INT51841

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 17
Disease Relevance 6.82
Pain Relevance 3.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CHPT1) lipid metabolic process (CHPT1)
Anatomy Link Frequency
tear 2
amygdala 2
eyes 1
spinal 1
nerve 1
CHPT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 170 100.00 Very High Very High Very High
Catecholamine 3 100.00 Very High Very High Very High
amygdala 243 99.98 Very High Very High Very High
Pain 138 97.84 Very High Very High Very High
Neuropeptide 120 97.52 Very High Very High Very High
abdominal pain 1 96.64 Very High Very High Very High
adenocard 6 94.64 High High
unmyelinated 8 92.48 High High
c fibre 1 55.36 Quite High
anesthesia 12 50.00 Quite Low
Disease Link Frequency Relevance Heat
Hypersensitivity 190 98.64 Very High Very High Very High
Pruritus 30 98.64 Very High Very High Very High
Colon Cancer 8 98.32 Very High Very High Very High
Pain 76 97.84 Very High Very High Very High
Increased Venous Pressure Under Development 58 97.00 Very High Very High Very High
Vomiting 1 96.96 Very High Very High Very High
Abdominal Pain 1 96.64 Very High Very High Very High
Stress 39 96.48 Very High Very High Very High
Toxicity 4 96.32 Very High Very High Very High
Cancer 86 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CPT versus anticipation of heat +CPT, i.e., to directly examine the degree to which engagement in the CPT affected amygdala activity during aversive anticipation; 2) anticipation of heat +CPT/RT versus anticipation of heat ?
Positive_regulation (anticipation) of CPT in amygdala associated with amygdala
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0 Pain Relevance 0.32
Seven nuisance regressors were included: two cue regressors (i.e., warning subjects of the upcoming +CPT/?
Positive_regulation (upcoming) of CPT
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.14 Pain Relevance 0.14
Decreased amygdala activation during +CPT relates to RT period
Positive_regulation (activation) of CPT in amygdala associated with amygdala
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.10 Pain Relevance 0.59
Conduction block attenuated the increase in response to CPT only in mean arterial pressure (spinal and epidural) and cardiac index (spinal only).
Positive_regulation (increase) of CPT in spinal
4) Confidence 0.41 Published 1995 Journal Anesthesiology Section Body Doc Link 7717558 Disease Relevance 0 Pain Relevance 0
(F) Two independent spatial clusters of EEG activation, fronto-temporal delta-theta-beta activities and posterior parietal alpha activities emerged during CPT.
Positive_regulation (activation) of CPT in parietal
5) Confidence 0.41 Published 2002 Journal Brain Res. Bull. Section Abstract Doc Link 11927371 Disease Relevance 0.08 Pain Relevance 0
After 7 courses, because of serum CEA elevation, bi-weekly CPT-11/CDDP therapy (CPT-11 60 mg/m2, CDDP 30 mg/m2) was administered followed by weekly PTX therapy (65 mg/m2 day 1, 7, 14; total of 4 weeks).
Positive_regulation (elevation) of CPT-11
6) Confidence 0.41 Published 2010 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 20647726 Disease Relevance 1.03 Pain Relevance 0.10
Maximal mean diastolic velocities were used to calculate the percentage increase of coronary flow velocity during CPT to baseline and coronary flow velocity reserve (CFR) as previously described [19].
Positive_regulation (increase) of CPT
7) Confidence 0.40 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2427009 Disease Relevance 0 Pain Relevance 0.05
[A case of ascending colon cancer with enlarged metastatic lymph nodes around superior mesenteric arterial root that responded dramatically to S-1 and CPT-11 combination chemotherapy].
Positive_regulation (responded) of CPT-11 in superior associated with colon cancer
8) Confidence 0.37 Published 2007 Journal Gan To Kagaku Ryoho Section Title Doc Link 17496457 Disease Relevance 0.58 Pain Relevance 0.10
Current perception threshold (CPT), a neuroselective test, measures sensory nerve conduction threshold in three nerve fiber populations—large myelinated (A?)
Positive_regulation (conduction) of CPT in nerve
9) Confidence 0.36 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1314913 Disease Relevance 0.36 Pain Relevance 0.14
Ten min after starting the CPT, the paper was removed and BP, HR, and Ts were observed for an additional 20 min.
Positive_regulation (starting) of CPT
10) Confidence 0.32 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2259378 Disease Relevance 0.29 Pain Relevance 0.29
At slaughter, the activity of tyrosine hydroxylase, a catecholamine-synthesizing enzyme, was increased in mixed bulls (1.52 vs. 1.16 nmol.h(-1).mg(-1), P < 0.05), which may indicate chronic stress.
Positive_regulation (increased) of catecholamine-synthesizing enzyme associated with stress and catecholamine
11) Confidence 0.25 Published 2005 Journal J. Anim. Sci. Section Abstract Doc Link 15956479 Disease Relevance 0.43 Pain Relevance 0.16
However, using a “paired Wilcoxon Rank test” for statistical analysis –which analyses the magnitude of the difference in paired samples– allowed us to convincingly demonstrate the increase of SP, CGRP and VIP tear levels after CPT only in eyes challenged with allergen.
Positive_regulation (increase) of CPT in eyes associated with substance p
12) Confidence 0.09 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.93 Pain Relevance 0.32
The similarity of mean neuropeptide levels before and after challenge with allergen and with diluent, apparently in contrast with our results showing a significant increase in the CPT group only, may be explained by the high variability in tear neuropeptide levels observed among individuals.
Positive_regulation (increase) of CPT in tear associated with neuropeptide
13) Confidence 0.09 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.61 Pain Relevance 0.38
NPY tear levels showed no significant changes before and after CPT as compared to baseline values (2.7±0.4 versus 3.3±1.3 ng/ml, respectively, p=NSS; Figure 2).
Positive_regulation (changes) of CPT in tear
14) Confidence 0.06 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.29 Pain Relevance 0.33
All allergic patients (100%) showed positive conjunctival reaction to CPT at a mean threshold dose of 1.7±3.1 BU/ml, evidenced by a significant increase of total CPT score (0 versus 3.9±1; p=0.001), itching (0 versus 1.5±0.6; p=0.026), and hyperemia (mean: 0 versus 2.2±0.5; p=0.023).
Positive_regulation (increase) of CPT associated with pruritus, hypersensitivity and increased venous pressure under development
15) Confidence 0.06 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.45 Pain Relevance 0.39
In allergic patients SP, CGRP, and VIP, but not NPY, were significantly higher after CPT as compared to baseline (SP: 3.9±1.3 ng/ml versus 5.8±1.1 ng/ml, p=0.011; CGRP: 5.5±2.3 ng/ml versus 7.3±2.7 ng/ml; p=0.002; VIP: 4±0.9 ng/ml versus 5.1±1.5 ng/ml, p=0.007).
Positive_regulation (after) of CPT associated with hypersensitivity and substance p
16) Confidence 0.06 Published 2011 Journal Molecular Vision Section Abstract Doc Link PMC3021574 Disease Relevance 0.75 Pain Relevance 0.31
Intriguingly, while DMC dramatically increased the cytotoxicity of CPT-11, no such enhancing effect was observed in combination with temozolomide (Figure 6).
Positive_regulation (increased) of CPT-11
17) Confidence 0.01 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.76 Pain Relevance 0

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