INT51743

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Context Info
Confidence 0.76
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.30
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Uts2) extracellular region (Uts2)
Anatomy Link Frequency
cardiovascular system 1
smooth muscle 1
muscle 1
truncus arteriosus 1
Uts2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 1 99.68 Very High Very High Very High
ischemia 4 75.00 Quite High
tetrodotoxin 4 73.68 Quite High
Somatostatin 3 69.52 Quite High
Catecholamine 1 58.48 Quite High
Intracerebroventricular 1 29.28 Quite Low
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hypertension 2 92.32 High High
Cv Unclassified Under Development 2 75.00 Quite High
Cv General 4 Under Development 2 68.00 Quite High
Infarction 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dogfish urotensin II produced a dose-dependent contraction (pD2 = 6.58 +/- 0.07; n = 8) of isolated rings of vascular muscle prepared from the first afferent branchial artery of the dogfish.
Gene_expression (produced) of urotensin II in muscle
1) Confidence 0.76 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8214148 Disease Relevance 0.16 Pain Relevance 0.10
The ileal smooth muscle strips exhibited only weak spontaneous contractions but frog urotensin II produced concentration-dependent increases in both the frequency (EC50 = 1.3 x 10(-9) M) and the strength (EC50 = 3.6 x 10(-9) M) of contraction.
Gene_expression (produced) of urotensin II in smooth muscle
2) Confidence 0.65 Published 1994 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 7883148 Disease Relevance 0 Pain Relevance 0.11
Frog urotensin II produced a concentration-dependent increase in the frequency of contraction (EC50 = 8.1 x 10(-9) M) but had no significant effect on tension.
Gene_expression (produced) of urotensin II
3) Confidence 0.65 Published 1994 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 7883148 Disease Relevance 0 Pain Relevance 0
Bolus injections of frog urotensin II (100 nmol/kg) into the left systemic arch produced a rapid and sustained fall in blood flow through the right branch of the truncus arteriosus (to 62 +/- 5% of preinjection values; n = 8).
Gene_expression (produced) of urotensin II in truncus arteriosus
4) Confidence 0.61 Published 1995 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 7713374 Disease Relevance 0 Pain Relevance 0
U-II and its receptor are expressed in the central nervous system, in the cardiovascular system and in other peripheral tissues.
Gene_expression (expressed) of U-II in cardiovascular system associated with central nervous system
5) Confidence 0.53 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18191840 Disease Relevance 0.14 Pain Relevance 0.12

General Comments

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