INT51741

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Context Info
Confidence 0.36
First Reported 1993
Last Reported 2011
Negated 11
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 12.70
Pain Relevance 7.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
T cells 6
B cells 2
brains 2
ganglia 2
lung 2
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 526 100.00 Very High Very High Very High
cytokine 502 100.00 Very High Very High Very High
Opioid 13 100.00 Very High Very High Very High
Morphine 14 98.52 Very High Very High Very High
opioid receptor 8 96.80 Very High Very High Very High
methadone 5 95.56 Very High Very High Very High
Inflammatory response 31 94.56 High High
fibrosis 239 90.44 High High
antagonist 7 88.72 High High
narcan 4 87.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 516 100.00 Very High Very High Very High
Infection 217 99.28 Very High Very High Very High
Fibrosis 199 99.16 Very High Very High Very High
Necrosis 18 98.52 Very High Very High Very High
Cold Sores 367 98.32 Very High Very High Very High
Cancer 437 98.16 Very High Very High Very High
Targeted Disruption 62 98.12 Very High Very High Very High
Immunization 15 97.84 Very High Very High Very High
Sprains And Strains 75 97.12 Very High Very High Very High
Rheumatoid Arthritis 96 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Production of interleukin (IL)-2, IL-4, and IL-6 was affected only moderately by all drugs except morphine-6-glucuronide, which produced a marked suppression at 100 mumol/l.
Regulation (affected) of Gene_expression (Production) of IL-4 associated with morphine
1) Confidence 0.36 Published 1995 Journal Pharmacology Section Abstract Doc Link 7899480 Disease Relevance 0 Pain Relevance 1.00
Since this effect was not found with purified B cells and no enhancement of IL-4 receptor expression on B cells could be observed, we studied the effect of beta-End on IL-4 production.
Regulation (effect) of Gene_expression (production) of IL-4 in B cells
2) Confidence 0.34 Published 1993 Journal Cell. Immunol. Section Abstract Doc Link 8099850 Disease Relevance 0 Pain Relevance 0.09
Experiments undertaken to reveal the mechanism of action of opioid peptides suggest an overall enhancement of lymphokine production: (1) enhancement of IL-4 production occurred also in the presence of excess IL-2; and (2) neither IL-1 receptor-antagonizing protein nor anti-IL-6 were capable to abrogate the stimulatory effect on IL-2 and IL-4 production.
Regulation (effect) of Gene_expression (production) of IL-4 associated with opioid
3) Confidence 0.28 Published 1994 Journal Cell. Immunol. Section Abstract Doc Link 7907006 Disease Relevance 0 Pain Relevance 0.70
In contrast, IL-4 production was only affected at the 100 microM concentration of both drugs.
Regulation (affected) of Gene_expression (production) of IL-4
4) Confidence 0.28 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7713351 Disease Relevance 0.06 Pain Relevance 0.39
To this end, the effects of various opioid peptides on the production of IL-2, IL-4, IL-6, and interferon-gamma (IFN-gamma) by CD4+ T cells were determined.
Regulation (effects) of Gene_expression (production) of IL-4 in T cells associated with opioid
5) Confidence 0.25 Published 1994 Journal Lymphokine Cytokine Res. Section Abstract Doc Link 7914752 Disease Relevance 0 Pain Relevance 0.39
Our KLH experiments indicate that Bv8 affects a number of temporal steps in immune activation: the in vivo experiments showed that it significantly modulates IL-4 and IL-10 production regardless of whether it is given at the time of KLH immunisation or four hours before in vitro KLH restimulation.
Spec (whether) Regulation (modulates) of Gene_expression (production) of IL-4 associated with immunization
6) Confidence 0.23 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.16 Pain Relevance 0.20
A second infestation administered 14 days after a primary exposure to ticks resulted in partially reduced CFSE dilution with no change in IL-4 expression when compared to one exposure to ticks.
Neg (no) Regulation (change) of Gene_expression (expression) of IL-4
7) Confidence 0.22 Published 2009 Journal Parasit Vectors Section Abstract Doc Link PMC2764639 Disease Relevance 0.27 Pain Relevance 0.07
The IL-4 levels for the BALB/cA control groups were relatively low compared to levels in NIH mice.
Regulation (control) of Gene_expression (levels) of IL-4
8) Confidence 0.21 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.14 Pain Relevance 0.19
Altogether, despite a clear cut influence on IL-4 levels, to what extent CERK may participate in TH2 cell biology remains elusive.
Regulation (influence) of Gene_expression (levels) of IL-4
9) Confidence 0.21 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.16 Pain Relevance 0.12
Although interleukin-4 production was not affected by motapizone or decreased by rolipram, circulating levels of interleukin-10, however, were significantly increased in PDE inhibitor-treated mice compared with controls.
Neg (not) Regulation (affected) of Gene_expression (production) of interleukin-4
10) Confidence 0.18 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8996181 Disease Relevance 0.69 Pain Relevance 0.11
In contrast, the production of IL-4, IL-5, and IL-13 by in vitro-activated established human Th2 effector cells was only moderately affected by p38 MAPK inhibition, suggesting that additional pathways mediate the expression of these cytokines in effector Th2 cells in comparison with primary T cells [60].
Regulation (affected) of Gene_expression (production) of IL-4 in T cells associated with cytokine
11) Confidence 0.18 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.08 Pain Relevance 0.13
The production of IL-2 and IL-4 was not significantly different from the non-treated control levels.


Neg (not) Regulation (different) of Gene_expression (production) of IL-4
12) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001867 Disease Relevance 1.34 Pain Relevance 0.08
production; but in our model, IL-4 production on
Regulation (on) of Gene_expression (production) of IL-4
13) Confidence 0.13 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233982 Disease Relevance 0.38 Pain Relevance 0.19
production; but in our model, IL-4 production on
Regulation (but) of Gene_expression (production) of IL-4
14) Confidence 0.13 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233982 Disease Relevance 0.38 Pain Relevance 0.20
Neither IL-4, in Th2 polarization, nor IL-6, TGF-?
Neg (nor) Regulation (nor) of Gene_expression (polarization) of IL-4
15) Confidence 0.13 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.11 Pain Relevance 0.06
No similar effect on the levels of IL-4, IL-13 or IFN-?
Neg (No) Regulation (effect) of Gene_expression (levels) of IL-4
16) Confidence 0.12 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 0.35 Pain Relevance 0.28
No similar effect on the levels of IL-4, IL-13 or IFN-?
Neg (No) Regulation (effect) of Gene_expression (levels) of IL-4
17) Confidence 0.12 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 0.96 Pain Relevance 0.39
No similar effect on the levels of IL-4, IL-13 or IFN-?
Neg (No) Regulation (effect) of Gene_expression (levels) of IL-4
18) Confidence 0.12 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 1.57 Pain Relevance 0.34
No significant change in the production of IL-4 and IL-10 was observed in the brains of these transgenic mice compared to their respective controls, indicating the absence of an anti-inflammatory response.
Neg (No) Regulation (change) of Gene_expression (production) of IL-4 in brains associated with targeted disruption and inflammatory response
19) Confidence 0.09 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC555557 Disease Relevance 0.91 Pain Relevance 0.59
No significant effect of the anti-inflammatory treatments was observed on lung inflammatory parameters as well as cytokine production (IL-10, IL-4, IL-13 and IFN-?)
Neg (No) Regulation (effect) of Gene_expression (production) of IL-4 in lung associated with inflammation and cytokine
20) Confidence 0.09 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 1.51 Pain Relevance 0.88

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