INT51843

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Context Info
Confidence 0.62
First Reported 1994
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.54
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsl1) extracellular region (Ctsl1) histone binding (Ctsl1)
vacuole (Ctsl1) lysosome (Ctsl1) cytoplasm (Ctsl1)
Anatomy Link Frequency
temporomandibular joint 1
lining cells 1
Ctsl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 6 99.56 Very High Very High Very High
Snapping jaw 4 98.36 Very High Very High Very High
Spinal cord 33 89.76 High High
Action potential 2 70.56 Quite High
Eae 1 29.40 Quite Low
cytokine 7 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Dismenorea 2 5.00 Very Low Very Low Very Low
Sciatic nerve 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 13 98.72 Very High Very High Very High
Temporomandibular Joint Syndrome 4 98.36 Very High Very High Very High
Spinal Cord Injury 25 39.12 Quite Low
Paralysis 2 33.28 Quite Low
Cicatrix 5 5.00 Very Low Very Low Very Low
Familial Adenomatous Polyposis 4 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Contusions 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Localization of cathepsin L in the synovial lining cells of the normal rat temporomandibular joint was investigated by the avidin-biotin-peroxidase complex method for semithin (1 microns) cryosections and the colloidal gold-labelled IgG method for ultrathin sections of LR gold resin.
Spec (investigated) Localization (Localization) of cathepsin L in temporomandibular joint associated with snapping jaw
1) Confidence 0.62 Published 1994 Journal Arch. Oral Biol. Section Abstract Doc Link 7717886 Disease Relevance 0.17 Pain Relevance 0.17
Immunocytochemical localization of cathepsin L in the synovial lining cells of the rat temporomandibular joint.
Localization (localization) of cathepsin L in lining cells associated with snapping jaw
2) Confidence 0.62 Published 1994 Journal Arch. Oral Biol. Section Title Doc Link 7717886 Disease Relevance 0.19 Pain Relevance 0.19
Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (uPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.
Localization (tissue) of cathepsin L associated with metalloproteinase
3) Confidence 0.26 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.05
In control animals, MEP did not recover over time, indicating that interruption of supraspinal axons was maintained until the end of the observation period (Fig. 4A).
Neg (not) Localization (recover) of MEP
4) Confidence 0.08 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2996083 Disease Relevance 0.17 Pain Relevance 0.12

General Comments

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