INT51847

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.68
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
macrophage 1
leukocytes 1
fibroblasts 1
oligodendrocyte 1


Pain Term Frequency Confidence Heat
cytokine 43 100.00 Very High Very High Very High
Inflammation 69 100.00 Very High Very High Very High
agonist 37 97.84 Very High Very High Very High
Pain 7 97.24 Very High Very High Very High
Eae 8 96.48 Very High Very High Very High
antagonist 4 92.28 High High
metalloproteinase 4 83.28 Quite High
Sciatica 4 82.32 Quite High
Peripheral nerve injury 2 75.00 Quite High
Sciatic nerve 2 73.28 Quite High
Disease Term Frequency Confidence Heat
Necrosis 10 100.00 Very High Very High Very High
INFLAMMATION 77 100.00 Very High Very High Very High
Cancer 26 100.00 Very High Very High Very High
Aging 20 99.52 Very High Very High Very High
Non-diabetic Peripheral Neuropathy 1 97.46 Very High Very High Very High
Injury 23 96.48 Very High Very High Very High
Adhesions 11 93.44 High High
Pain 2 88.28 High High
Frailty 12 82.96 Quite High
Nerve Root Compression 4 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic constriction injury (CCI) to peripheral nerve causes a painful neuropathy in association with a process of axonal degeneration and endoneural remodeling that involves macrophage recruitment and local increase in extracellular proteases and tumor necrosis factor alpha (TNF-alpha).
Positive_regulation (increase) of tumor necrosis factor alpha in macrophage associated with pain, necrosis, cancer, eae and injury
1) Confidence 0.67 Published 2000 Journal Brain Res. Section Abstract Doc Link 10650133 Disease Relevance 0.82 Pain Relevance 0.52
Concurrently, cortisol (0.01 approximately 1 microM) decreased rather than increased proinflammatory cytokine mRNA levels, including interleukin 1 beta (IL1B), interleukin 6 (IL6), and tumor necrosis factor alpha (TNF), in a dose-dependent manner in human amnion fibroblasts.
Positive_regulation (increased) of tumor necrosis factor alpha in fibroblasts associated with necrosis, cancer and cytokine
2) Confidence 0.67 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17901074 Disease Relevance 0.27 Pain Relevance 0.17
In these infiltrates a high amount of tumor necrosis factor alpha (TNF alpha) mRNA and, near the site of new bone formation, a lower amount of transforming growth factor beta (TGF beta) mRNA, were detected, while no message for interleukin-1 was found in the 3 patients examined by this technique.
Neg (no) Positive_regulation (message) of tumor necrosis factor alpha
3) Confidence 0.49 Published 1995 Journal Arthritis Rheum. Section Body Doc Link 7718003 Disease Relevance 0.14 Pain Relevance 0
In these infiltrates a high amount of tumor necrosis factor alpha (TNF alpha) mRNA and, near the site of new bone formation, a lower amount of transforming growth factor beta (TGF beta) mRNA, were detected, while no message for interleukin-1 was found in the 3 patients examined by this technique.
Positive_regulation (amount) of tumor necrosis factor alpha
4) Confidence 0.49 Published 1995 Journal Arthritis Rheum. Section Body Doc Link 7718003 Disease Relevance 0.14 Pain Relevance 0
Activation of these transcription factors results in induction of immune and inflammatory genes, namely, tumor necrosis factor alpha (TNF-?)
Positive_regulation (induction) of tumor necrosis factor alpha associated with necrosis, inflammation and cancer
5) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.39 Pain Relevance 0.28
Two strong correlates of aging and insulin-resistance include adiponectin and tumor necrosis factor alpha (TNF-?)
Positive_regulation (include) of tumor necrosis factor alpha associated with necrosis, aging and cancer
6) Confidence 0.49 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 1.01 Pain Relevance 0
Moreover, ropivacaine inhibited the tumor necrosis factor alpha-induced up-regulation of CD11b/CD18 and L-selectin shedding by human leukocytes in vitro.
Positive_regulation (up-regulation) of tumor necrosis factor alpha in leukocytes associated with necrosis and cancer
7) Confidence 0.45 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9336308 Disease Relevance 0.87 Pain Relevance 0.16
COX-2 has been focused as a key enzyme to regulate PGE2 synthesis and plays an important role in inflammation, because COX-2 was induced in many types of cells by the stimulation of inflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha).
Positive_regulation (stimulation) of tumor necrosis factor alpha associated with necrosis, inflammation, cancer and cytokine
8) Confidence 0.45 Published 2000 Journal Kobe J Med Sci Section Abstract Doc Link 11193500 Disease Relevance 1.06 Pain Relevance 0.67
Consistent with this hypothesis, PPAR agonists have been shown to inhibit myelin oligodendrocyte glycoprotein-, cytokine-, and lipopolysaccharide-induced increases in proinflammatory mediators such as tumor necrosis factor alpha (TNF?)
Positive_regulation (increases) of tumor necrosis factor alpha in oligodendrocyte associated with necrosis, cancer, agonist and cytokine
9) Confidence 0.45 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 0.99 Pain Relevance 0.48

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