INT51744

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Context Info
Confidence 0.56
First Reported 1994
Last Reported 2008
Negated 4
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 0.23
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Uts2) extracellular region (Uts2)
Anatomy Link Frequency
smooth muscle 2
sinus 2
blood 1
ileum 1
bladder 1
Uts2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 4 100.00 Very High Very High Very High
ischemia 4 98.88 Very High Very High Very High
tetrodotoxin 5 98.16 Very High Very High Very High
Somatostatin 5 97.44 Very High Very High Very High
Central nervous system 1 91.88 High High
Intracerebroventricular 1 56.84 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 2 98.88 Very High Very High Very High
Cv General 4 Under Development 2 76.20 Quite High
Infarction 1 43.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The contractile effect of urotensin II (10(-7) M) was not affected by preincubation of the rings with atropine, tetrodotoxin, and somatostatin-14 but indomethacin produced a significant (P < 0.05) decrease in the amplitude of the contractions of the systemic arch (to 18 +/- 2% of control values; n = 6).
Neg (not) Regulation (affected) of urotensin II associated with tetrodotoxin and somatostatin
1) Confidence 0.56 Published 1995 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 7713374 Disease Relevance 0 Pain Relevance 0.15
AIM: To study the effects of urotensin II (UII) on the carotid sinus baroreflex (CSB).
Regulation (effects) of UII in sinus
2) Confidence 0.45 Published 2007 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 17241524 Disease Relevance 0 Pain Relevance 0
AIM: To study the effects of urotensin II (UII) on the carotid sinus baroreflex (CSB).
Regulation (effects) of urotensin II in sinus
3) Confidence 0.45 Published 2007 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 17241524 Disease Relevance 0 Pain Relevance 0
The data suggest an involvement of prostaglandin synthesis in the contractile action of urotensin II on isolated frog vascular smooth muscle but, unlike in mammals, urotensin II does not stimulate nitric oxide synthesis in this tissue.
Regulation (involvement) of urotensin II in smooth muscle
4) Confidence 0.41 Published 1995 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 7713374 Disease Relevance 0 Pain Relevance 0.13
The effects of synthetic frog urotensin II on cardiac output and arterial blood pressure and on the motility of isolated vascular smooth muscle were investigated in the bullfrog, Rana catesbeiana.
Spec (investigated) Regulation (effects) of urotensin II in smooth muscle
5) Confidence 0.41 Published 1995 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 7713374 Disease Relevance 0 Pain Relevance 0
Effects of urotensin-II on cerebral blood flow and ischemia in anesthetized rats.
Regulation (Effects) of urotensin-II in blood associated with anesthesia and ischemia
6) Confidence 0.40 Published 2008 Journal Exp. Neurol. Section Title Doc Link 18191840 Disease Relevance 0.23 Pain Relevance 0.29
In both the frog bladder and ileum preparations, the effect of urotensin II was not affected by preincubation of the strips with atropine, tetrodotoxin, and somatostatin-14 but indomethacin produced a significant (P < 0.05) decrease in the strength of the contractions of the bladder (to 21 +/- 6% of control values) and ileum (to 32 +/- 13%).
Neg (not) Regulation (affected) of urotensin II in ileum associated with tetrodotoxin and somatostatin
7) Confidence 0.26 Published 1994 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 7883148 Disease Relevance 0 Pain Relevance 0.15
Pretreatment with NG-nitro-L-arginine methyl ester (L-NAME) 100 micromol/L did not affect the inhibitory effects of UII (300 nmol/L) on the CSB.
Neg (not) Regulation (affect) of UII
8) Confidence 0.24 Published 2007 Journal Acta Pharmacol. Sin. Section Body Doc Link 17241524 Disease Relevance 0 Pain Relevance 0
In both the frog bladder and ileum preparations, the effect of urotensin II was not affected by preincubation of the strips with atropine, tetrodotoxin, and somatostatin-14 but indomethacin produced a significant (P < 0.05) decrease in the strength of the contractions of the bladder (to 21 +/- 6% of control values) and ileum (to 32 +/- 13%).
Neg (not) Regulation (affected) of urotensin II in bladder associated with tetrodotoxin and somatostatin
9) Confidence 0.09 Published 1994 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 7883148 Disease Relevance 0 Pain Relevance 0.15

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