INT51747

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Context Info
Confidence 0.65
First Reported 1993
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 0.22
Pain Relevance 3.06

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Anatomy Link Frequency
neurons 3
gland 1
RMRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 17 99.82 Very High Very High Very High
Dopamine 21 99.48 Very High Very High Very High
Neuropeptide 1 99.44 Very High Very High Very High
Opioid 8 98.28 Very High Very High Very High
antagonist 4 95.40 Very High Very High Very High
narcan 10 94.08 High High
medulla 3 92.76 High High
Disease Link Frequency Relevance Heat
Hypoglycemia 3 80.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This provides the first evidence for direct inputs from enkephalinergic neurons into dendrites of both CHH cell types, which suggests that enkephalins inhibit release of both CHH isoforms via synaptic contacts.
Localization (release) of CHH in neurons associated with enkephalin
1) Confidence 0.65 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11835178 Disease Relevance 0 Pain Relevance 0.36
Previous reports have demonstrated that release of CHH from the sinus gland is inhibited by enkephalins.
Localization (release) of CHH in gland associated with enkephalin
2) Confidence 0.57 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11835178 Disease Relevance 0 Pain Relevance 0.16
In vitro incubations of neurosecretory complexes followed by immunoassays of CHH isoforms indicated that both methionine and leucine enkephalins inhibit release of the two CHH isoforms from crayfish eyestalks, by a receptor mediated process.
Localization (release) of CHH associated with enkephalin
3) Confidence 0.57 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11835178 Disease Relevance 0 Pain Relevance 0.35
Double labelling experiments were performed on the same tissue section at the electron microscopic level, in order to show the involvement of the opioid leucine-enkephalin (Leu-enk) in the modulation of crustacean hyperglycaemic hormone (CHH) mobilization.
Localization (mobilization) of CHH associated with enkephalin and opioid
4) Confidence 0.42 Published 1993 Journal Histochemistry Section Abstract Doc Link 8392990 Disease Relevance 0 Pain Relevance 0.57
In vitro, both DA and L-Enk reduced the rate of release of the crustacean hyperglycemic hormone (CHH) from isolated eyestalk neuroendocrine tissue.
Localization (release) of CHH associated with dopamine
5) Confidence 0.06 Published 1995 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 7713380 Disease Relevance 0.08 Pain Relevance 0.58
These results suggest that both DA and L-Enk act to inhibit release of CHH by affecting the eyestalk neuroendocrine complex and that the enkephalinergic inhibitory neuron follows the dopaminergic inhibitory neuron in the chain of neurons which leads to the neuroendocrine cells that secrete CHH.
Localization (secrete) of CHH in neurons associated with dopamine
6) Confidence 0.04 Published 1995 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 7713380 Disease Relevance 0.07 Pain Relevance 0.49
These results suggest that both DA and L-Enk act to inhibit release of CHH by affecting the eyestalk neuroendocrine complex and that the enkephalinergic inhibitory neuron follows the dopaminergic inhibitory neuron in the chain of neurons which leads to the neuroendocrine cells that secrete CHH.
Localization (release) of CHH in neurons associated with dopamine
7) Confidence 0.04 Published 1995 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 7713380 Disease Relevance 0.07 Pain Relevance 0.55

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