INT5180

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Context Info
Confidence 0.36
First Reported 1990
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 13.39
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinc1) extracellular region (Serpinc1)
Anatomy Link Frequency
hematopoietic stem cell 2
plasma 1
renal vein 1
Serpinc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 24 98.64 Very High Very High Very High
pain flank 1 96.68 Very High Very High Very High
cva 536 93.56 High High
Percutaneous transluminal coronary angioplasty 2 92.40 High High
Potency 5 90.00 High High
Analgesic 3 88.64 High High
bradykinin 5 87.92 High High
Bioavailability 17 86.96 High High
Inflammation 13 79.28 Quite High
antagonist 31 69.20 Quite High
Disease Link Frequency Relevance Heat
Renal Failure 17 99.98 Very High Very High Very High
Acute Liver Failure 9 99.84 Very High Very High Very High
Multiple Organ Failure 12 99.76 Very High Very High Very High
Retinal Vein Occlusion 117 99.66 Very High Very High Very High
Thrombosis 186 99.62 Very High Very High Very High
Syndrome 21 99.60 Very High Very High Very High
Cv General 3 Under Development 89 98.64 Very High Very High Very High
Disseminated Intravascular Coagulation 3 98.24 Very High Very High Very High
Disease 19 97.36 Very High Very High Very High
Bacteremia 2 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recurrent renal vein thrombosis and renal failure associated with antithrombin-III deficiency.
antithrombin-III Binding (associated) of in renal vein associated with renal failure and thrombosis
1) Confidence 0.36 Published 1992 Journal Pediatr. Nephrol. Section Title Doc Link 1571206 Disease Relevance 0.67 Pain Relevance 0.10
In hematopoietic stem cell transplantation (HSCT), acquired antithrombin III (ATIII) deficiency is independently associated with MODS to the exclusion of transplant type, preparative regimen, and bacteremia.
ATIII Binding (associated) of in hematopoietic stem cell associated with multiple organ failure and bacteremia
2) Confidence 0.36 Published 1998 Journal Biol. Blood Marrow Transplant. Section Abstract Doc Link 9923412 Disease Relevance 0.75 Pain Relevance 0.03
In hematopoietic stem cell transplantation (HSCT), acquired antithrombin III (ATIII) deficiency is independently associated with MODS to the exclusion of transplant type, preparative regimen, and bacteremia.
antithrombin III Binding (associated) of in hematopoietic stem cell associated with multiple organ failure and bacteremia
3) Confidence 0.36 Published 1998 Journal Biol. Blood Marrow Transplant. Section Abstract Doc Link 9923412 Disease Relevance 0.75 Pain Relevance 0.03
Antithrombin III supplementation for patients undergoing PTCA for unstable angina pectoris.
Antithrombin Binding (supplementation) of associated with angina
4) Confidence 0.30 Published 1997 Journal Eur. Heart J. Section Title Doc Link 9076381 Disease Relevance 0.46 Pain Relevance 0.37
When the conformationally altered antithrombin binds to factor Xa, fondaparinux is released and can continue the process, acting as a catalyst.
antithrombin Binding (binds) of
5) Confidence 0.16 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994024 Disease Relevance 0.15 Pain Relevance 0.08
The binding between fondaparinux and antithrombin is non-covalent and reversible.
antithrombin Binding (binding) of
6) Confidence 0.16 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994024 Disease Relevance 0.12 Pain Relevance 0.06
The minimum molecular sequence of heparin, which is necessary to bind antithrombin, was shown to be a pentasaccharide described by Lindahl et al (1979) and synthesized by Choay et al (1983) as the pharmacological substance fondaparinux (molecular weight 1728 Da).
antithrombin Binding (bind) of
7) Confidence 0.12 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994024 Disease Relevance 0 Pain Relevance 0
The mixture of polysulfated glycosaminoglycans called heparin binds to and activates antithrombin.
antithrombin Binding (binds) of
8) Confidence 0.12 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994024 Disease Relevance 0.10 Pain Relevance 0.05
Thrombin-antithrombin III complex in fulminant hepatic failure: evidence for disseminated intravascular coagulation and relationship to outcome.
antithrombin III Binding (complex) of associated with disseminated intravascular coagulation and acute liver failure
