INT51840

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 9.59
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD40LG) extracellular region (CD40LG) plasma membrane (CD40LG)
Anatomy Link Frequency
platelets 5
plasma 3
blood 2
B lymphocytes 2
CD40LG (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1 98.72 Very High Very High Very High
Arthritis 83 98.22 Very High Very High Very High
cytokine 49 98.12 Very High Very High Very High
Inflammatory marker 6 96.36 Very High Very High Very High
rheumatoid arthritis 11 89.80 High High
Inflammation 50 89.32 High High
Pain 16 88.92 High High
Action potential 1 84.24 Quite High
palliative 1 80.72 Quite High
ischemia 24 77.48 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 155 100.00 Very High Very High Very High
Systemic Sclerosis 64 100.00 Very High Very High Very High
Injury 54 100.00 Very High Very High Very High
Hemorrhage 19 100.00 Very High Very High Very High
Diabetes Mellitus 162 99.84 Very High Very High Very High
Malignant Neoplastic Disease 5 99.40 Very High Very High Very High
Syndrome 14 98.80 Very High Very High Very High
Dysesthesia 2 98.80 Very High Very High Very High
Acute Coronary Syndrome 28 98.70 Very High Very High Very High
Juvenile Chronic Polyarthritis 73 98.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data in humans and animals suggest that the spleen may facilitate IgM secretion by normal and malignant B lymphocytes.
Spec (may) Positive_regulation (facilitate) of Localization (secretion) of IgM in B lymphocytes associated with malignant neoplastic disease
1) Confidence 0.69 Published 1995 Journal Am. J. Hematol. Section Abstract Doc Link 7717376 Disease Relevance 0.68 Pain Relevance 0.08
It is conceivable that the activated CD4 T-cells in JIA synovium may be the source of sCD154, although it is possible that other cells, such as activated platelets release sCD154.
Positive_regulation (activated) of Localization (release) of sCD154 in platelets associated with arthritis
2) Confidence 0.35 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.57 Pain Relevance 0.60
In our study, it is possible that UFP exposure caused both an increase in platelet expression of CD40L and a more rapid clearance of CD40L from the plasma.
Positive_regulation (increase) of in platelet Localization (clearance) of CD40L in plasma
3) Confidence 0.28 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.23 Pain Relevance 0
In patients with HF, the abundance of CD154 on platelets is increased and correlates with New York Heart Association classification [94].
Positive_regulation (increased) of Localization (abundance) of CD154 in platelets associated with myocardial infarction
4) Confidence 0.27 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.14 Pain Relevance 0.37
It is also possible that platelet activation does not always lead to release of CD40L into the plasma.
Neg (not) Positive_regulation (lead) of Localization (release) of CD40L in plasma
5) Confidence 0.26 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.27 Pain Relevance 0.11
Though the phenomenon is poorly understood, we believe that false positives in IgM serology could be due to other immunological factors, and this may also be the case for CHIKV infection.
Positive_regulation (due) of Localization (serology) of IgM associated with infection
6) Confidence 0.16 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2907414 Disease Relevance 0.67 Pain Relevance 0
Importantly, a similar increase in sCD40L release correlated with thrombin formation has been reported in patients with the metabolic syndrome (24).
Positive_regulation (increase) of Localization (release) of sCD40L associated with metabolic syndrome
7) Confidence 0.14 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.80 Pain Relevance 0
In one report of long-standing SSc with the presence of cryoglobulins (both IgG and IgM), the patient presented with paresthesias, transient aphasia, vision changes, and delirium [30] (Table 2).
Positive_regulation (standing) of Localization (presence) of IgM associated with dysesthesia, delirium, systemic sclerosis and aphasia
8) Confidence 0.11 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2952802 Disease Relevance 1.82 Pain Relevance 0.17
Profiles of sCD40L release, reflected in its levels in blood obtained from bleeding time wounds, shared common kinetics in acute myocardial infarction patients, with the steepest increase in diabetic subjects (Fig. 1B).
Positive_regulation (increase) of Localization (release) of sCD40L in blood associated with diabetes mellitus, injury, hemorrhage and myocardial infarction
9) Confidence 0.10 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.86 Pain Relevance 0.17
RESULTS—The acute coronary syndrome patients with no prior diabetes but elevated glucose levels had increased maximum rates of formation and total production of TATs (by 42.9%, P < 0.0001, and by 25%, P < 0.0001, respectively) as well as sCD40L release (by 16.2%, P = 0.0011, and by 16.3%, P < 0.0001, respectively) compared with those with normoglycemia, whereas diabetic patients had the highest values of TATs and sCD40L variables (P < 0.0001 for all comparisons).
Positive_regulation (increased) of Localization (release) of sCD40L associated with acute coronary syndrome and diabetes mellitus
10) Confidence 0.09 Published 2008 Journal Diabetes Care Section Abstract Doc Link PMC2494657 Disease Relevance 1.56 Pain Relevance 0.08

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