INT51817

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Context Info
Confidence 0.65
First Reported 1995
Last Reported 2008
Negated 0
Speculated 3
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 1.40
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pyy) extracellular region (Pyy)
Anatomy Link Frequency
gut 2
descending colon 1
endocrine cells 1
bowel 1
ascending colon 1
Pyy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 4 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
Crohn's disease 29 99.38 Very High Very High Very High
Somatostatin 3 97.60 Very High Very High Very High
narcan 1 94.68 High High
antagonist 4 94.32 High High
opiate 1 93.52 High High
Dopamine 1 86.40 High High
Inflammation 28 86.24 High High
Disease Link Frequency Relevance Heat
Disease 33 99.38 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

6 88.36 High High
Functional Bowel Disorder 9 88.16 High High
INFLAMMATION 24 86.24 High High
Fibrosis 1 83.92 Quite High
Gastric Motility Disorder 9 59.12 Quite High
Inflammatory Bowel Disease 17 45.48 Quite Low
Infection 12 39.32 Quite Low
Constipation 1 38.60 Quite Low
Apoptosis 26 27.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proglucagon, PYY, PPY and CCK are all expressed by enteroendocrine L cells in colon and play a role in gut-nutrient sensing [61].
Gene_expression (expressed) of PYY in gut
1) Confidence 0.65 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2311291 Disease Relevance 0 Pain Relevance 0.05
PYY and NPY produced a dose-related inhibition of 2DG-stimulated pancreatic secretion.
Gene_expression (produced) of PYY
2) Confidence 0.62 Published 1995 Journal Pancreas Section Abstract Doc Link 7716135 Disease Relevance 0 Pain Relevance 0.43
Besides FOS induced expression of proglucagon, FOS induced the expression of several other gut-derived peptide hormones, namely cholecystokinin (Cck), peptide YY (Pyy) and pancreatic polypeptide (Ppy).
Gene_expression (expression) of Pyy in gut associated with cholecystokinin
3) Confidence 0.57 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2311291 Disease Relevance 0 Pain Relevance 0.05
With radioimmunoassay, the levels of vasoactive intestinal peptide (VIP), substance P, neuropeptide Y (NPY) and peptide YY (PYY) were analysed in biopsies from the descending colon and ascending colon obtained during colonoscopy.
Spec (analysed) Gene_expression (levels) of PYY in ascending colon
4) Confidence 0.24 Published 2003 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 12544695 Disease Relevance 0.09 Pain Relevance 0
No differences in fasting and postprandial motilin or PYY levels were found.
Gene_expression (levels) of PYY
5) Confidence 0.17 Published 2006 Journal Scand. J. Gastroenterol. Section Body Doc Link 16484122 Disease Relevance 0 Pain Relevance 0
Changes in plasma levels of motilin and PYY may contribute to the clinical expression of IBS, such as the presence of visceral hypersensitivity or a predominant bowel habit.


Gene_expression (levels) of PYY in bowel
6) Confidence 0.17 Published 2006 Journal Scand. J. Gastroenterol. Section Body Doc Link 16484122 Disease Relevance 0 Pain Relevance 0
It has been shown that patients with Crohn's disease have elevated serum levels of PYY [14], which could be a possible explanation for upper gastrointestinal motility disturbance in these patients.
Spec (possible) Gene_expression (explanation) of PYY in upper associated with crohn's disease and disease
7) Confidence 0.11 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1838914 Disease Relevance 0.92 Pain Relevance 0.40
With radioimmunoassay, the levels of vasoactive intestinal peptide (VIP), substance P, neuropeptide Y (NPY) and peptide YY (PYY) were analysed in biopsies from the descending colon and ascending colon obtained during colonoscopy.
Spec (analysed) Gene_expression (levels) of PYY in descending colon
8) Confidence 0.08 Published 2003 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 12544695 Disease Relevance 0.09 Pain Relevance 0
Gastric endocrine cells expressing 5-HT, glucagon, insulin, met-, leu-enkephalin, substance P, PYY, VIP, CCK, NPY, bombesin and motilin were unreactive for Trk-like proteins.
Gene_expression (expressing) of PYY in endocrine cells associated with enkephalin and substance p
9) Confidence 0.08 Published 1999 Journal Anat. Rec. Section Abstract Doc Link 10521780 Disease Relevance 0 Pain Relevance 0.32

General Comments

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