9) Confidence 0.10 Published 1990 Journal Eur. J. Clin. Invest. Section Title Doc Link 2127751 Disease Relevance 0.95 Pain Relevance 0.06
Heparin is the principal antithrombin drug currently used in acute syndromes; it acts mainly by binding to antithrombin III and increasing its inhibitory effect on thrombin and other coagulation factors.
antithrombin Binding (binding) of associated with syndrome
10) Confidence 0.09 Published 1994 Journal Cardiologia Section Abstract Doc Link 7634317 Disease Relevance 0.84 Pain Relevance 0.07
This new synthetic compound, with no animal-sourced components, has been designed to bind selectively to a single target in the plasma, Antithrombin (AT), which inactivates factor Xa, thus resulting in a strong inhibition of thrombin generation and clot formation.[33] This drug was first approved for venous thromboembolic prophylaxis in patients undergoing major orthopedic procedures.
Antithrombin Binding (bind) of in plasma associated with cva
11) Confidence 0.09 Published 2010 Journal Annals of Thoracic Medicine Section Body Doc Link PMC2954373 Disease Relevance 0.90 Pain Relevance 0.27
Whereas UFH chains of any length containing this unique sequence can bind to antithrombin and promote inactivation of factor Xa, the formation of the ternary complex of UFH-anti-thrombin-thrombin necessary to enhance inhibition of thrombin (factor IIa) can occur only with UFH molecules with > 18 saccharide units.
antithrombin Binding (bind) of
12) Confidence 0.03 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774587 Disease Relevance 0.06 Pain Relevance 0.04
This activation resides on a specific pentasaccharide sequence which has high affinity for antithrombin and is randomly dispersed within the heparin molecule.
antithrombin Binding (affinity) of
13) Confidence 0.03 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774587 Disease Relevance 0.12 Pain Relevance 0.03
The oligosaccharide composition, microstructural differences in terms of specific sugars and the presence of unique structural features and the interaction with endogenous mediators such as antithrombin (AT) and heparin cofactor II (HC II) also differ.
antithrombin Binding (interaction) of
14) Confidence 0.03 Published 2004 Journal Curr. Pharm. Des. Section Abstract Doc Link 15078128 Disease Relevance 0.05 Pain Relevance 0.13
Lastly, fondaparinux is a synthetic pentasaccharide that reproduces the sequence in heparins that mediates their interaction with antithrombin.
antithrombin Binding (interaction) of
15) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2856573 Disease Relevance 0.36 Pain Relevance 0
Indeed an excess of ECP was able to override heparin binding to antithrombin [31] and may well explain the few instances where apparently therapeutic or prophylactic doses of heparin failed to prevent thrombosis [27,32].
antithrombin Binding (binding) of associated with thrombosis
16) Confidence 0.03 Published 2008 Journal Thromb J Section Body Doc Link PMC2390511 Disease Relevance 1.43 Pain Relevance 0.03
Whereas UFH chains of any length containing this unique sequence can bind to antithrombin and promote inactivation of factor Xa, the formation of the ternary complex of UFH-anti-thrombin-thrombin necessary to enhance inhibition of thrombin (factor IIa) can occur only with UFH molecules with > 18 saccharide units.
UFH-anti-thrombin-thrombin Binding (complex) of
17) Confidence 0.03 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774587 Disease Relevance 0.05 Pain Relevance 0.04
Fondaparinux binds to antithrombin with high affinity in a 1:1 stoichiometric and reversible manner (Olson et al 1992).
antithrombin Binding (binds) of
18) Confidence 0.02 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684509 Disease Relevance 0.36 Pain Relevance 0
The most potent direct antithrombin is hirudin, which (unlike heparin) forms a 1:1 complex directly with thrombin.
antithrombin Binding (complex) of
19) Confidence 0.02 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59637 Disease Relevance 0.30 Pain Relevance 0.07
In contrast to unfractionated heparin, the majority of dalteparin chains do not contain the 18 saccharide sequence that is required to simultaneously bind to antithrombin and thrombin.
antithrombin Binding (bind) of
20) Confidence 0.02 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2496976 Disease Relevance 0.44 Pain Relevance 0.10

General Comments

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