INT51779

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Context Info
Confidence 0.66
First Reported 1995
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 46
Total Number 46
Disease Relevance 11.18
Pain Relevance 17.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd1a) endoplasmic reticulum (Drd1a) plasma membrane (Drd1a)
nucleus (Drd1a) intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
neurons 20
striatum 5
shell 2
substantia nigra pars reticulata 1
globus pallidus 1
Drd1a (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 1229 100.00 Very High Very High Very High
Nucleus accumbens 213 100.00 Very High Very High Very High
dopamine receptor 142 100.00 Very High Very High Very High
antagonist 119 100.00 Very High Very High Very High
Dynorphin 76 100.00 Very High Very High Very High
Enkephalin 75 100.00 Very High Very High Very High
substance P 60 100.00 Very High Very High Very High
GABAergic 193 99.84 Very High Very High Very High
projection neuron 24 99.74 Very High Very High Very High
Hippocampus 20 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 465 100.00 Very High Very High Very High
Vibrio Infection 2 100.00 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 11 99.16 Very High Very High Very High
Diphtheria 5 98.98 Very High Very High Very High
Basal Ganglia Disease 2 97.64 Very High Very High Very High
Disease 57 96.92 Very High Very High Very High
Death 47 95.28 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 181 94.96 High High
Anxiety Disorder 25 93.36 High High
Psychosis 6 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The recent introduction of drd1a-EGFP and drd2-EGFP bacterial artificial chromosome (BAC) transgenic mice, in which striatonigral and striatopallidal neurons are specifically labeled [9], allowed the demonstration that subpopulations of MSNs display very distinct properties [10]–[17].
Gene_expression (introduction) of drd1a in neurons associated with targeted disruption
1) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.18 Pain Relevance 0.44
As expected, we found that all retrogradely labeled striatonigral neurons were EGFP-positive in drd1a-EGFP mice, whereas only very few (<1%) retrogradely labeled neurons expressed EGFP in drd2-EGFP mice.
Gene_expression (positive) of drd1a in neurons
2) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0 Pain Relevance 0.06
A recent paper elegantly addressed this question by using the drd1a promoter to drive the expression of tdTomato, a red fluorescent protein, in BAC transgenic mice [21].
Gene_expression (expression) of drd1a associated with targeted disruption
3) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.17 Pain Relevance 0.12
However, when these authors crossed drd1a-tdTomato and drd2-EGFP mice, they estimated that up to 39% of MSNs did not express either fluorescent protein in the F1 progeny.
Gene_expression (crossed) of drd1a
4) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.22 Pain Relevance 0.11
The recent introduction of drd1a-EGFP and drd2-EGFP BAC transgenic mice allows an easy identification of D1R-expressing and D2R-expressing neurons [9], [12], [19].
Gene_expression (introduction) of drd1a in neurons associated with targeted disruption
5) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.10 Pain Relevance 0.24
The proportion of unlabeled neurons was even higher (50%) when they crossed drd1a-EGFP and drd2-EGFP mice.
Gene_expression (crossed) of drd1a in neurons
6) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.22 Pain Relevance 0
In drd1a-EGFP/drd2-EGFP double transgenic mice all MSNs expressed EGFP, which was driven in about half of them by drd1a promoter.
Gene_expression (transgenic mice) of drd1a in MSNs associated with targeted disruption
7) Confidence 0.66 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2651623 Disease Relevance 0.24 Pain Relevance 0.18
A high photodetection voltage permitted a correct identification of EGFP neurons in drd1a-EGFP mice (Fig.
Gene_expression (neurons) of drd1a in neurons
8) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.47 Pain Relevance 0.04
On the other hand, observations in our and other laboratories support the existence of a small fraction of D1R-neuron projections to the pallidum, since weak but noticeable staining is present in the LGP of drd1a-Cre, chrm4-EGFP and drd1a-EGFP mice [12], [13], [19].
