INT51848

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 9.57
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Anatomy Link Frequency
lymph node 1
livers 1
fibroblasts 1
extracellular matrix 1
mesangial cells 1
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 12 99.48 Very High Very High Very High
fibrosis 88 98.96 Very High Very High Very High
cytokine 154 98.80 Very High Very High Very High
agonist 27 98.50 Very High Very High Very High
Inflammation 169 97.76 Very High Very High Very High
tolerance 5 95.04 Very High Very High Very High
Sciatic nerve 3 89.08 High High
anesthesia 17 87.92 High High
epidural 1 87.48 High High
Spinal cord 8 86.88 High High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 11 99.48 Very High Very High Very High
Hypoxia 63 99.36 Very High Very High Very High
Fibrosis 71 98.96 Very High Very High Very High
Spinal Cord Injury 62 98.64 Very High Very High Very High
INFLAMMATION 179 97.76 Very High Very High Very High
Necrosis 12 97.58 Very High Very High Very High
Cancer 52 97.40 Very High Very High Very High
Adhesions 258 96.48 Very High Very High Very High
Death 35 96.40 Very High Very High Very High
Targeted Disruption 3 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TGFbeta mRNA expression was increased in epithelial cells exposed to fibroblasts but not to mast cells.
Transcription (expression) of TGFbeta in fibroblasts
1) Confidence 0.69 Published 2010 Journal Regul. Pept. Section Body Doc Link 20079377 Disease Relevance 0 Pain Relevance 0
Increased TGF-beta(1) transcription and translation were associated with enhanced synthesis of extracellular matrix components including the collagen types I and III as shown by immunocytochemistry and enhanced incorporation of [3H]proline.
Transcription (transcription) of TGF-beta in extracellular matrix
2) Confidence 0.53 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12798441 Disease Relevance 0.17 Pain Relevance 0
There have also been recent studies that have suggested “crosstalk” between the Wnt signalling pathway and the TGF-?
Transcription (pathway) of TGF
3) Confidence 0.43 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.75 Pain Relevance 0
Total RNA was isolated from the control, TGF-?
Transcription (isolated) of TGF
4) Confidence 0.36 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.93 Pain Relevance 0
We used this ex vivo model to study mRNA expressions of NKp46 (a uNK cytotoxic receptor) and TGF-beta1 (protein which regulates uNK cytokine production) after adjunction of excess of recombinant IL-18 and either recombinant TWEAK or its antibody.
Transcription (expressions) of TGF-beta1 associated with cytokine
5) Confidence 0.34 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017546 Disease Relevance 0.30 Pain Relevance 0.05
, and the extent of fibrosis and myofibroblast induction appears related to the level of TGF-?
Transcription (level) of TGF associated with fibrosis
6) Confidence 0.34 Published 2002 Journal Respir Res Section Body Doc Link PMC64807 Disease Relevance 1.43 Pain Relevance 0.62
More relevant to the present study are the reports [4,8] on the mRNA levels of human type I collagen (alpha 2), fibronectin 1, MMP-1, TIMP-1, TGF-?
Transcription (levels) of TGF
7) Confidence 0.28 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.83 Pain Relevance 0.04
In a pro-inflammatory environment (obtained by an excess of IL-18), inhibition of TWEAK was able to increase significantly NKp46 and TGF-beta1 mRNA expressions.


Transcription (expressions) of TGF-beta1 associated with inflammation
8) Confidence 0.27 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017546 Disease Relevance 0.16 Pain Relevance 0.08
We measured serum mRNA levels of 11 genes (MMP9, CRP, HMGB1, MUC1, EGR1, PBEF1, PDGFA, TGF-?
Transcription (levels) of TGF
9) Confidence 0.24 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.37 Pain Relevance 0.49
The mRNA levels for the TGF?
Transcription (levels) of TGF
10) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.13 Pain Relevance 0.03
Increased mRNA expression for IFN-gamma and TNF-alpha was registered correlating with the peak of clinical signs of EAN, and high levels of mRNA expression for IL-4, IL-10, and TGF-beta were associated with EAN recovery.
Transcription (expression) of TGF-beta associated with neuritis
11) Confidence 0.08 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530887 Disease Relevance 1.09 Pain Relevance 1.15
The elevated levels of pSTAT3Ser were comparable in cells treated with LIF either in the presence or absence of EGF or TGF?
Transcription (presence) of TGF
12) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0 Pain Relevance 0.06
agonists inhibited the Smad signaling pathway in the renal fibroblasts and blocked TGF-beta/Smad-mediated gene transcription in mesangial cells (22).
Transcription (transcription) of TGF-beta in mesangial cells associated with agonist
13) Confidence 0.08 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2799997 Disease Relevance 0.24 Pain Relevance 0.26
The expression pattern of IL4, IL10 and TGF® mRNA levels was analyzed following peptide-specific stimulation.
Transcription (levels) of TGF
14) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.28 Pain Relevance 0.16
Transforming growth factor beta transcription is also increased with CNI use which may affect the development of fibrosis in transplanted livers.
Transcription (transcription) of Transforming growth factor beta in livers associated with fibrosis
15) Confidence 0.06 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.15 Pain Relevance 0.14
Numbers of AChR-, MBP-, BPM-reactive Th1 type of cytokine interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha mRNA expression in lymph node cells were markedly suppressed, while transforming growth factor-beta (TGF-beta) mRNA expression was upregulated from nasally tolerized rats, suggesting an active suppression mechanism may act partly in the induction of tolerance.
Transcription (expression) of TGF-beta in lymph node associated with necrosis, cancer, tolerance and cytokine
16) Confidence 0.04 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9562316 Disease Relevance 1.00 Pain Relevance 0.46
In these infiltrates a high amount of tumor necrosis factor alpha (TNF alpha) mRNA and, near the site of new bone formation, a lower amount of transforming growth factor beta (TGF beta) mRNA, were detected, while no message for interleukin-1 was found in the 3 patients examined by this technique.
Neg (no) Transcription (detected) of TGF beta
17) Confidence 0.03 Published 1995 Journal Arthritis Rheum. Section Body Doc Link 7718003 Disease Relevance 0.13 Pain Relevance 0
In addition, mRNA levels for TGF-?
Transcription (levels) of TGF
18) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.61 Pain Relevance 0

General Comments

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