low
cytokine 14 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 44 100.00 Very High Very High Very High
Hyperlipoproteinemia Type Ii 113 98.28 Very High Very High Very High
Hyperlipidemia 41 97.84 Very High Very High Very High
Hepatotoxicity 198 93.16 High High
INFLAMMATION 41 92.76 High High
Apoptosis 101 87.20 High High
Cardiovascular Disease 42 87.16 High High
Injury 16 85.88 High High
Obesity 1 85.68 High High
Disease 39 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Total cholesterol, LDL cholesterol and apolipoprotein B were lower in the pancreatitis patients (p < 0.01); 92% of these were smokers vs 62% of idiopathic diabetes patients (p < 0.001).
Negative_regulation (lower) of apolipoprotein B
1) Confidence 0.42 Published 1994 Journal Diabete Metab Section Body Doc Link 7713277 Disease Relevance 0.12 Pain Relevance 0
We have previously published data demonstrating specific reduction of mouse ApoB (19) and PTEN (18) mRNA in mice treated with 20mer MOE ASOs.
Negative_regulation (reduction) of ApoB
2) Confidence 0.25 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.51 Pain Relevance 0.13
Doses as low as 100 mg per week produced statistically significant reductions in ApoB protein, and a dose of 200 mg per week reduced serum ApoB protein by 50% (20).
Negative_regulation (reductions) of ApoB protein
3) Confidence 0.18 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.09 Pain Relevance 0.08
Doses as low as 100 mg per week produced statistically significant reductions in ApoB protein, and a dose of 200 mg per week reduced serum ApoB protein by 50% (20).
Negative_regulation (reduced) of ApoB protein
4) Confidence 0.18 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.08 Pain Relevance 0.08
The 5-10-5 MOE ASO 6 produced a modest 24% inhibition of ApoB mRNA at the 0.4 ?
Negative_regulation (inhibition) of ApoB
5) Confidence 0.18 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.45 Pain Relevance 0.19
50% reduction in ApoB-100 mRNA at the 2.5 ?
Negative_regulation (reduction) of ApoB-100 mRNA
6) Confidence 0.18 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.37 Pain Relevance 0.19
In summary, the above studies in patients with primary HC (predominantly non-FH) showed that ezetimibe monotherapy or ezetimibe combined with a statin significantly reduces TC, LDL-C, apoB, and TG and increases HDL-C levels compared with placebo.
Negative_regulation (reduces) of apoB associated with hyperlipoproteinemia type ii, hyperlipidemia and disorder of lipid metabolism
7) Confidence 0.12 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.83 Pain Relevance 0
Down-regulation of apoB-100 by continues intravenous/subcutaneous administration of Mipomersen antisense apolipoprotein B-100 oligonucleotide had been attempted in several clinical trials achieving average LDL-C reduction of 36-37%.
Negative_regulation (regulation) of apoB associated with disorder of lipid metabolism
8) Confidence 0.09 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.36 Pain Relevance 0
When IL-6 was administrated to normal healthy volunteers [94], within 24 h of IL-6 administration, total cholesterol, apolipoprotein B and triglyceride were reduced.
Negative_regulation (reduced) of apolipoprotein B associated with disorder of lipid metabolism
9) Confidence 0.03 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 1.32 Pain Relevance 0.12

General Comments

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