INT51777

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2006
Negated 0
Speculated 1
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 2.91
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Akr1b1) oxidoreductase activity (Akr1b1) nucleolus (Akr1b1)
nucleus (Akr1b1) cytoplasm (Akr1b1)
Anatomy Link Frequency
neuronal 2
nerve 2
Akr1b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 3 99.80 Very High Very High Very High
Hyperalgesia 2 99.32 Very High Very High Very High
Brush evoked pain 7 98.80 Very High Very High Very High
Inflammation 4 96.80 Very High Very High Very High
cINOD 1 95.36 Very High Very High Very High
allodynia 3 95.00 High High
Neuropathic pain 1 75.00 Quite High
Sciatic nerve 1 55.80 Quite High
Painful diabetic neuropathy 1 44.08 Quite Low
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 18 99.86 Very High Very High Very High
Pressure And Volume Under Development 1 99.68 Very High Very High Very High
Hyperalgesia 2 99.32 Very High Very High Very High
Neuropathic Pain 12 98.80 Very High Very High Very High
INFLAMMATION 5 96.80 Very High Very High Very High
Diabetes Complications 1 92.48 High High
Nervous System Injury 1 63.20 Quite High
Experimental Diabetes Mellitus 1 62.36 Quite High
Hyperglycemia 1 50.88 Quite High
Diabetic Neuropathy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of the aldose reductase enzyme was found to depend on the presence of both the benzoyl and acetic acid functionalities.
Regulation (depend) of Negative_regulation (Inhibition) of aldose reductase
1) Confidence 0.45 Published 1995 Journal J Pharm Sci Section Abstract Doc Link 7714750 Disease Relevance 0.45 Pain Relevance 0.25
Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine.
Regulation (effects) of Negative_regulation (inhibition) of aldose reductase associated with brush evoked pain, hyperalgesia, diabetes mellitus and lidocaine
2) Confidence 0.39 Published 1996 Journal Pain Section Title Doc Link 9121817 Disease Relevance 1.76 Pain Relevance 1.12
Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats.
Regulation (effects) of Negative_regulation (inhibitors) of aldose reductase in nerve associated with diabetes mellitus
3) Confidence 0.31 Published 1997 Journal Diabetologia Section Title Doc Link 9084964 Disease Relevance 0.47 Pain Relevance 0.03
We also sought to determine which neuronal phenotypes are affected and to examine the effect of aldose reductase inhibition on JNK and c-Jun phosphorylation.
Spec (examine) Regulation (effect) of Spec (examine) Negative_regulation (inhibition) of aldose reductase in neuronal
4) Confidence 0.29 Published 2006 Journal Diabetologia Section Abstract Doc Link 16456679 Disease Relevance 0.24 Pain Relevance 0.07

General Comments

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