INT51839

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 9
Disease Relevance 7.09
Pain Relevance 4.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PLAT) protein modification process (PLAT) extracellular space (PLAT)
extracellular region (PLAT) cytoplasm (PLAT)
Anatomy Link Frequency
forearm 3
HL-60 2
vessels 2
Plaques 2
vasculature 1
PLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 80 99.98 Very High Very High Very High
Migraine 380 99.64 Very High Very High Very High
narcan 1 98.56 Very High Very High Very High
cva 6 96.32 Very High Very High Very High
Morphine 1 95.64 Very High Very High Very High
Pain 3 94.24 High High
mu opioid receptor 9 93.76 High High
headache 50 92.64 High High
depression 25 85.12 High High
Angina 1 84.00 Quite High
Disease Link Frequency Relevance Heat
Headache 375 99.64 Very High Very High Very High
Stress 4 99.08 Very High Very High Very High
Increased Venous Pressure Under Development 40 99.04 Very High Very High Very High
Aseptic Necrosis Of Bone 6 97.60 Very High Very High Very High
Hemorrhage 6 96.32 Very High Very High Very High
Epilepsy 75 95.68 Very High Very High Very High
Pain 3 94.24 High High
Depression 25 85.12 High High
Cv General 3 Under Development 1 84.00 Quite High
Leukemia 1 83.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In three of the four patients with high PAI and with osteonecrosis present 0.3, 2, and 6 years prior to Stanozolol Rx, there was no clinical improvement after 14-156 weeks of Rx despite normalization of stimulated tPA-Fx and PAI-Fx.
Positive_regulation (stimulated) of Localization (normalization) of tPA associated with aseptic necrosis of bone
1) Confidence 0.49 Published 1995 Journal Am. J. Hematol. Section Abstract Doc Link 7717367 Disease Relevance 0.58 Pain Relevance 0.27
In conclusion, the absence of differences in endothelium-dependent vasodilation, basal endothelial nitric oxide production and stimulated t-PA release between migraine patients and healthy control subjects argues against the presence of endothelial dysfunction in forearm resistance vessels of migraine patients.


Positive_regulation (stimulated) of Localization (release) of t-PA in forearm associated with migraine and increased venous pressure under development
2) Confidence 0.46 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0.76 Pain Relevance 0.46
If CRHBP does not function appropriately it may prevent the inactivation of CRH, causing the release of tPA and the activation of stress related response.
Positive_regulation (causing) of Localization (release) of tPA associated with stress
3) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.50 Pain Relevance 0.11
In both groups, substance P caused an increase in t-PA release (P < 0.001).
Positive_regulation (increase) of Localization (release) of t-PA associated with substance p
4) Confidence 0.31 Published 2010 Journal BMC Neurol Section Abstract Doc Link PMC3017034 Disease Relevance 0.92 Pain Relevance 0.79
To this end, endothelial function was assessed in vivo in the human forearm resistance vasculature by measuring: (1) stimulated endothelial NO release, (2) basal endothelial NO release and (3) stimulated endothelial t-PA release.


Positive_regulation (stimulated) of in forearm Localization (release) of t-PA in vasculature
5) Confidence 0.31 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 1.45 Pain Relevance 0.71
The absence of differences in endothelium-dependent vasodilation, basal endothelial nitric oxide production and stimulated t-PA release between migraine patients and healthy control subjects argues against the presence of endothelial dysfunction in forearm resistance vessels of migraine patients.



Positive_regulation (stimulated) of Localization (release) of t-PA in vessels associated with migraine and increased venous pressure under development
6) Confidence 0.31 Published 2010 Journal BMC Neurol Section Abstract Doc Link PMC3017034 Disease Relevance 0.92 Pain Relevance 0.84
In both groups, substance P caused an increase in t-PA release (P < 0.001).
Positive_regulation (caused) of Localization (release) of t-PA associated with substance p
7) Confidence 0.31 Published 2010 Journal BMC Neurol Section Abstract Doc Link PMC3017034 Disease Relevance 0.92 Pain Relevance 0.80
Exposure to gp120 also stimulated the release of TNF-alpha from TPA-differentiated HL-60 cells.
Positive_regulation (stimulated) of Localization (release) of TPA in HL-60
8) Confidence 0.17 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16846840 Disease Relevance 0.64 Pain Relevance 0.69
Plaques from unstable patients had an increased infiltration of macrophages and T-lymphocytes, nuclear localisation of AP-1 and the NF-kappaB subunit p65, as well as increased positive immunostaining for MMP9 and tPA.
Positive_regulation (increased) of Localization (localisation) of tPA in Plaques
9) Confidence 0.05 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15583828 Disease Relevance 0.40 Pain Relevance 0.25

General Comments

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