INT51819

Context Info Confidence 0.49 First Reported 1994 Last Reported 2000 Negated 2 Speculated 0 Reported most in Abstract Documents 8 Total Number 8 Disease Relevance 4.50 Pain Relevance 4.00

extracellular space (MSMB) extracellular region (MSMB) nucleus (MSMB) molecular_function (MSMB) biological_process (MSMB)

Anatomy Link Frequency PSP 8 MSMB (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 27 99.92 Paracetamol 11 99.92 lidocaine 6 99.50 antagonist 3 95.40 Clonidine 2 82.96 amygdala 2 75.00 local anesthetic 1 65.96

Disease Link Frequency Relevance Heat Supranuclear Palsy 12 100.00 Pancreatitis 32 99.92 Multiple System Atrophy 10 99.60 Renal Disease 2 98.20 Stress 1 96.52 Parkinsonian Disorders 1 95.56 Hepatotoxicity 3 76.96 Pressure Volume 2 Under Development 1 64.80 Aids-related Complex 1 56.00 Urological Neuroanatomy 1 51.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

No significant reduction of PSP was observed in either calcified (mean +/- SEM, 111 +/- 30 micrograms/mg and 24 +/- 3 micrograms/mg protein) or noncalcified (305 +/- 133 and 97 +/- 47) chronic pancreatitis patients compared with controls (85 +/- 23 and 34 +/- 16).

Neg (No) Negative_regulation (reduction) of PSP in PSP associated with chronic pancreatitis

1) Confidence 0.49 Published 1995 Journal Pancreas Section Abstract Doc Link 7716137 Disease Relevance 0.59 Pain Relevance 0.60

PSP levels did not decrease, at least not in the complete forms of the protein found in chronic pancreatitis.

Neg (not) Negative_regulation (decrease) of PSP in PSP associated with chronic pancreatitis

2) Confidence 0.49 Published 1995 Journal Pancreas Section Abstract Doc Link 7716137 Disease Relevance 0.57 Pain Relevance 0.62

PSP antibody and assay results indicated that a reduction of PSP S2-5 alone could not be ruled out in chronic pancreatitis either.

Negative_regulation (reduction) of PSP in PSP associated with chronic pancreatitis

3) Confidence 0.49 Published 1995 Journal Pancreas Section Abstract Doc Link 7716137 Disease Relevance 0.64 Pain Relevance 0.60

PSP was initially reported to inhibit calcium carbonate precipitation from human pancreatic juice and to be decreased in pancreatic secretions from patients with chronic pancreatitis.

Negative_regulation (decreased) of PSP in PSP associated with chronic pancreatitis

4) Confidence 0.43 Published 1994 Journal Nagoya J Med Sci Section Abstract Doc Link 7898566 Disease Relevance 0.44 Pain Relevance 0.28

However, the PSP reduction in pancreatic secretion in chronic pancreatitis remains controversial.

Negative_regulation (reduction) of PSP in PSP associated with chronic pancreatitis

5) Confidence 0.37 Published 1994 Journal Nagoya J Med Sci Section Abstract Doc Link 7898566 Disease Relevance 0.48 Pain Relevance 0.28

PSP dose-dependently decreased the covalent binding of [14C]-paracetamol to microsomal proteins in vitro.

Negative_regulation (decreased) of PSP in PSP associated with paracetamol

6) Confidence 0.31 Published 1994 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 7723471 Disease Relevance 0.31 Pain Relevance 0.91

None of the lidocaine infusions into the mPOA prevented the establishment of PSP, and neither verapamil infusions into the mAMYG nor the shorter-term neural block (i.e. single or double lidocaine infusions) of the mAMYG prevented mating-induced PSP.

Negative_regulation (prevented) of PSP in PSP associated with lidocaine

7) Confidence 0.03 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8861281 Disease Relevance 0.11 Pain Relevance 0.64

Autonomic dysfunction is a characteristic of MSA, but has also been described in PSP.

Negative_regulation (described) of PSP in PSP associated with supranuclear palsy and multiple system atrophy

8) Confidence 0.02 Published 2000 Journal Brain Section Abstract Doc Link 10869054 Disease Relevance 1.37 Pain Relevance 0.08

General Comments

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