INT51855

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Context Info
Confidence 0.23
First Reported 1993
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cebpa) mitochondrion organization (Cebpa) nucleus (Cebpa)
DNA binding (Cebpa) protein complex (Cebpa) transcription factor binding (Cebpa)
Cebpa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Gabapentin 6 98.02 Very High Very High Very High
Dopamine 5 97.72 Very High Very High Very High
dopamine receptor 1 95.64 Very High Very High Very High
withdrawal 1 84.36 Quite High
cerebral cortex 1 68.80 Quite High
Enkephalin 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of a submaximal concentration of leucine reduced [3H]gabapentin binding affinity but did not affect the maximum number of binding sites, suggesting a competitive interaction between leucine and the binding protein.
binding protein Binding (interaction) of associated with gabapentin
1) Confidence 0.23 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8307106 Disease Relevance 0 Pain Relevance 0.51
CRE-binding protein (CREB) binds to these CREs in striatal cell extracts and is phosphorylated on Ser-133 after dopamine stimulation in a D1 dopamine receptor-dependent manner.
CRE-binding protein Binding (binds) of associated with dopamine and dopamine receptor
2) Confidence 0.05 Published 1995 Journal Neuron Section Abstract Doc Link 7718243 Disease Relevance 0 Pain Relevance 0.31

General Comments

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