INT5186

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Context Info
Confidence 0.45
First Reported 1989
Last Reported 2010
Negated 3
Speculated 5
Reported most in Abstract
Documents 11
Total Number 16
Disease Relevance 8.78
Pain Relevance 5.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
spinal 2
astrocytes 2
macrophage 1
cerebrospinal fluid 1
peritoneal macrophages 1
Ifng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 37 100.00 Very High Very High Very High
Angina 12 100.00 Very High Very High Very High
intrathecal 7 100.00 Very High Very High Very High
rheumatoid arthritis 2 99.84 Very High Very High Very High
Dorsal horn 1 99.84 Very High Very High Very High
antidepressant 11 99.82 Very High Very High Very High
Pain 10 99.74 Very High Very High Very High
depression 6 97.64 Very High Very High Very High
Neuritis 7 97.04 Very High Very High Very High
spinal inflammation 4 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Necrosis 20 100.00 Very High Very High Very High
Cancer 20 100.00 Very High Very High Very High
Cv General 3 Under Development 12 100.00 Very High Very High Very High
Rheumatoid Arthritis 3 99.84 Very High Very High Very High
Nociception 4 99.36 Very High Very High Very High
Viral Meningitis 4 99.16 Very High Very High Very High
Systemic Sclerosis 4 97.80 Very High Very High Very High
Depression 6 97.64 Very High Very High Very High
Experimental Autoimmune Neuritis 7 97.04 Very High Very High Very High
Low Back Pain 6 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of intrathecal (i.t.) injection of the cytokine interferon-gamma) (IFN-gamma) on the spinal nociceptive flexor reflex was examined in decerebrate, spinalized, unanesthetized rats.
Spec (examined) Regulation (effect) of IFN-gamma in spinal associated with nociception, cytokine and intrathecal
1) Confidence 0.45 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7715823 Disease Relevance 0.17 Pain Relevance 0.17
The present study examined the effects of repeated intrathecal administration of interferon-gamma on dorsal horn neuronal responses under in vivo conditions.
Spec (examined) Regulation (effects) of interferon-gamma in neuronal associated with dorsal horn and intrathecal
2) Confidence 0.45 Published 2005 Journal Neuroscience Section Abstract Doc Link 16125859 Disease Relevance 0.46 Pain Relevance 0.71
Double blind controlled phase III multicenter clinical trial with interferon gamma in rheumatoid arthritis.
Regulation (controlled) of interferon gamma associated with pain and rheumatoid arthritis
3) Confidence 0.43 Published 1992 Journal Rheumatol. Int. Section Title Doc Link 1290019 Disease Relevance 0.34 Pain Relevance 0.37
The effect of intrathecal (i.t.) injection of the cytokine interferon-gamma) (IFN-gamma) on the spinal nociceptive flexor reflex was examined in decerebrate, spinalized, unanesthetized rats.
Spec (examined) Regulation (effect) of interferon-gamma in spinal associated with nociception, cytokine and intrathecal
4) Confidence 0.39 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7715823 Disease Relevance 0.17 Pain Relevance 0.17
This study examined the modulation of IFN-gamma induced MHC class I and II expression on normal Lewis rats and rats with EAN peritoneal macrophages cultured in the absence or presence of 10(-4)-10(-8) M of the 5-HT reuptake inhibiting antidepressants zimeldine, and its metabolites norzimeldine and cpp200 oxalate as well as the antidepressants clomipramine and imipramine, in addition amitriptyline, nortriptyline and maprotiline in EAN rats.
Spec (examined) Regulation (modulation) of IFN-gamma in peritoneal macrophages associated with nortriptyline, antidepressant, endep and neuritis
5) Confidence 0.39 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.33 Pain Relevance 0.61
Discs with annular disruption and concordant pain reproduction at a visual analog scale of 7 to 10/10 had greater IFN-gamma immunoreactivity than those without this finding (p=.003); however, at least some IFN-gamma immunoreactivity was found in all but one disc in the symptomatic group.