Gene_expression (present) of drd1a-Cre in neuron
9) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0 Pain Relevance 0
In drd1a-EGFP/drd2-EGFP double transgenic mice all MSNs expressed EGFP, which was driven in about half of them by drd1a promoter.
Gene_expression (expressed) of drd1a in MSNs associated with targeted disruption
10) Confidence 0.66 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2651623 Disease Relevance 0.24 Pain Relevance 0.18
These results clearly demonstrate that all striatal MSNs express either drd1a-EGFP or drd2-EGFP, or both, in double transgenic mice, in sharp contrast to what has been reported recently [21].
Gene_expression (express) of drd1a associated with targeted disruption
11) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.29 Pain Relevance 0.07
Those expressing dopamine D1-receptors (D1Rs) project preferentially to the substantia nigra pars reticulata (SNr), whereas those expressing dopamine D2- receptors (D2Rs) project preferentially to the lateral part of the globus pallidus (LGP).
Gene_expression (project) of D1R in substantia nigra pars reticulata associated with dopamine and substantia nigra
12) Confidence 0.65 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2651623 Disease Relevance 0.15 Pain Relevance 0.19
Direct and indirect striatal projection neurons selectively express the DRD1 and DRD2 dopamine receptor subtypes respectively [29].
Gene_expression (express) of DRD1 in projection neurons associated with dopamine receptor and projection neuron
13) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.32
While no changes in DA release or uptake could be detected by microdialysis, KO animals showed a significant increase in total DA tissue content in dorsal striatum, an effect accompanied by a significant increase in striatal prodynorphin and DRD1 mRNA expression levels.
Gene_expression (expression) of DRD1 mRNA in striatum associated with dopamine
14) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.11 Pain Relevance 0.58
Intriguingly, in all studies using drd1a- and drd2-EGFP mice, ERK activation was never observed in striatopallidal MSNs, not even in the NAc shell, where the calculated D1R/D2R co-expression levels were higher.
Gene_expression (using) of drd1a in shell associated with nucleus accumbens
15) Confidence 0.62 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.08 Pain Relevance 0.33
Moreover, in drd1a-EGFP or drd2-EGFP mice, fluorescence was not detected in GABAergic interneurons, identified using parvalbumin, somatostatin, and calretinin antibodies (Bertran-Gonzalez et al., 2008).
Neg (not) Gene_expression (detected) of drd1a in interneurons associated with gabaergic and somatostatin
16) Confidence 0.62 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.08 Pain Relevance 0.29
Similarly, in DA-depleted drd1a- and drd2-EGFP mice, l-DOPA-induced activation of the ERK pathway was exclusively observed in D1R-expressing neurons (Santini et al., 2009), confirming previous observations (Gerfen et al., 2002).
Gene_expression (expressing) of drd1a in neurons associated with dopamine
17) Confidence 0.62 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.15 Pain Relevance 0.30
Future studies should precisely confirm whether the expression of dynorphin/substance P and enkephalin is also restricted to EGFP labeled neurons in drd1a-EGFP and drd2-EGFP mice, respectively.
Gene_expression (labeled) of drd1a in neurons associated with dynorphin, enkephalin and substance p
18) Confidence 0.62 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.07 Pain Relevance 0.36
In addition, both the dopamine D1 antagonist SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro- 1H-3-benzazepine], the D2 antagonist eticlopride and the dopamine D1/D2 antagonist flupenthixol produced dose-dependent blockade of gnawing induced by either cocaine or methylphenidate.
Gene_expression (produced) of dopamine D1 associated with dopamine, antagonist and cocaine
19) Confidence 0.62 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7714815 Disease Relevance 0 Pain Relevance 1.07
In addition, both the dopamine D1 antagonist SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro- 1H-3-benzazepine], the D2 antagonist eticlopride and the dopamine D1/D2 antagonist flupenthixol produced dose-dependent blockade of gnawing induced by either cocaine or methylphenidate.
Gene_expression (produced) of dopamine D1 associated with dopamine, antagonist and cocaine
20) Confidence 0.62 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7714815 Disease Relevance 0 Pain Relevance 0.92

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