Regulation (immunoreactivity) of IFN-gamma
6) Confidence 0.25 Published 2010 Journal Spine J Section Body Doc Link 20207331 Disease Relevance 0 Pain Relevance 0
Astrocytes have previously been shown to respond to cytokines such as interleukin-1 beta, tumor necrosis factor-alpha, and gamma-interferon from multiple sources including microglia and astrocytes.
Regulation (respond) of gamma-interferon in astrocytes associated with necrosis, cancer and cytokine
7) Confidence 0.20 Published 1992 Journal Endocrinology Section Abstract Doc Link 1396335 Disease Relevance 0.30 Pain Relevance 0.22
Tumor necrosis factor-alpha treatment was unable to reverse the inhibitory effect of gamma-interferon pretreatment on proenkephalin messenger RNA levels in the astrocytes.
Regulation (effect) of gamma-interferon in astrocytes associated with necrosis and cancer
8) Confidence 0.20 Published 1992 Journal Endocrinology Section Abstract Doc Link 1396335 Disease Relevance 0.93 Pain Relevance 0.30
Finally, SNC 80 did not affect interferon-gamma- or lipopolysaccharide (LPS)-induced splenic nitric oxide, and LPS-induced tumor necrosis factor-alpha production by splenic macrophages.
Neg (not) Regulation (affect) of interferon-gamma in splenic macrophages associated with necrosis and cancer
9) Confidence 0.15 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9694952 Disease Relevance 0.28 Pain Relevance 0.25
There were no differences in corticosterone, IFN-gamma and IL-4 levels.
Neg (no) Regulation (differences) of IFN-gamma
10) Confidence 0.09 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link 20615224 Disease Relevance 0.78 Pain Relevance 0.20
Astrocytes have previously been shown to respond to cytokines such as interleukin-1 beta, tumor necrosis factor-alpha, and gamma-interferon from multiple sources including microglia and astrocytes.
Regulation (respond) of gamma-interferon in microglia associated with necrosis, cancer and cytokine
11) Confidence 0.07 Published 1992 Journal Endocrinology Section Abstract Doc Link 1396335 Disease Relevance 0.30 Pain Relevance 0.22
There were no significant differences in the antidepressant-induced changes in IFN-gamma or IL-10 between younger and older healthy volunteers and TRD patients.
Neg (no) Regulation (changes) of IFN-gamma associated with antidepressant and depression
12) Confidence 0.05 Published 2001 Journal J Clin Psychopharmacol Section Abstract Doc Link 11270917 Disease Relevance 0.24 Pain Relevance 0.82
To explore whether the production of the potent monocyte activator IFN-gamma is altered in UA, we compared cytokine production by T lymphocytes in patients with UA (Braunwald's class IIIB) and with stable angina (SA).
Spec (whether) Regulation (altered) of IFN-gamma in T lymphocytes associated with angina and cytokine
13) Confidence 0.05 Published 1999 Journal Circulation Section Abstract Doc Link 10571971 Disease Relevance 0.55 Pain Relevance 0.60
The maximal IFN-gamma response was observed in HLA-B27+/HLA-DQw3+ patients.
Regulation (response) of IFN-gamma
14) Confidence 0.02 Published 1989 Journal Rheumatol. Int. Section Abstract Doc Link 2510239 Disease Relevance 0.67 Pain Relevance 0.41
In both cases, the concentrations of IFN-gamma and IL-6 in cerebrospinal fluid (CSF) were increased.
Regulation (concentrations) of IFN-gamma in cerebrospinal fluid
15) Confidence 0.02 Published 2008 Journal Mod Rheumatol Section Abstract Doc Link 18283524 Disease Relevance 0.88 Pain Relevance 0.30
Analysis of patients' sera revealed significantly elevated concentrations of tumor necrosis factor alpha, interferon-gamma (IFN-gamma), granulocyte macrophage-colony stimulating factor (GM-CSF), and interleukin (IL)-1beta in ACS (vs.
Regulation (concentrations) of interferon-gamma in macrophage associated with acute coronary syndrome, necrosis and cancer
16) Confidence 0.01 Published 2004 Journal J. Leukoc. Biol. Section Abstract Doc Link 14742636 Disease Relevance 2.36 Pain Relevance 0.56

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